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HE4 With ROMA Index

HE4 With ROMA Index near me in Hyderabad

Also referred as
HE4
Human Epididymis Protein 4 CA125
Cancer Antigen 125 ROMA
+2
Risk of Ovarian Malignancy Algorithm
ROMA Score
For women
Earliest reports in
144 hours
Contains
3 tests
Know more about this test

The HE4 With ROMA Index is a diagnostic test to assess the risk of epithelial ovarian cancer in women and is available with Tata 1mg in Hyderabad. This test combines the measurement of HE4 (Human epididymis protein 4), a protein produced by cells in the ovaries and the lining of the respiratory tract; CA-125 (cancer antigen-125), a tumor marker that is often elevated in women with ovarian cancer; and the Risk of Ovarian Malignancy Algorithm (ROMA) index along with other factors like the woman’s age and menopausal status for calculation of a numerical score. This combination of biomarkers provides valuable information for the early detection and management of ovarian cancer. 

The HE4 With ROMA Index test is available in Hyderabad at an affordable price with Tata 1mg labs. It is recommended for women who are above 18 years of age, have an adnexal mass for which surgery is planned, and have not yet been referred to a doctor who specializes in diagnosing and treating cancer (oncologist). 

No special preparation is required for this test. You can eat and drink as per your routine. However, providing a brief clinical history or doctor's prescription during sample collection is important. Additionally, indicate the date of your last menstrual period (LMP) or menopausal status.

Samples required
Blood
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Understanding HE4 With ROMA Index

Ovarian cancer is one of the most common gynecological cancers in women. Early detection of ovarian cancer can be challenging due to its non-specific symptoms often mistaken for other conditions. This highlights the importance of early detection and advanced diagnostic tests like the HE4 With ROMA Index test.

The HE4 With ROMA Index test is not intended as a screening or standalone diagnostic test. It should be used in combination with other diagnostic tools like imaging, biopsies, etc., as well as clinical evaluation for confirmatory diagnosis of ovarian cancer. This test combines the measurement of HE4, a protein that is produced by cells in the ovaries and the lining of the respiratory tract, often elevated in epithelial ovarian cancer, and CA 125, a protein that can be elevated in ovarian cancer and other physiological or pathological conditions such as menstruation, pregnancy, endometriosis, uterine fibroids, and pelvic inflammatory disease. 

The ROMA index is a mathematical formula that combines the levels of HE4 and CA 125 with menopausal status (defined as the absence of periods for 12 months in a row) to estimate ovarian cancer risk, categorizing women with an adnexal mass into high-risk or low-risk groups, and enhances accuracy in early detection. ROMA is not a definitive indicator of cancer presence or absence and is not intended for general cancer screening. However, a low-risk ROMA result should not rule out an oncologist (a doctor who specializes in diagnosing and treating cancer) referral if the initial cancer risk is high. Additionally, ROMA has not been validated for patients previously treated for cancer, undergoing chemotherapy, or below 18 years of age.

The HE4 With ROMA Index test is specifically recommended for women above 18 years of age having adnexal masses planned for surgery and who have not yet been referred to an oncologist. This test is not suitable for monitoring mucinous or germ-cell ovarian cancer. It offers a more nuanced assessment of ovarian cancer risk, particularly distinguishing between malignant (cancerous) and benign (non-cancerous) ovarian masses. 

No special preparation is required for this test. However, a brief clinical history or doctor's prescription should be provided during sample collection. Additionally, indicate the date of your last menstrual period (LMP) or menopausal status. Inform your doctor about any medications or supplements you may be taking, as these could impact the test results. 

Don't self-medicate at home solely based on the test results, and always consult a doctor for a proper understanding of your health needs.

Please note: This is an outsourced test. The sample for this test is collected by TATA 1MG and processed at a NABL accredited partnered lab.

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What does HE4 With ROMA Index measure?

Contains 3 tests

The HE4 With ROMA Index test measures key biomarkers to assess the risk of epithelial ovarian cancer. It includes Human Epididymis Protein 4 (HE4), CA 125, and the Risk of Ovarian Malignancy Algorithm (ROMA) index evaluation. In cases of ovarian cancer, the levels of HE4 and CA 125 are often elevated. The ROMA index combines HE4 levels with CA 125 along with other factors like the woman’s age and menopausal status for the calculation of a numerical score. This combination of biomarkers and clinical history enhances the accuracy of the HE4 With ROMA Index test in predicting the presence of epithelial ovarian cancer, particularly in its early stages. This test is instrumental in women with pelvic masses who have not yet undergone surgery.

What sets the HE4 With ROMA Index test apart is its ability to provide a nuanced assessment of epithelial ovarian cancer risk. While CA 125 alone can sometimes yield false positive results due to its elevation in other conditions like endometriosis, HE4 offers added specificity and precision. Moreover, the ROMA index considers factors like age and menopausal status, further refining the risk assessment. This comprehensive approach not only helps in the early detection of epithelial ovarian cancer but also helps differentiate between malignant (cancerous) and benign (non-cancerous) ovarian masses, guiding doctors in making informed decisions regarding further diagnostic workup and determining whether a woman with a pelvic mass is at high or low risk for ovarian cancer before surgery, which can guide treatment decisions and help in planning surgery. 

HE4 - Human Epididymis Protein 4
ROMA Value

CA125 is a protein found in most ovarian cancer cells and some normal tissues. A CA125 (Cancer Antigen 125) test is commonly advised to detect ovarian cancer by measuring the amount of CA125 protein in the blood. A deranged level of CA125 antigen may indicate the presence of certain cancers, primarily ovarian cancer or other non-cancerous conditions, including endometriosis, pelvic inflammatory disease, ovarian cysts, etc.

Know more about CA125 (Cancer Antigen 125)

FAQs related to HE4 With ROMA Index in Hyderabad

The HE4 With ROMA Index test is used to assess the risk of epithelial ovarian cancer in women. It measures the level of Human Epididymis Protein 4 (HE4) and CA 125 in combination with the Risk of Ovarian Malignancy Algorithm (ROMA) index. This test is valuable for early detection and management of ovarian cancer. Also, it helps monitoring ovarian cancer treatment and recurrence, as well as screening of high-risk individuals.
This test is recommended for women who have a pelvic mass or other symptoms suggestive of ovarian cancer, and for women with a family history or other risk factors for ovarian cancer.
A phlebotomist (a trained professional to perform blood draws) will clean your skin using an antiseptic alcohol cotton swab or wipe and take blood samples from your vein using a needle. The blood sample will be stored safely and transported to the laboratory for analysis.
Yes, the HE4 With ROMA Index test can be used to monitor response to treatment in women diagnosed with epithelial ovarian cancer.
Yes, you can book the HE4 With ROMA Index test in Hyderabad near you with Tata 1mg Labs. The test can be booked easily, is affordable, and comes with an easy-to-understand report.
Yes, home sample collection for the HE4 With ROMA Index test is readily available in Hyderabad. Tata 1mg Labs allows you to choose a date and time that suits your schedule for sample collection.
If you want to schedule the HE4 With ROMA Index test with Tata 1mg Labs in Hyderabad, the procedure is fairly easy and hassle-free. Follow these steps to book a test: 1). Visit the Lab Tests section on the Tata 1mg website. 2). Add the test you want in the cart. 3). Pick a time and date slot according to your convenience; however, do consider the necessary prerequisites while scheduling a test. 4). You will receive a notification with all the details once the test is scheduled.
Tata 1mg Labs is a pocket-friendly platform for booking lab tests in Hyderabad. The HE4 With ROMA Index test is available at an affordable price of Rs. 2299.
The e-report of your HE4 With ROMA Index test can be found on the Tata 1mg app in downloadable PDF form. This allows you to access your test results at convenience and securely share them with your healthcare provider for further consultation and guidance regarding your overall health. You can also opt for a hard copy of the reports at a minimal price.
At Tata 1mg Labs, we understand the importance of timely results. We strive to provide fast turnaround times for test results, allowing you to get the information you need promptly. On average, we take 144 hours to provide the reports of the HE4 With ROMA Index test in Hyderabad.
Content created by
Written by:
Dr. Lipika Khurana
PGDHHM, BDS
Reviewed by:
Dr. Swati Gupta (Anand)
MD Lab Medicine, MBBS
Want to know moreRead our editorial policy
Last Updated4th Nov 2025

HE4 With ROMA Index test price for other cities

Price inMumbaiRs. 2339
Price inNew DelhiRs. 2069
Price inGurgaonRs. 2069
Price inLucknowRs. 2190
Price inKolkataRs. 2069

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Who will collect your samples?
Tata 1mg certified phlebotomists
Contains 3 tests
HE4 - Human Epididymis Protein 4
ROMA Value
CA125 (Cancer Antigen 125)