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The CLPD Advance measures multiple cell surface markers (antigens) on white blood cells to detect abnormal patterns in lymphocyte populations. It uses Flow Cytometry, a technique that evaluates the physical and chemical characteristics of cells in a fluid as they pass through lasers. This allows the test to determine the type of cells, their number, size, shape, and the presence of specific surface markers.
In the context of CLPD, Flow Cytometry helps identify whether the disorder involves B-cells, T-cells, or other lymphocyte types, and analyzes markers such as CD5, CD10, CD19, CD20, CD23, CD38, FM7, Kappa, Lambda, CD100, among others. These markers provide important information for classifying the type of lymphoproliferative disorder, assessing its aggressiveness, and differentiating between various forms of leukemia. By combining cell counts, physical characteristics, and marker expression, this test enables doctors to diagnose the disorder accurately, monitor treatment response, and guide personalized therapy decisions.




