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Apolipoproteins A1 & B

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3 tests

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The Apolipoproteins A1 & B test measures the amount of Apolipoprotein A1 and Apolipoprotein B along with Apolipoprotein B/A1 ratio in your blood. This test provides valuable insights into an individual’s heart health by evaluating your risk of developing cardiovascular disease (CVD) such as heart attack, and stroke that can be life-threatening if left untreated.

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Overnight fasting required for 8 to 12 hours

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Understanding Apolipoproteins A1 & B

Apolipoprotein A1 and B are biomarkers, also known as cardiac risk markers, that show up in the blood after your heart has been under severe stress or injury. These markers are valuable indicators that healthcare advisors can utilize for a more comprehensive assessment of cardiac risk factors and to tailor preventive measures and treatments.

Apolipoproteins A is a protein that comprises around 70% of the protein in HDL (good cholesterol) and facilitates the transportation of cholesterol to the liver, where it is degraded. Whereas, Apolipoprotein B is primarily associated with low-density lipoprotein (LDL), a type of bad cholesterol. Elevated levels of Apo-B are associated with an increased risk of atherosclerosis, the process involving the buildup of plaque (harmful fats, cholesterol, and other substances), in the arteries (blood vessels that carry blood). This buildup can lead to heart attacks, strokes, and other cardiovascular diseases. In addition, the Apolipoprotein B/A1 ratio helps predict the risk of cardiovascular disease (CVD) in individuals at high risk or who have had similar health issues in the past. Elevated ApoB and decreased ApoA1 are associated with increased risk of cardiovascular disease. Therefore, understanding your Apo A1 and Apo B levels can be an important part of managing your overall heart health.

The Apolipoproteins A1 & B is especially useful when standard cholesterol tests, such as LDL cholesterol levels, may not provide a complete picture of cardiovascular risk. Your doctor may advise this test if you experience symptoms suggestive of heart disease or cardiovascular problems, such as chest pain, shortness of breath, palpitations or other cardiac symptoms. The Apolipoproteins A1 & B test is also recommended if you have risk factors such as high blood pressure, high cholesterol, obesity, diabetes, smoking, or a family history of heart disease or chronic conditions like diabetes, high blood pressure, etc. This test is also recommended to monitor the effectiveness of ongoing treatment in individuals already diagnosed with cardiovascular disease.

Usually, overnight fasting is preferred for this test. Do not eat or drink anything except water before the test. It is important to inform your doctor about any heart medications or supplements you are taking, as some could impact the test results. Always seek your doctor’s advice before altering any medication routine.

Test result ranges are approximate and may differ slightly between labs depending on the methodology and laboratory guidelines. Talk to your doctor about your specific test results. The results of this test can guide your doctor to suggest lifestyle changes, medication management, and other interventions to reduce the risk of heart disease and improve heart health.

What does Apolipoproteins A1 & B measure?

Contains 3 tests

The Apolipoproteins A1 & B test helps check the levels of Apolipoproteins in your blood. It contains three tests namely, Apolipoprotein - A1, Apolipoprotein - B, and Apolipoprotein B/A1 ratio. Apolipoprotein - A1 is the primary protein associated with HDL cholesterol (good cholesterol) and its increased concentrations are associated with reduced risk of cardiovascular disease. Apolipoprotein B is the primary protein associated with LDL cholesterol (bad cholesterol) and other lipid molecules. An increase in LDL cholesterol is associated with increased risk of cardiovascular disease. While the apolipoprotein B/A1 ratio compares the values of Apo B to ApoA1 and an elevated ApoB:ApoA1 ratio confers increased risk of atherosclerotic cardiovascular disease.

Getting tested with the Apolipoproteins A1 & B test can help lower your risk for cardiovascular disease and ensure that you live a longer, healthier life.

Apolipoprotein - B

The Apolipoprotein - B test measures the level of Apo B in the blood. The protein helps in transporting fats and cholesterol within the body. Apo B is a central component of some fat-carrying particles in the blood, such as very low-density lipoprotein (VLDL), low-density lipoprotein (LDL), and chylomicrons. It binds to LDL or "bad" cholesterol, which may result in plaque developing in the blood vessels. This accumulation can lead to heart disease, which can become grave or life-threatening if left untreated.

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Apolipoprotein B/A1 Ratio

An Apolipoprotein B/A1 Ratio test helps predict the risk of cardiovascular disease (CVD) in individuals at high risk, such as those who are obese, have a family history of heart disease, have high cholesterol, or have had similar health issues in the past. Apolipoprotein A1 is the primary protein associated with HDL cholesterol (good cholesterol), and its increased concentrations are associated with a reduced risk of cardiovascular disease. Apolipoprotein B is the primary protein associated with LDL cholesterol (bad cholesterol) and other lipid molecules. An increase in LDL cholesterol is associated with increased risk of cardiovascular disease. Therefore, an Apolipoprotein B/A1 Ratio test is a key marker of developing potential cardiovascular disease (CVD) or heart-related ailments.

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Apolipoprotein - A1

An Apolipoprotein - A1 test helps check the levels of Apolipoprotein A1 in your blood. Apolipoprotein A1 is the major protein for the high-density lipid (HDL), also known as “good” cholesterol and helps in its transport. Apo A1 helps the HDL to take up cholesterol from the tissues and is bound by receptors in the liver where the cholesterol is destroyed. Assessing the levels of Apolipoprotein A1 directly reflects the high-density lipoprotein levels. In this way, apolipoprotein A can help to lower your risk for cardiovascular disease.

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FAQs related to Apolipoproteins A1 & B

Why is the Apolipoproteins A1 & B test done?

The Apolipoproteins A1 & B test is done to evaluate the levels of Apo-B and Apo-A1 in your blood. It helps in assessing your risk for developing cardiovascular diseases such as heart attack, atherosclerosis, stroke, etc.

When should I take the {test_name] test?

Your doctor may recommend an Apolipoprotein A1 and B test if you have a family history of heart disease or if you’ve already been diagnosed with heart disease. The test can help show how well your treatment is working.

How frequently should I undergo the Apolipoproteins A1 & B test?

The frequency of the Apolipoproteins A1 & B test depends on your individual health factors such as age, family history of heart ailments, lifestyle habits, and existing health conditions like diabetes, high blood pressure, etc. It is best to discuss with your doctor to decide how often you need this test based on your individual health needs and risks.

Do I need to fast before the Apolipoproteins A1 & B test?

It is preferable if you are fasting before the Apolipoproteins A1 & B test; this means not eating or drinking anything other than water for 8 to 12 hours before the test, however, it is not mandatory. Follow all the instructions thoroughly given by your healthcare provider.

What factors can affect the result of the Apolipoproteins A1 & B test?

The factors that can affect Apolipoproteins A1 & B test results include age, gender, genetic factors or family history of heart disease, diet, smoking, alcohol consumption, and the use of certain medications such as androgens, beta-blockers, diuretics, or progestins (synthetic progesterones).

What can I do if my Apolipoproteins A1 & B test result is abnormal?

Abnormal Apolipoproteins A1 & B test results might suggest an increased risk of heart disease. It is best to consult your doctor regarding your test results. Measures such as lifestyle and dietary modifications, and the use of certain medications (if prescribed by your doctor) may help manage these risks effectively.

What are the warning signs and symptoms that might indicate a heart condition?

The warning signs of heart disease can vary, but some common symptoms include chest pain, palpitations, shortness of breath, irregular heartbeat, fatigue, dizziness etc. Sometimes, symptoms might not be as obvious, so it's essential to pay attention to any unusual feelings in your chest, or sudden fatigue during daily activities. Seek medical help promptly if you experience severe or persistent symptoms.

What other tests might I have along with this test?

You may need the following tests along with Apolipoproteins A1 & B test: Lipid profile, LDL cholesterol, HDL cholesterol, Triglycerides, Total cholesterol, etc.

How does Tata 1mg ensure accurate lab test results?

Tata 1mg ensures accurate lab test results through certified laboratories that use advanced technology and adhere to stringent quality control measures. This commitment to high standards guarantees reliable results.

Content created by

Dr. Swati Gupta (Anand)

MBBS, MD Lab Medicine

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Last Updated

6th Oct 2025