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Liver Kidney Microsomal (LKM) Antibody, IFA

Liver Kidney Microsomal (LKM) Antibody, IFA near me in Pune

Also referred as
Antibodies to liver and kidney microsomes
Anti-LKM
LKM
For men & women
Earliest reports in
216 hours
Contains
1 test
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The Liver Kidney Microsomal (LKM) Antibody, IFA test is a blood test used to detect the presence of antibodies directed against liver and kidney microsomal antigens (produced in various liver conditions). This test helps diagnose autoimmune liver diseases, particularly type 2 autoimmune hepatitis (AIH-2), distinguishing it from other liver conditions such as type 1 autoimmune hepatitis (AIH-1), viral hepatitis, drug-induced liver injury, and other liver disorders. This test is widely available with Tata 1mg labs in Pune at an affordable price.

The test can be done if symptoms of liver disease such as jaundice (yellowing of the skin and eyes), unexplained fatigue, abdominal pain, dark urine, pale stools etc, and abnormal liver function tests (particularly alanine aminotransferase (ALT), and aspartate aminotransferase (AST)) are noticed. This test can also be used to monitor the progression of type 2 AIH and the response to treatment.

 

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Understanding Liver Kidney Microsomal (LKM) Antibody, IFA

Autoimmune hepatitis (AIH) is a chronic liver disease in which the body's immune system mistakenly attacks the liver, causing inflammation and damage. There are two main types of AIH: Type 1, which is the most common and can affect people of any age, and Type 2, which primarily affects children and young adults with a higher occurrence in females. LKM-1 antibodies are autoantibodies that target specific liver and kidney cell structures. These antibodies are particular for autoimmune hepatitis type 2 (AIH-2), and their presence in the blood is a specific marker for AIH-2.

The Liver Kidney Microsomal (LKM) Antibody, IFA test is recommended if symptoms of liver disease such as jaundice (yellowing of the skin and eyes), unexplained fatigue, abdominal pain, dark urine, pale stools, and abnormal liver function tests (particularly alanine aminotransferase (ALT), and aspartate aminotransferase (AST)) are noticed. This test can also be used to monitor the progression of type 2 AIH and the response to treatment.

Apart from type 2 AIH, LKM-1 antibodies can also be found in other liver diseases, such as viral hepatitis and drug-induced hepatitis. Hence, the Liver Kidney Microsomal (LKM) Antibody, IFA test results should be interpreted in conjunction with other tests and clinical findings, such as a smooth muscle antibody (SMA) test, an antinuclear antibodies (ANA) test, or liver biopsies to make a definitive diagnosis. 

No special preparation is needed for this test. However, it is important to inform your doctor about all the medicines and supplements you take, as some of them may affect the test results and may need to be adjusted or temporarily discontinued before the test. 

Test result ranges may vary across laboratories. Abnormal test results require an expert interpretation; therefore, never try to self-medicate at home based solely on these results, and always consult a doctor for a proper understanding of the test results. The insights from this test help the doctor tailor an appropriate treatment plan.

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What does Liver Kidney Microsomal (LKM) Antibody, IFA measure?

The Liver Kidney Microsomal (LKM) Antibody, IFA test detects the presence of specific antibodies called liver kidney microsome-1 (LKM-1) antibodies. LKM-1 antibodies are specialized proteins produced by the body’s immune system that mistakenly target and attack a liver enzyme called cytochrome P450 2D6 (CYP2D6). These antibodies are strongly linked with type 2 autoimmune hepatitis (AIH), making it a highly specific marker for the disease. Type 2 AIH primarily affects children and young adults, unlike type 1 AIH, which is more common in adults. It can lead to inflammation and damage to liver cells, potentially progressing to cirrhosis if untreated. Additionally, determining the presence of LMK-1 antibodies over time can help assess the effectiveness of treatment and adjust therapeutic strategies if needed. The Liver Kidney Microsomal (LKM) Antibody, IFA test thus plays a crucial role in the management of AIH-2, guiding both the initial diagnosis and ongoing treatment decisions.

FAQs related to Liver Kidney Microsomal (LKM) Antibody, IFA in Pune

The Liver Kidney Microsomal (LKM) Antibody, IFA test is important because it helps diagnose type 2 autoimmune hepatitis (AIH), a condition where the immune system mistakenly attacks the liver cells.
This test is done when you have symptoms suggestive of liver disease, such as fatigue, jaundice, abdominal pain, unexplained weight loss, and abnormal findings on routine liver tests. This test is also done to distinguish type 2 autoimmune hepatitis from other autoimmune liver diseases.
The frequency of this test depends on your health condition and your doctor's recommendation. If you have been diagnosed with an autoimmune liver disease, regular testing may be advised to monitor your condition and the effectiveness of your treatment.
LKM-1 antibodies are specific to type 2 autoimmune hepatitis, whereas Autoimmune Hepatitis type 1 is associated with ANA (antinuclear antibodies) and SMA (smooth muscle antibodies).
The LKM-1 antibody test specifically identifies the presence of antibodies associated with autoimmune hepatitis type 2 but does not differentiate between acute and chronic conditions. Additional tests are required to assess liver function and damage.
Yes. In Pune, you can schedule the Liver Kidney Microsomal (LKM) Antibody, IFA test near you with Tata 1mg Labs. The test is easy to book, cost-effective, and available with a comprehensive report.
Yes, home sample collection for the Liver Kidney Microsomal (LKM) Antibody, IFA test is readily available in Pune. Tata 1mg Labs allows you to choose a date and time that suits your schedule for sample collection.
If you want to schedule the Liver Kidney Microsomal (LKM) Antibody, IFA test with Tata 1mg Labs in Pune, the procedure is fairly easy and hassle-free. Follow these steps to book a test: 1). Visit the Lab Tests section on the Tata 1mg website. 2). Add the test you want in the cart. 3). Pick a time and date slot according to your convenience; however, do consider the necessary prerequisites while scheduling a test. 4). You will receive a notification with all the details once the test is scheduled.
Tata 1mg Labs allows you to book tests at an affordable price in Pune. The Liver Kidney Microsomal (LKM) Antibody, IFA test can be booked at a pocket-friendly budget of Rs. 2029.
At Tata 1mg Labs, we understand the importance of timely results. We strive to provide fast turnaround times for test results, allowing you to get the information you need promptly. On average, we take 216 hours to provide the reports of the Liver Kidney Microsomal (LKM) Antibody, IFA test in Pune.
Content created by
Written by:
Dr. Lipika Khurana
BDS, PGDHHM
Reviewed by:
Dr. Swati Gupta (Anand)
MBBS, MD Lab Medicine
Want to know moreRead our editorial policy
Last Updated7th Oct 2025

Liver Kidney Microsomal (LKM) Antibody, IFA test price for other cities

Price inBangaloreRs. 1889
Price inNew DelhiRs. 1439
Price inMumbaiRs. 1879
Price inGurgaonRs. 1439
Price inGhaziabadRs. 1520

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Liver Kidney Microsomal (LKM) Antibody, IFA