Arthritis Checkup Advanced
Understanding Arthritis Checkup Advanced
What is Arthritis Checkup Advanced?
The Arthritis Checkup Advanced helps assess the severity and type of arthritis, a condition marked by joint inflammation and stiffness. This profile includes blood tests that provide insights into the inflammation levels, autoimmune responses, and specific markers related to various forms of arthritis.
Arthritis is a common condition that causes pain, stiffness, and discomfort in the joints. It can affect people in different ways, with varying symptoms and severity impacting on daily life. As a result, timely and accurate diagnosis is critical for developing an appropriate treatment plan to reduce pain, manage inflammation, and prevent further joint damage.
The Arthritis Checkup Advanced is essential in diagnosing different problems affecting joints, such as rheumatoid arthritis, osteoarthritis, gout, lupus, and psoriatic arthritis. These tests provide valuable information on inflammatory markers, autoantibodies, and other biomarkers linked to the condition. For example, tests like C-reactive protein (CRP) and rheumatoid factor (RF) can show inflammation levels and help identify autoimmune arthritis. Other tests, such as Anti-Cyclic Citrullinated Peptide (Anti-CCP), can help detect rheumatoid arthritis early, while Anti-Nuclear Antibody (ANA) can point to autoimmune conditions like lupus. Uric Acid test helps diagnose gout, and the Erythrocyte Sedimentation Rate (ESR) helps assess inflammation. The Anti-Streptolysin O (ASO) Titer measures antibodies against Streptococcus bacteria, and elevated levels may indicate a past infection that could trigger reactive arthritis. A Complete Blood Count (CBC) gives a general overview of the health. Additionally, Complement 3 and Complement 4 are tested to evaluate the immune system’s activity, as abnormalities in complement proteins can be seen in autoimmune conditions like lupus and rheumatoid arthritis. All these tests help doctors create a treatment plan that fits specific disease types and needs. This information enables doctors to determine the most effective treatment plan for each patient's unique condition.
Consider getting tested if there are symptoms like joint pain, swelling, stiffness, or reduced mobility, as these may signal an underlying form of arthritis or other joint-related conditions. It’s also important to get tested if there are risk factors such as aging, a family history of arthritis, obesity, or previous joint injuries.
Usually, overnight fasting (8 to 12 hours) is preferred before going for an Arthritis Checkup Advanced. However, drinking water is acceptable. It is important to inform the doctor about other medications or supplements being taken, as they might interfere with test results, necessitating a temporary cessation.
Lab test results may vary across different laboratories. Abnormal test results require an expert interpretation. Therefore, never try to self-medicate at home based solely on these results, and always consult a doctor for a proper understanding of the test results. Discuss the symptoms and medical history to help the doctor correlate the clinical and laboratory findings, leading to a more accurate diagnosis and an effective treatment plan tailored to the specific health needs. The doctor may suggest lifestyle modifications, including dietary changes, stress management techniques, and ergonomic adjustments for arthritis management.
What is Arthritis Checkup Advanced used for?
The Arthritis Checkup Advanced is done:
- To facilitate early detection of arthritis, potentially preventing joint damage and improving long-term outcomes.
- To identify the type and severity of arthritis.
- To differentiate between various types of arthritis.
- To track arthritis progression and treatment response over time.
- To test for autoimmune antibodies like rheumatoid factor (RF) to detect autoimmune-related conditions.
- To assess specific biomarkers associated with arthritis to guide diagnosis and treatment.
- To help identify individuals at risk of developing arthritis or experiencing disease manifestations.
- In individuals with risk factors like a family history of arthritis, obesity, etc.
- To assess overall joint health and inflammation in the body.
What does Arthritis Checkup Advanced measure?
Contains 30 testsThe Arthritis Checkup Advanced measures various markers related to joint inflammation, immune response, and disease activity. Some key tests include C-reactive protein (CRP), which tracks inflammation and helps monitor arthritis activity and treatment progress. Rheumatoid Factor (RF) detects antibodies often found in rheumatoid arthritis, helping distinguish it from other types of arthritis. Anti-Cyclic Citrullinated Peptide (Anti-CCP) antibodies are often elevated in rheumatoid arthritis and can help with early diagnosis. Complement 3 and Complement 4 proteins assess immune system function and may indicate autoimmune conditions like lupus and rheumatoid arthritis when abnormal. Uric Acid levels help detect gout, where crystals build up in the joints. Anti-Nuclear Antibody (ANA) tests for autoimmune diseases like lupus, which can cause joint inflammation. The Anti-Streptolysin O (ASO) Titer measures antibodies against Streptococcus bacteria, which might lead to reactive arthritis. The Erythrocyte Sedimentation Rate (ESR) is a general marker of inflammation, and the Complete Blood Count (CBC) checks overall health, detecting infections or anemia that could contribute to arthritis symptoms. These tests help doctors understand the type, severity, and treatment response of arthritis, allowing them to create personalized treatment plans that reduce inflammation and improve joint health.
ESR (Erythrocyte Sedimentation Rate)
An ESR test measures the rate at which red blood cells (erythrocytes) settle (sediment) in one hour at the bottom of a tube that contains a blood sample.
When there is inflammation in the body, certain proteins, mainly fibrinogen, increase in the blood. This increased amount of fibrinogen causes the red blood cells to form a stack (rouleaux formation) that settles quickly due to its high density, leading to an increase in the ESR.
An ESR test is a non-specific measure of inflammation and can be affected by conditions other than inflammation. This test cannot identify the exact location of the inflammation in your body or what is causing it. Hence, an ESR test is usually performed along with a few other tests to identify or treat possible health concerns.
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CBC (Complete Blood Count)
The CBC (Complete Blood Count) test measures the number of red blood cells (RBCs), white blood cells (WBCs), and platelets. Each of these blood cells performs essential functions–RBCs carry oxygen from your lungs to the various body parts, WBCs help fight infections and other diseases, and platelets help your blood to clot–so determining their levels can provide significant health information. A CBC test also determines the hemoglobin level, a protein in RBC that carries oxygen from the lungs to the rest of your body. Evaluating all these components together can provide important information about your overall health.
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Differential Leukocyte Count
- Differential Basophil Count
- Differential Neutrophil Count
- Differential Lymphocyte Count
- Differential Monocyte Count
- Differential Eosinophil Count
There are five types of WBCs: neutrophils, lymphocytes, monocytes, eosinophils, and basophils. A Differential Leukocyte Count test measures the percentage of each type of WBC in the blood. Leukocytes or WBCs are produced in the bone marrow and defend the body against infections and diseases. Each type of WBC plays a unique role to protect against infections and is present in different numbers.
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Red Blood Cell Count
The Red Blood Cell Count test measures the total number of red blood cells in your blood. RBCs are the most abundant cells in the blood with an average lifespan of 120 days. These cells are produced in the bone marrow and destroyed in the spleen or liver. Their primary function is to help carry oxygen from the lungs to different body parts. The normal range of RBC count can vary depending on age, gender, and the equipment and methods used for testing.
Hb (Hemoglobin)
An Hb (Hemoglobin) test measures the concentration of hemoglobin protein in your blood. Hemoglobin is made up of iron and globulin proteins. It is an essential part of RBCs and is critical for oxygen transfer from the lungs to all body tissues. Most blood cells, including RBCs, are produced regularly in your bone marrow. The Hb test is a fundamental part of a complete blood count (CBC) and is used to monitor blood health, diagnose various blood disorders, and assess your response to treatments if needed.
Platelet Count
The Platelet Count test measures the average number of platelets in the blood. Platelets are disk-shaped tiny cells originating from large cells known as megakaryocytes, which are found in the bone marrow. After the platelets are formed, they are released into the blood circulation. Their average life span is 7-10 days.
Platelets help stop the bleeding, whenever there is an injury or trauma to a tissue or blood vessel, by adhering and accumulating at the injury site and releasing chemical compounds that stimulate the gathering of more platelets. A loose platelet plug is formed at the site of injury and this process is known as primary hemostasis. These activated platelets support the coagulation pathway that involves a series of steps, including the sequential activation of clotting factors; this process is known as secondary hemostasis. After this step, there is a formation of fibrin strands that form a mesh incorporated into and around the platelet plug. This mesh strengthens and stabilizes the blood clot so that it remains in place until the injury heals. After healing, other factors come into play and break the clot down so that it gets removed. In case the platelets are not sufficient in number or not functioning properly, a stable clot might not form. These unstable clots can result in an increased risk of excessive bleeding.
Total Leukocyte Count
The Total Leukocyte Count test measures the numbers of all types of leukocytes, namely neutrophil, lymphocyte, monocyte, eosinophil, and basophil, in your blood. Leukocytes or WBCs are an essential part of our immune system. These cells are produced in the bone marrow and defend the body against infections and diseases. Each type of WBC plays a unique role to protect against infections and is present in different numbers.
Hematocrit
The Hematocrit test measures the proportion of red blood cells (RBCs) in your blood as a percentage of the total blood volume. It is a crucial part of a complete blood count (CBC) and helps in assessing your blood health. RBCs are responsible for carrying oxygen from the lungs to different parts of the body. The hematocrit test provides valuable information about your blood's oxygen-carrying capacity.
Higher-than-normal amounts of RBCs produced by the bone marrow can cause the hematocrit to increase, leading to increased blood density and slow blood flow. On the other hand, lower-than-normal hematocrit can be caused by low production of RBCs, reduced lifespan of RBCs in circulation, or excessive bleeding, leading to a reduced amount of oxygen being transported by RBCs. Monitoring your hematocrit levels is essential for diagnosing and managing various blood-related disorders.
Mean Corpuscular Volume
The Mean Corpuscular Volume test measures the average size of your red blood cells, which carry oxygen through your body. This test tells whether your RBCs are of average size and volume or whether they are bigger or smaller.
Mean Corpuscular Hemoglobin
An MCH test measures the average amount of hemoglobin in a single red blood cell (RBC). Hemoglobin is an iron-containing protein in RBCs, and its major function is to transport oxygen from the lungs to all body parts. This test provides information about how much oxygen is being delivered to the body by a certain number of RBCs.
Mean Corpuscular Hemoglobin Concentration
An MCHC test measures the average amount of hemoglobin in a given volume of RBCs. MCHC is calculated by dividing the amount of hemoglobin by hematocrit (volume of blood made up of RBCs) and then multiplying it by 100.
Mean Platelet Volume
An MPV test measures the average size of the platelets in your blood. Platelets are disk-shaped tiny cells originating from large cells known as megakaryocytes, which are found in the bone marrow. After the platelets are formed, they are released into the blood circulation. Their average life span is 7-10 days.
Platelets help stop bleeding whenever there is an injury or trauma to a tissue or blood vessel by adhering and accumulating at the injury site, and by releasing chemical compounds that stimulate the gathering of more platelets. After these steps, a loose platelet plug is formed at the site of injury, and this process is known as primary hemostasis. These activated platelets support the coagulation pathway that involves a series of steps including the sequential activation of clotting factors; this process is known as secondary hemostasis. After this, there is a formation of fibrin strands that form a mesh incorporated into and around the platelet plug. This mesh strengthens and stabilizes the blood clot so that it remains in place until the injury heals. After healing, other factors come into play and break the clot down so that it gets removed. In case the platelets are not sufficient in number or are not functioning properly, a stable clot might not form. These unstable clots can result in an increased risk of excessive bleeding.
PDW
The PDW test reflects variability in platelet size, and is considered a marker of platelet function and activation (clot formation in case of an injury). This marker can give you additional information about your platelets and the cause of a high or low platelet count. Larger platelets are usually younger platelets that have been recently released from the bone marrow, while smaller platelets may be older and have been in circulation for a few days. Higher PDW values reflect a larger range of platelet size, which may result from increased activation, destruction and consumption of platelets.
RDW CV
The RDW CV test which is part of red cell indices, helps identify characteristics of red blood cells. RDW (red cell distribution width) measures the variations in the sizes of red blood cells, indicating how much they differ from each other in a blood sample. RDW is expressed as RDW-CV, a coefficient of variation. A higher RDW may suggest more variation in red cell sizes, while a lower RDW indicates more uniform red cell sizes.
Absolute Leucocyte Count
- Absolute Eosinophil Count
- Absolute Neutrophil Count
- Absolute Basophil Count
- Absolute Monocyte Count
The Absolute Leucocyte Count test measures the total number of white blood cells (leucocytes) in the given volume of blood. It examines different types of white blood cells such as neutrophils, lymphocytes, monocytes, basophils and eosinophils. These cells tell about the status of the immune system and its ability to fight off infections and other conditions like inflammation, allergies, bone marrow disorders etc.
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CRP (C-Reactive Protein), Quantitative
The CRP test measures the levels of C-reactive protein in your body. This test helps detect the presence of inflammation in the body. It is a non-specific test as it cannot diagnose a condition by itself or determine its exact location or cause.
CRP is an acute phase reactant protein produced by the liver in response to an inflammation in the body. This inflammation may be due to tissue injury, infection, autoimmune diseases, or cancer. CRP levels are often increased before the onset of other symptoms of inflammation, such as pain, redness, fever, or swelling. These levels fall as the inflammation subsides.
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Rheumatoid Factor - Quantitative
The Rheumatoid Factor - Quantitative test detects and measures the concentration of rheumatoid factor (RF), an antibody produced by the immune system, in your blood. Increased levels of rheumatoid factor can be detected in the blood in certain autoimmune conditions, particularly rheumatoid arthritis. However, an RF test is not very specific as a rheumatoid factor can also be found in the body in diseases other than RA, such as Sjögren’s syndrome and systemic lupus erythematosus (SLE). RF may also be produced in the body during persistent bacterial and viral infections. Hence, clinical evaluation and other diagnostic tests are crucial for a comprehensive assessment and accurate diagnosis.
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Uric Acid
An Uric Acid test determines the level of uric acid in your body. Uric acid is a nitrogenous compound produced by the metabolic breakdown of purine. Purines are present as nitrogenous bases in the DNA and are also found in food like red meat and seafood.
Most uric acid dissolves in the blood and goes into your kidneys. From there, it passes through your body via the urine. Decreased elimination of uric acid is often a result of impaired kidney function due to kidney disease. In many cases, the exact cause of excess uric acid is unknown. Doctors seldom need to test for low levels of uric acid.
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Anti-Nuclear Antibody (ANA) by IFA - End Point Titer
An Anti-Nuclear Antibody (ANA) by IFA - End Point Titer test checks for antinuclear antibodies (ANA) in your blood. These antibodies, different from typical ones that fight off invaders in the body, can attach to structures inside the body’s own cell nuclei. If ANAs are present in the blood, it may suggest that your immune system is overly sensitive, causing inflammation against your own tissues and possibly indicating autoimmune diseases.
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Anti Streptolysin O Titer
The Anti Streptolysin O Titer test measures the level of antibodies in the blood that target streptolysin O, a homogeneous exotoxin produced by the Streptococcus pyogenes bacteria. When the body is infected with this bacteria, it produces antibodies, including ASO, as part of the immune response to neutralize the toxin. The ASO titres quantifies the concentration of ASO antibodies in the bloodstream, signaling the body’s immune response to a recent or ongoing streptococcal infection.
An abnormal or positive test result means you recently had a streptococcal infection, even if you had no symptoms. Additionally, monitoring ASO levels over time can help assess the efficacy of the treatment and detect any potential complication, such as rheumatic fever or acute glomerulonephritis which may arise as a result of streptococcal infection. Therefore, the Anti Streptolysin O Titer test plays an important role in diagnosing and managing streptococcal infections and associated conditions.
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Anti-CCP Antibody
An Anti-CCP Antibody test measures the presence of antibodies against cyclic citrullinated peptides (CCP) in the blood. These antibodies are collectively referred to as anti-CCP antibodies. Citrullination is a process where the amino acid arginine is converted to citrulline. In autoimmune diseases, such as rheumatoid arthritis (RA), the immune system may mistakenly identify citrullinated peptides as foreign invaders and produce antibodies against them.
Anti-CCP antibodies are considered one of the early markers of rheumatoid arthritis. They contribute to the chronic inflammation and joint damage characteristic of RA. Their presence in the blood can aid in the early diagnosis of RA, establish a prognosis for disease progression, and allow timely intervention and management.
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Answers to Patient Concerns & Frequently Asked Questions (FAQs) about Arthritis Checkup Advanced
Frequently Asked Questions about Arthritis Checkup Advanced
Q. Why is the Arthritis Checkup Advanced important?
Q. Who should consider getting the Arthritis Checkup Advanced?
Q. How is the Arthritis Checkup Advanced performed?
Q. What tests are included in the Arthritis Checkup Advanced?
Q. Is there any risk associated with the Arthritis Checkup Advanced?
Q. How often should the Arthritis Checkup Advanced be done?
Q. Can arthritis be cured?
Q. Is arthritis hereditary?
Q. Is arthritis only a disease of the elderly?
Q. How does Tata 1mg ensure accurate lab test results?
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References
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- Ashai S, Harvey NC. Rheumatoid arthritis and bone health. Clin Med (Lond). 2020 Nov;20(6):565-567. doi: 10.7861/clinmed.20.6.rabh. PMID: 33199321; PMCID: PMC7687316. [Accessed 29 Jan. 2025]. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7687316/
- Gout [Internet]. CDC; 26 Jun. 2025 [Accessed 29 Jan. 2025]. Available From: https://www.cdc.gov/arthritis/gout/?CDC_AAref_Val=https://www.cdc.gov/arthritis/types/gout.html
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