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Dr. Shreya Gupta
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LH FSH Ratio

You need to provide
Blood
This test is for
Male, Female
Test Preparation
  1. In females, the preferred sampling time is day 2 or 3 of the menstrual cycle.
  2. Please provide the last day of your menstrual cycle at the time of sample collection.

Understanding LH FSH Ratio


What is LH FSH Ratio?

An LH FSH Ratio test measures and compares the level of follicle stimulating hormone and luteinizing hormone in your blood. These hormones are vital for sexual development and reproductive health. The LH FSH Ratio helps detect and monitor hormonal imbalance, fertility issues and early or delayed puberty. 

Follicle-stimulating hormone (FSH) and luteinizing hormones (LH) are two important hormones produced by the pituitary gland that work together to control sexual development and reproductive function. In women, FSH and LH control the menstrual cycles and enhance the formation and development of eggs for ovulation. In men, FSH and LH stimulate the production of testosterone which is necessary for the production of sperm. Thus, LH plays a major role in puberty and fertility in men too.

A doctor may recommend an LH FSH Ratio when a woman is experiencing symptoms of irregular or heavy menstrual periods, polycystic ovarian syndrome (PCOS), if she is facing difficulty in getting pregnant, and/or if pituitary or hypothalamus (an important part of the brain) problems are suspected. In men, this test can be performed when fertility issues and signs of low testosterone levels, such as decreased sex drive and low muscle mass, are observed. You may also be advised to undergo an LH FSH Ratio if you experience any symptoms of pituitary disorders. 

In women, the LH FSH Ratio is advised on the second or third day of the menstrual cycle. For men, the test can be done at any time. Your doctor may ask you to temporarily stop taking certain medications, such as birth control pills. Different methodologies may yield slightly different results depending on laboratory guidelines. Talk to your doctor about your specific test results. The results will help them evaluate your medical condition; make recommendations for diet, exercise, or medication; and formulate an overall treatment plan if needed.

What is LH FSH Ratio used for?

An LH FSH Ratio test is done to: 

  • Evaluate the function of reproductive organs (ovaries or testicles).

  • Assess menstrual irregularities and conditions such as amenorrhea or oligomenorrhea.

  • Detects disorders of the pituitary gland or diseases involving the ovaries.

  • Evaluate infertility issues in men and women.

  • Evaluate low sperm count in men.

  • Assess hypogonadism or gonadal failure in men.

  • Assess testicular dysfunction in men.

  • Evaluate early or delayed sexual maturation (puberty) in children.

What does LH FSH Ratio measure?

An LH FSH Ratio test helps assess the reproductive health in men and women by comparing the levels of FSH and LH in your blood. The production of FSH and LH is controlled by a feedback mechanism involving gonadotropin-releasing hormone situated in the hypothalamus in the brain. The gonadotropin-releasing hormone (GnRH), stimulates your pituitary gland to release follicle-stimulating hormone (FSH) as well as luteinizing hormone (LH). The released FSH and LH are transported to the reproductive organs through your blood where they bind to receptors in the testes or ovaries in males and females respectively. This is how FSH, along with LH, controls the reproductive function in both men and women. 

Answers to Patient Concerns & Frequently Asked Questions (FAQs) about LH FSH Ratio


Frequently Asked Questions about LH FSH Ratio

Q. Why do I need an LH FSH Ratio test?

You may need an LH FSH Ratio test to evaluate fertility issues such as low sperm count in males, assess menstrual problems in females, detect disorders of the pituitary gland, or other diseases related to the reproductive function in both women and men.

Q. Is an LH FSH Ratio test done at a particular time during the menstrual cycle?

For women, it is often recommended to perform an LH FSH Ratio test on day 2nd or 3rd of the menstrual cycle.

Q. Is there any risk associated with an LH FSH Ratio test?

No, there is no risk associated with an LH FSH Ratio test. However, some individuals may feel a slight sting when a needle is pricked and experience some normal bleeding that is usually not bothersome.

Q. What factors can affect an LH FSH Ratio test result?

Factors such as stress, medications, underlying medical conditions, and the menstrual cycle can affect the result of an LH FSH Ratio test.

Q. What can cause infertility in females?

The primary cause of infertility in females is failure to ovulate. This problem can occur due to polycystic ovarian disorder (PCOD) and primary ovarian insufficiency. Nearly 10% of women deal with infertility of some kind, and the chances of being infertile increases as a woman ages.

Q. What causes infertility in males?

Male infertility can be caused by various biological factors and environmental factors such as the inability to produce sperm or poor quality sperm, medical issues such as varicocele, ejaculation problems, undescended testicles, hormonal imbalances, and unhealthy habits including alcohol, smoking, and drugs.
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References

  1. Follicle-Stimulating Hormone [Internet]. Rochester, NY: University of Rochester Medical Center; [Accessed 14 Jan. 2024]. Available from: https://www.urmc.rochester.edu/encyclopedia/content.aspx?contenttypeid=167&contentid=follicle_stimulating_hormone External Link
  2. Follicle stimulating hormone [Internet]. Healthdirect; [Accessed 14 Jan. 2024]. Available from: https://www.healthdirect.gov.au/follicle-stimulating-hormone#:~:text=Follicle%20stimulating%20hormone%20(FSH)%20is,of%20eggs%20by%20the%20ovaries. External Link
  3. Orlowski M, Sarao MS. Physiology, Follicle Stimulating Hormone [Internet]. Treasure Island, Florida: StatPearls Publishing; 2023 Jan. Available from: https://www.ncbi.nlm.nih.gov/books/NBK535442/ External Link
  4. O'Herlihy C, Pepperell RJ, Evans JH. The significance of FSH elevation in young women with disorders of ovulation. Br Med J. 1980 Nov 29;281(6253):1447-50. [Accessed 14 Jan. 2024]. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1714809/ External Link
  5. Simoni M, Weinbauer GF, Gromoll J, Nieschlag E. Role of FSH in male gonadal function. Ann Endocrinol (Paris). 1999 Jul;60(2):102-6. [Accessed 14 Jan. 2024]. Available from: https://pubmed.ncbi.nlm.nih.gov/10456180/#:~:text=In%20the%20male%20FSH%20is,maintenance%20of%20normal%20sperm%20production External Link
  6. Fortin J, Boehm U, Deng CX, Treier M, Bernard DJ. Follicle-stimulating hormone synthesis and fertility depend on SMAD4 and FOXL2. FASEB J. 2014 Aug;28(8):3396-410. [Accessed 14 Jan. 2024]. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4101660/ External Link
  7. Arslan AA, Zeleniuch-Jacquotte A, Lukanova A, Rinaldi S, Kaaks R, Toniolo P. Reliability of follicle-stimulating hormone measurements in serum. Reprod Biol Endocrinol. 2003 Jun 18;1:49. [Accessed 14 Jan. 2024]. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC165593/#:~:text=FSH%20levels%20peak%20during%20the,result%20of%20ovarian%20function%20cessation. External Link
  8. Behre HM. Clinical Use of FSH in Male Infertility. Front Endocrinol (Lausanne). 2019 May 24;10:322. [Accessed 14 Jan. 2024]. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6543808/#:~:text=In%20male%20infertility%2C%20the%20indication,with%20hypogonadotropic%20hypogonadism%20(1). External Link
  9. Luteinizing Hormone [Internet]. Rochester, NY: University of Rochester Medical Center; [Accessed 14 Jan. 2024]. Available from: https://www.urmc.rochester.edu/encyclopedia/content.aspx?ContentTypeID=167&ContentID=luteinizing_hormone_blood External Link
  10. Kazmi SRH, Can AS. Luteinizing Hormone Deficiency. [Updated 2023 Sep 4]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK562219/ External Link
  11. Nedresky D, Singh G. Physiology, Luteinizing Hormone. [Updated 2022 Sep 26]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK539692/ External Link
  12. Reed BG, Carr BR. The Normal Menstrual Cycle and the Control of Ovulation. [Updated 2018 Aug 5]. In: Feingold KR, Anawalt B, Blackman MR, et al., editors. Endotext [Internet]. South Dartmouth (MA): MDText.com, Inc.; 2000-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK279054/ External Link

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