
DPYD Mutation Analysis near me in Dombivli







The DPYD Mutation Analysis test detects genetic mutations in the DPYD gene, which provides instructions for making the Dihydropyrimidine Dehydrogenase (DPD) enzyme. This enzyme helps break down certain chemotherapy medicines like 5-fluorouracil (5-FU) and Capecitabine. The test helps identify individuals at risk of severe side effects from these medicines, allowing doctors to adjust doses or choose safer alternatives before treatment begins. Identifying DPD deficiency through targeted gene sequencing allows doctors to predict potential drug-related toxicity before treatment begins. Based on the test results, the doctor may adjust the chemotherapy dose, enhance monitoring, or choose an alternative drug, ensuring effective and safer cancer therapy. This test is widely available with Tata 1mg labs at an affordable price in Dombivli.








What does DPYD Mutation Analysis measure?
The DPYD Mutation Analysis test detects specific genetic mutations in the DPYD gene that produces the Dihydropyrimidine Dehydrogenase (DPD) enzyme. This enzyme is crucial for breaking down fluoropyrimidine-based chemotherapy medicines such as 5-Fluorouracil (5-FU) and Capecitabine in the liver. Mutations in the DPYD gene can lower or completely stop DPD enzyme activity, leading to drug accumulation in the body and causing severe or even life-threatening side effects. By identifying these mutations before treatment, doctors can predict how effectively a patient can metabolize these medicines, adjust chemotherapy doses, and reduce the risk of toxicity.





- Patil VM, Noronha V, Joshi A, Zanwar S, Ramaswamy A, Arya S, Mahajan A, Bhattacharjee A, Prabhash K. Dihydropyrimidine dehydrogenase mutation in neoadjuvant chemotherapy in head and neck cancers: Myth or reality? South Asian J Cancer. 2016 Oct-Dec;5(4):182-185.
- Cancer Research UK. DPD deficiency [Internet]. London: Cancer Research UK; updated 11 July 2023; [Accessed 04 Nov 2025]. Available from:
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