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CLL Prognostication/Risk Stratification Gene Panel

CLL Prognostication/Risk Stratification Gene Panel

Also referred as
Chronic Lymphocytic Leukaemia Genetic Testing
For men & women
Earliest reports in
432 hours
Contains
1 test
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The CLL Prognostication/Risk Stratification Gene Panel is an advanced genetic test that helps predict how Chronic Lymphocytic Leukemia (CLL) is likely to progress. It detects specific gene mutations linked to disease behavior, treatment response, and overall prognosis. This information helps doctors personalize treatment and make better-informed decisions for managing CLL.

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Understanding CLL Prognostication/Risk Stratification Gene Panel

The CLL Prognostication/Risk Stratification Gene Panel is a Next-Generation Sequencing (NGS)–based molecular test performed on EDTA whole blood samples. It analyzes key genes and mutations linked with the development and behavior of Chronic Lymphocytic Leukemia (CLL), a cancer of the blood and bone marrow that affects white blood cells.

CLL is a heterogeneous disease, meaning it behaves differently in every patient. Some cases progress slowly and require only monitoring, while others are more aggressive and need early intervention. This gene panel helps doctors assess an individual’s risk level and make informed clinical decisions.

The test evaluates mutations in important hotspot, full, and fusion genes associated with CLL and other hematological malignancies:

  • Hotspot genes: ABL1, FLT3, JAK2, MYD88, SF3B1
  • Full genes: SH2B3, TP53
  • Gene fusions: FGFR1, FGFR2, PDGFRA, PDGFRB

By detecting these gene mutations, the test helps doctors stratify patients into risk categories (low, intermediate, or high risk) and decide on the most suitable treatment approach, whether active monitoring, targeted therapy, or clinical trial enrollment.

Doctors may recommend this test for individuals with newly diagnosed CLL, persistent or relapsed disease, or those who show clinical signs of disease progression such as rapid lymphocyte doubling, cytopenias, or organ enlargement.

For this test, it is important to submit the clinical history, previous test results, and a doctor’s prescription at the time of sample collection. The Tata 1mg consolidated Test Requisition Form (TRF) must also be duly filled.

Lab test results may vary across different laboratories. Abnormal test results require an expert interpretation. Therefore, never try to self-medicate at home based solely on these results, and always consult a doctor for a proper understanding of the test results.

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What does CLL Prognostication/Risk Stratification Gene Panel measure?

The CLL Prognostication/Risk Stratification Gene Panel analyzes multiple genes in the blood that are linked to the development and progression of Chronic Lymphocytic Leukemia (CLL). It uses advanced PCR-based next-generation sequencing (NGS) to detect genetic mutations and variations that help predict how aggressive the disease might be and how it may respond to treatment.

This panel includes:

Hotspot genes (ABL1, FLT3, JAK2, MYD88, SF3B1): Common regions where mutations often occur in blood cancers.

Full genes (SH2B3, TP53): Entire genes analyzed to identify both common and rare mutations that influence prognosis and therapy response.

Gene fusions (FGFR1, FGFR2, PDGFRA, PDGFRB): Abnormal joining of genes that may drive cancer growth and affect targeted treatment choices.

By studying these genes, the test helps determine disease prognosis, identify high-risk patients, and guide doctors in planning personalized treatment strategies and follow-up care.

FAQs related to CLL Prognostication/Risk Stratification Gene Panel

It is a genetic test that uses Next-Generation Sequencing (NGS) to detect mutations and fusions in multiple genes associated with Chronic Lymphocytic Leukemia (CLL). The results help predict disease progression and guide personalized treatment.
CLL behaves differently in each patient. This test helps doctors understand the genetic profile of the disease, assess risk levels, and make evidence-based treatment decisions to improve long-term outcomes.
This test is recommended for individuals who: Have been newly diagnosed with CLL Show signs of disease progression or relapse Have unexplained low blood counts (cytopenias) or rapidly rising lymphocyte counts Need risk assessment before starting or changing therapy
A phlebotomist will clean your skin using an antiseptic alcohol cotton swab or wipe and take blood samples from your vein using a needle. The blood sample will be stored safely and transported to the laboratory for analysis.
No fasting is required for this test. You can schedule it at your convenience without avoiding food or water beforehand.
No, the CLL Prognostication/Risk Stratification Gene Panel is generally safe with minimal risks. However, you may feel slight discomfort during blood sample collection, but the chances of serious complications are extremely rare.
Abnormal findings may indicate the presence of high-risk genetic mutations, suggesting that the CLL could progress faster or respond differently to treatment. Your doctor will interpret the results and plan a personalized treatment approach accordingly.
No, this panel is designed specifically for CLL-related mutations and does not detect other cancers.
Yes. Your doctor may recommend retesting if your disease relapses or before adjusting treatment plans.
Yes. Since CLL primarily affects older individuals, this test is safe and commonly used for elderly patients.
Chronic Lymphocytic Leukemia (CLL) is a type of blood and bone marrow cancer that affects white blood cells called lymphocytes. These abnormal cells build up slowly over time, interfering with normal blood cell production and immune function.
Content created by
Written by:
Shweta Prakash
MSc, BSc
Reviewed by:
Dr. Swati Gupta (Anand)
MD Lab Medicine, MBBS
Want to know moreRead our editorial policy
Last Updated4th Mar 2026

CLL Prognostication/Risk Stratification Gene Panel test price for other cities

Price inHyderabadRs. 19950
Price inAllahabadRs. 19950
Price inGhaziabadRs. 19950
Price inBangaloreRs. 19950
Price inBhopalRs. 19950

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Contains 1 test
CLL Prognostication/Risk Stratification Gene Panel