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Hepatitis B (Core) Total Antibody

Also referred as

HBV Anti HbcAg total Core antigen Total

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The Hepatitis B (Core) Total Antibody blood test identifies total antibodies (IgM and IgG) against the hepatitis B core antigen (anti-HBc). It helps determine whether an individual has been exposed to the hepatitis B virus (HBV) in the past or if they are currently infected, offering crucial information about the history and stage of the infection.

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Understanding Hepatitis B (Core) Total Antibody

The Hepatitis B Core Antibody (anti-HBc) is a type of antibody produced by the immune system in response to infection with the hepatitis B virus (HBV). These antibodies specifically target the core antigen of the virus, which is a protein found inside the viral particle.

The Hepatitis B (Core) Total Antibody detects the presence of hepatitis B core antibodies (anti-HBc) in the blood, which are present in the blood after exposure to the virus. It is useful for determining whether an individual has ever been infected with HBV, whether the infection is active, or if the individual has cleared the virus from their system. This test is valuable for evaluating individuals with a history of liver disease as well as those at risk of HBV infection, such as healthcare workers or individuals with multiple sexual partners. Detecting the presence of anti-HBc antibodies helps doctors differentiate between different phases of HBV infection and guide treatment decisions. Early diagnosis and intervention can help prevent complications such as cirrhosis or liver cancer, which are associated with chronic HBV infection.

A positive result generally indicates that the individual has had an exposure to hepatitis B at some point in their life, but it does not indicate whether the infection is currently active or resolved. To further clarify the current status of the infection, additional tests like the Hepatitis B surface antigen (HBsAg) or Hepatitis B DNA (viral load) tests can be recommended.

No special preparation is needed for this test. Eating and drinking can be done as per the daily routine. However, inform the doctor about all the medications or supplements or underlying liver disease, as these factors may influence the test results.

Lab test results may vary across laboratories. Abnormal test results require an expert interpretation. Do not self-medicate. Always consult a doctor to understand the test results correctly.

What does Hepatitis B (Core) Total Antibody measure?

The Hepatitis B (Core) Total Antibody test identifies total antibodies (IgM and IgG) against the hepatitis B core antigen (anti-HBc). It is a key marker for determining whether an individual has ever been infected with the virus, regardless of whether the infection is currently active. By detecting the presence of anti-HBc, doctors can assess the progression of the infection and make informed decisions about treatment and monitoring. This test is crucial for understanding the history of hepatitis B in an individual, which can help prevent future liver damage and transmission of the virus.

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FAQs related to Hepatitis B (Core) Total Antibody

What is the Hepatitis B (Core) Total Antibody test?

The Hepatitis B (Core) Total Antibody blood test identifies total antibodies (IgM and IgG) against the hepatitis B core antigen (anti-HBc). It helps determine whether an individual has been exposed to the hepatitis B virus (HBV) in the past, whether they have an active infection, or if they have cleared the virus from their body.

Why is the Hepatitis B (Core) Total Antibody test important?

This test is important for determining whether someone has had a past infection with hepatitis B. It helps doctors assess the risk of chronic HBV infection, guide treatment decisions, and monitor patients who may have been exposed to the virus. It is also useful for identifying individuals who have cleared the virus from their system and those who may need further testing for liver damage.

What does a positive result for Hepatitis B (Core) Total Antibody mean?

A positive result indicates that you have been exposed to the hepatitis B virus at some point, either through an acute or chronic infection. It means your immune system has produced antibodies against the virus. However, a positive result does not specify whether the infection is currently active or if it has resolved. Additional tests may be needed to assess the status of the infection.

What does a negative result for Hepatitis B (Core) Total Antibody mean?

A negative result means that there are no detectable antibodies against the hepatitis B core antigen in your blood. This typically indicates that you have never been exposed to the hepatitis B virus, although it is important to note that it does not rule out exposure in the past or early-stage infections.

Can the Hepatitis B (Core) Total Antibody test detect if the infection is active?

No, the Hepatitis B (Core) Total Antibody test cannot differentiate between an active or resolved infection. While a positive result indicates past exposure to the virus, further tests, such as the Hepatitis B surface antigen (HBsAg) or Hepatitis B DNA tests, are needed to determine if the infection is still active and replicating.

Who should get tested for Hepatitis B (Core) Total Antibody?

The test is recommended for people who may have been exposed to hepatitis B, including a) Individuals with a history of unprotected sex or multiple sexual partners. b) Healthcare workers at risk of exposure to bloodborne pathogens. c) People with a history of intravenous drug use or needle sharing. d) People with liver disease or those undergoing regular liver monitoring. e) People born to mothers infected with hepatitis B. f) Those undergoing treatment for hepatitis B or liver disease.

Can this test help determine if I need to be vaccinated against hepatitis B?

The Hepatitis B (Core) Total Antibody test does not provide information about your immunity status. To assess whether you need a hepatitis B vaccination, your doctor may recommend a Hepatitis B surface antibody (anti-HBs) test. A positive anti-HBs test means you are immune, while a negative result suggests you may need the vaccine.

What happens if I test positive for Hepatitis B (Core) Total Antibody?

If you test positive, your doctor may recommend additional tests to assess the stage of the infection, whether it is active, and whether antiviral treatment is necessary. These tests could include the Hepatitis B surface antigen (HBsAg), Hepatitis B e antigen (HBeAg), and Hepatitis B viral load tests.

What precautions should be taken if diagnosed with Hepatitis B?

If you are diagnosed with Hepatitis B, it’s important to follow your doctor’s treatment plan. You should avoid alcohol, eat a healthy and balanced diet, and exercise regularly. Additionally, inform those close to you so they can get tested and vaccinated if necessary.

What precautions should be taken if diagnosed with Hepatitis B?

How does the hepatitis B core antibody differ from the surface antibody (anti-HBs)?

Unlike the hepatitis B surface antibody (anti-HBs), which indicates immunity against hepatitis B, the core antibody (anti-HBc) signifies that the body has been exposed to the virus. It does not necessarily imply immunity.

How does Tata 1mg ensure accurate lab test results?

Tata 1mg ensures accurate lab test results through certified laboratories that use advanced technology and adhere to stringent quality control measures. This commitment to high standards guarantees reliable results.

Content created by

Dr. Swati Gupta (Anand)

MBBS, MD Lab Medicine

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Last Updated

7th Oct 2025