IGF Binding Protein-3
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What is IGF Binding Protein-3?
The Insulin like Growth Factor Binding Protein 3 is one of 6 proteins that binds to the Insulin like Growth Factor hormone secreted from the liver and transports it through the bloodstream to the target organs. The IGFBP 3 protein levels increase or decrease with the human Growth Hormone secreted by the pituitary glands. Oversecretion of Growth Hormone causes gigantism or acromegaly, and under secretion causes dwarfism. Thus, the IGFBP 3 levels serve to reflect on the levels of growth hormone, and are used to diagnose under or over secretion of Growth Hormone.
Why is IGF Binding Protein-3 done?
- To diagnose disorders of growth due to under or over secretion of Growth Hormone in children and adults
- To check the efficacy of treatment of growth disorders using recombinant human growth hormone
- As a possible adjunct to insulin-like growth factor 1 and growth hormone in the diagnosis and follow-up of acromegaly and gigantism