Overview of Thyroxine Binding Globulin
What is Thyroxine Binding Globulin?
Sample Type
Preparation for Thyroxine Binding Globulin
- No special preparation required
Why Get Tested for Thyroxine Binding Globulin?
To diagnose hypothyroidism (low levels of thyroid)
To diagnose hyperthyroidism (high levels of thyroid)
To monitor treatment in patients with thyroid disease
Understand more about Thyroxine Binding Globulin
TBG is a serum binding protein which has a high affinity to bind to T3 and T4. In the routine, the thyroid gland maintains the level of free hormone i.e. which is not bound to the TBG. This test is done to assess the thyroid tissues. It helps in diagnosing thyroid disorders such as hypothyroidism and hyperthyroidism. The rise in levels is associated with the intake of oral contraceptives or estrogen therapy. In conditions such as pregnancy or if a person has family history elevated levels of TBG are seen. The decrease in TBG levels is associated with intake of androgenic steroids, heavy doses of glucocorticoids, liver disease, nephrotic syndrome, congenital TGB variants and hypoproteinemic states.
What Results of Thyroxine Binding Globulin mean?
Interpretations
High levels may indicate:
Liver disease
Acute intermittent porphyria
Hypothyroidism
Low levels may indicate:
Acromegaly
Acute illness
Hyperthyroidism
Malnutrition
Nephrotic Syndrome
Patient Concerns about Thyroxine Binding Globulin
Frequently Asked Questions about Thyroxine Binding Globulin
Provided By
NABL
CAP