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HLA B-27, Flowcytometry

HLA B-27, Flowcytometry

Also referred as
Human leukocyte A antigen
Histocompatibility leukocyte A antigen
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An HLA B-27, Flowcytometry is a blood test that helps to identify the presence of Human Leukocyte Antigen B27(HLA B-27), a specific type of protein that is present on the surface of white blood cells (WBCs) that helps the body's immune system tell the difference between its own cells and foreign/harmful substances. This test can help diagnose autoimmune disorders associated with HLA B-27 antigen. 

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Understanding HLA B-27, Flowcytometry

Human leukocyte antigens (HLAs) are proteins that help the body's immune system tell the difference between its own cells and foreign invaders. They are made from instructions by inherited genes. Individuals with the HLA B-27 gene are more likely to develop autoimmune diseases such as ankylosing spondylitis, juvenile rheumatoid arthritis, rheumatoid arthritis type II, lupus erythematosus, Crohn's disease, etc. Your doctor may suggest an HLA B-27, Flowcytometry test if you experience signs and symptoms such as stiffness and chronic pain in the back, neck, or chest, inflammation in eyes, urethra, and joints, the appearance of skin lesions, recurring fever, abdominal pain, or digestive problems indicative of an autoimmune disorder. 

An HLA B-27, Flowcytometry test is also used during an organ transplant to match donated tissue with a person's tissue who is getting a transplant to minimize the risk of organ rejection and improve the success of the transplant. 

HLA B-27 gene detection can be done by two methods - flow cytometry and Polymerase chain reaction (PCR). An HLA B-27, Flowcytometry test identifies the expression of the HLA B-27 gene on WBC surfaces whereas the PCR method directly identifies the HLA B-27 gene within the genetic material. Both these tests help diagnose autoimmune diseases but the choice between these methods often depends on the clinical context and the specific disease being investigated. 

No special preparation is required for an HLA B-27, Flowcytometry test. Lab test results may vary across different laboratories. Abnormal test results require an expert interpretation, therefore, never try to self-medicate at home based solely on these results, and always consult a doctor for proper understanding of the test results. Discuss your symptoms and medical history to help the doctor correlate your clinical and laboratory findings.

Please note: This is an outsourced test. The sample for this test is collected by TATA 1MG and processed at a NABL accredited partnered lab.

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What does HLA B-27, Flowcytometry measure?

An HLA B-27, Flowcytometry test evaluates the presence or absence of HLA B27 antigen to rule out the possibility of any autoimmune disorder. Once recognizing any cell as foreign and dangerous, the human leukocyte antigens (HLA) set out to destroy those cells to protect the body from any harm. The majority of the HLAs protect the body from damage, however, HLA-B27 is a specific type of protein that contributes to the dysfunction of the body’s immune system. The presence of HLA-B27 on the white blood cells can cause the immune system to attack those otherwise healthy cells. When this occurs, it can result in an autoimmune disease.

FAQs related to HLA B-27, Flowcytometry

An HLA B-27, Flowcytometry test is performed when you experience symptoms such as joint pain, inflammation or stiffness suggestive of an autoimmune condition, if there is a family history of diseases associated with HLA B-27 antigen or to monitor the presence or absence of this genetic marker to track disease progression.
No, an HLA B-27, Flowcytometry test is usually considered safe and does not pose a significant risk. It is a simple blood test that involves needle pricking into a vein to withdraw a blood sample. However, as with any blood test there might be minor risks such as swelling or bruising at the site of needle prick which are usually self-limiting. If it is bothersome, consult your doctor.
Depending on your symptoms and medical history, your doctor may suggest other tests such as rheumatoid factor (RF), anti-cyclic citrullinated peptide (anti-CCP), erythrocyte sedimentation rate (ESR) or C-reactive protein (CRP) test.
Reactive arthritis, also called ‘Reiter’s syndrome’ is a form of inflammatory arthritis that develops in response to an infection which may be caused by certain bacteria such as Chlamydia, Campylobacter, Shigella, Salmonella, or Yersinia. This condition typically affects joints, eyes or urinary tract.
Ankylosing spondylitis is a form of inflammatory arthritis that primarily affects the spine, but can affect other joints as well. Its possible complications are spinal fusion, breathing difficulties, heart problems, eye inflammation, bone fractures etc.
No, it is possible to have a positive HLA-B27 without any specific disease. Some individuals have the HLA-B27 protein but never develop an associated disorder.
Content created by
Written by:
Dr. Lipika Khurana
BDS, PGDHHM
Reviewed by:
Dr. Swati Gupta (Anand)
MBBS, MD Lab Medicine
Want to know moreRead our editorial policy
Last Updated13th Dec 2025

HLA B-27, Flowcytometry test price for other cities

Price inBangaloreRs. 2399
Price inMumbaiRs. 2749
Price inKolkataRs. 2159
Price inNew DelhiRs. 2159
Price inNoidaRs. 2280

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HLA B-27, Flowcytometry