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Coagulation Profile (PT/INR & aPTT)

Also referred as

Clotting factor test

Coagulation profile

3,844+ booked recently

For men & women

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12 hours

Contains

2 tests

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A Coagulation Profile (PT/INR & aPTT), incorporating prothrombin time international normalized ratio (PT/INR) and activated Partial Thromboplastin Time (aPTT) test, is a comprehensive blood test that assesses the body's ability to form blood clots. This profile helps diagnose bleeding disorders, such as hemophilia, and monitor the effects of anticoagulant medications.

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Blood

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Preparations

Overnight fasting required for 8 to 12 hours

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Understanding Coagulation Profile (PT/INR & aPTT)

Clotting or coagulation factors are the proteins found in the blood that help stop bleeding when there is a wound or cut. A Coagulation Profile (PT/INR & aPTT) is used to assess the clotting function of the blood and determine if there is a problem with any of your clotting factors. Your doctor may suggest this test if you have symptoms of bleeding or clotting disorders, such as unexplained heavy bleeding, easy bruising, unusual heavy nose bleeds, leg swelling, redness on the legs, or chest pain. This test can also help check for clotting function before a scheduled surgery.

A Coagulation Profile (PT/INR & aPTT), including PT/INR and aPTT tests, is used to assess the risk of bleeding or clotting disorders, such as hemophilia, deep vein thrombosis, vitamin K deficiency, monitor anticoagulant therapy, and evaluate liver function. A PT/INR test helps measure how long it takes for blood to clot. The International Normalized Ratio (INR) is a standardized method used to interpret test results consistently. This test is used primarily to monitor the effectiveness of anticoagulant medications, such as warfarin, and assess liver function. The aPTT test especially helps evaluate the effectiveness of anticoagulant medications, such as heparin.

Usually, overnight fasting (8-12 hours) is preferred before a Coagulation Profile (PT/INR & aPTT), and a duly filled coagulation requisition form is mandatory for sample collection. If you take anticoagulant medication, giving the testing sample before the daily dose is taken is advised. Also, inform the doctor if you are taking medications such as blood thinners, as they may interfere with test results, and your doctor may adjust your dose or stop them temporarily before the test.

Test result ranges are approximate and may differ slightly between labs depending on the methodology and laboratory guidelines. Talk to your doctor about your specific test results. Narrate your complete medical and family history to help the doctor correlate your clinical and laboratory findings. The test results will help them prevent, manage, and treat coagulation-related health issues.

What does Coagulation Profile (PT/INR & aPTT) measure?

Contains 2 tests

A Coagulation Profile (PT/INR & aPTT) includes blood tests that provide information about the blood's clotting ability. This profile measures prothrombin time international normalized ratio (PT/INR) and activated partial thromboplastin time (aPTT).

The Prothrombin Time (PT) and aPTT tests measure how long the blood takes to clot. Precisely, they assess the factors in the blood that help initiate the clotting process. The INR is a standardized interpretation of the PT results. It is calculated to ensure consistency in interpreting PT values across different laboratories and testing methods. The INR is essential when monitoring patients on anticoagulant medications like warfarin. The INR helps adjust medication dosages to maintain blood clotting within a therapeutic range. The aPTT test is significant when monitoring patients on anticoagulant medications, such as heparin.

PT INR (Prothrombin Time with INR)

The PT INR (Prothrombin Time with INR) test measures the Prothrombin Time (PT) and reports it as the International Normalized Ratio (INR). The PT measures how long it takes for blood to clot. Specifically, it assesses the factors in the blood that help initiate the clotting process. The INR is a standardized interpretation of the PT results. It is calculated to ensure consistency in interpreting PT values across different laboratories and testing methods. It is particularly important when monitoring patients on anticoagulant medications, such as warfarin. The INR helps adjust medication dosages to maintain blood clotting within a therapeutic range.

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Activated Partial Thromboplastin Time

An Activated Partial Thromboplastin Time test measures the time taken by the blood to form a clot. In other words, it is a screening test that helps evaluate a person’s ability to form blood clots. The test analyzes the amount and the function of specific proteins in the blood called coagulation or clotting factors, which are an essential part of blood clot formation.

Blood clotting or coagulation occurs through a series of cascade reactions due to the activation of clotting factors. There are a total of thirteen clotting factors within our bodies that aid in clot formation, and for healthy clot formation, all clotting factors need to be in the right balance. Any imbalance of these factors can lead to a blood clotting disorder.

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FAQs related to Coagulation Profile (PT/INR & aPTT)

What is a Coagulation Profile (PT/INR & aPTT)?

A Coagulation Profile (PT/INR & aPTT) is a set of blood tests, including PT/INR and aPTT. It is a screening test that gives information about the clotting ability of the blood. This test helps the doctor assess the risk of excessive bleeding or clot formation (thrombosis) somewhere in the blood vessels.

What are the risks associated with a Coagulation Profile (PT/INR & aPTT)?

A Coagulation Profile (PT/INR & aPTT) usually possesses no risks. However, some people may feel a slight sting when a needle is pricked and experience some bleeding that is normal and usually not bothersome. Some people may rarely experience slight swelling or bruising at the site of the needle prick. Applying ice 3-4 times daily for about a week may help reduce swelling and bruising. If it does not get better, consult your doctor.

When should I take a Coagulation Profile (PT/INR & aPTT)?

You may need a Coagulation Profile (PT/INR & aPTT) if you have signs and symptoms of bleeding disorders, such as unexplained heavy bleeding, abnormal menstrual bleeding in women, easy bruising, excessive bleeding from cuts and wounds, frequent nosebleeds that won’t stop, bleeding gums, and repeated heart attacks or strokes.

What conditions can affect blood clotting to cause bleeding disorders?

Certain inherited conditions such as hemophilia, clotting factor deficiency, vitamin K deficiency, liver diseases, bone marrow disorders, von Willebrand disease, and cancers like leukemia can cause bleeding disorders.

What other tests can be advised by the doctor in case of abnormal results of a Coagulation Profile (PT/INR & aPTT)?

In case of abnormal results of a Coagulation Profile (PT/INR & aPTT), the doctor can advise platelet count test, thrombin time test, fibrinogen testing, coagulation factor tests, lupus anticoagulant testing, and test for von Willebrand factor.

What should I do if my bleeding does not stop?

Apply direct pressure on the cut or wound with a clean cloth, tissue, or gauze until the bleeding stops. If blood soaks through, add another fabric or bandage and continue putting pressure on the cut. Seek medical help if the bleeding won’t stop.

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Last Updated

13th Oct 2025