Autoimmune Liver Diseases IgG Profile, LIA
Understanding Autoimmune Liver Diseases IgG Profile, LIA
What is Autoimmune Liver Diseases IgG Profile, LIA?
The Autoimmune Liver Diseases IgG Profile, LIA is a group of blood tests that helps detect several key markers associated with autoimmune liver conditions such as autoimmune hepatitis (AIH), primary biliary cholangitis (PBC), and primary sclerosing cholangitis (PSC). These conditions occur when the immune system mistakenly attacks healthy liver cells (producing autoantibodies), leading to inflammation and potential liver damage.
The Autoimmune Liver Diseases IgG Profile, LIA checks for specific IgG autoantibodies (proteins) linked to autoimmune liver diseases. This profile helps find out if someone has conditions like autoimmune hepatitis (AIH) or primary biliary cholangitis (PBC). It can also help distinguish between liver conditions so that the right treatment can be initiated. It can also help distinguish between different liver conditions and rule out other problems with similar symptoms such as viral hepatitis, fatty liver disease, or drug-induced liver injury.
The profile helps detect the presence of IgG antibodies against antigens such as AMA M2, Sp100, LKM1, gp210, LC1 and SLA, using the line immunoassay (LIA) technique. Early detection and treatment are important to manage these conditions and prevent serious liver damage such as cirrhosis and liver failure.
Doctors may recommend this profile if there are symptoms such as ongoing fatigue, yellowing of the skin or eyes (jaundice), itching, abdominal discomfort, or abnormal liver function test results. The profile is also done to assess the effectiveness of the treatment or the progression of the disease over time.
No special preparation is required for the Autoimmune Liver Diseases IgG Profile, LIA. It is important to inform the doctor about all the medicines and supplements being taken, as these may affect the test results potentially requiring dosage adjustments or temporary discontinuation before the test.
Test result ranges may vary across laboratories. Abnormal test results require an expert interpretation. Therefore, never try to self-medicate at home based solely on these results, and always consult a doctor for a proper understanding of the test results. The insights from this test help the doctor tailor an appropriate treatment plan.
What is Autoimmune Liver Diseases IgG Profile, LIA used for?
The Autoimmune Liver Diseases IgG Profile, LIA is done:
- To help find out if the symptoms are caused by autoimmune liver disease.
- To differentiate between types of autoimmune liver problems like AIH and PBC.
- To monitor disease severity and response to treatment.
- To help rule out other liver diseases with similar symptoms.
What does Autoimmune Liver Diseases IgG Profile, LIA measure?
Contains 6 testsThe Autoimmune Liver Diseases IgG Profile, LIA measures the presence of specific autoantibodies that attack components of the liver and associated cells, helping confirm a diagnosis of autoimmune liver disease. These antibodies include:
- AMA M2: Indicates the presence of antimitochondrial antibodies, which are specific for primary biliary cholangitis (PBC).
- Sp100: Indicates antibodies against the Sp100 protein, which are associated with PBC.
- gp210: Indicates antibodies against the gp210 protein, which are associated with PBC.
- LKM1: Indicates the presence of anti-liver kidney microsomal antibodies type 1, which are associated with autoimmune hepatitis type 2 (AIH-2).
- LC1: Indicates the presence of antibodies against the LC1 protein, which are associated with AIH-2.
- SLA: Indicates the presence of antibodies against the SLA protein, which are associated with AIH.
Together, these markers provide valuable insights for diagnosing and classifying autoimmune liver diseases, particularly when clinical signs overlap or mimic other liver conditions.
AMA-M2 LIA
SP100
LKM1
GP210
LC1
SLA
Frequently Asked Questions about Autoimmune Liver Diseases IgG Profile, LIA
Q. What is the Autoimmune Liver Diseases IgG Profile, LIA?
Q. Why do I need this test?
Q. What antibodies does this test check for?
Q. Do I need to fast before this test?
Q. How is the Autoimmune Liver Diseases IgG Profile, LIA performed?
Q. Is there any risk associated with the Autoimmune Liver Diseases IgG Profile, LIA?
Q. How frequently should I get the Autoimmune Liver Diseases IgG Profile, LIA done?
Q. Can autoimmune liver diseases be cured?
Q. How does Tata 1mg ensure accurate lab test results?
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References
- Fallatah HI, Akbar HO. Elevated serum immunoglobulin G levels in patients with chronic liver disease in comparison to patients with autoimmune hepatitis. Libyan J Med. 2010 Jan 25;5. https://pmc.ncbi.nlm.nih.gov/articles/PMC3071169/
- Antimitochondrial Antibody and Antimitochondrial M2 Antibody [Internet]. Rochester, NY: University of Rochester Medical Center; [Accessed 30 Jun. 2025]. Available from: https://www.urmc.rochester.edu/encyclopedia/content.aspx?contenttypeid=167&contentid=antimitochondrial_antibody_m2
- Kerkar N, Ma Y, Davies ET, Cheeseman P, Mieli-Vergani G, Vergani D. Detection of liver kidney microsomal type 1 antibody using molecularly based immunoassays. J Clin Pathol. 2002 Dec;55(12):906-9. [Accessed 30 Jun. 2025]. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1769836/
- Zeman MV, Hirschfield GM. Autoantibodies and liver disease: uses and abuses. Can J Gastroenterol. 2010 Apr;24(4):225-31. [Accessed 30 Jun. 2025]. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2864616/
- Linzay CD, Sharma B, Pandit S. Autoimmune Hepatitis. [Updated 2023 Aug 14]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK459186/
- Terziroli Beretta-Piccoli B, Mieli-Vergani G, Vergani D. Autoimmune Hepatitis: Serum Autoantibodies in Clinical Practice. Clin Rev Allergy Immunol. 2022 Oct;63(2):124-137. [Accessed 30 Jun. 2025]. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9464171/
- Sebode M, Weiler-Normann C, Liwinski T, Schramm C. Autoantibodies in Autoimmune Liver Disease-Clinical and Diagnostic Relevance. Front Immunol. 2018 Mar 27;9:609. [Accessed 30 Jun. 2025]. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5880919/
- Mercado LA, Gil-Lopez F, Chirila RM, Harnois DM. Autoimmune Hepatitis: A Diagnostic and Therapeutic Overview. Diagnostics (Basel). 2024 Feb 9;14(4):382. [Accessed 30 Jun. 2025].
- Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10887775/
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