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Oxaprozin is used to relieve swelling, stiffness, pain and tenderness caused by rheumatoid arthritis (inflammatory disorder that typically affects the small joints in hands and feet), osteoarthritis (a type of joint disease that causes stiffness, pain and loss of joint movement) or juvenile arthritis (childhood arthritis).

How it works

Oxaprozin is a painkiller that belongs to class of medications called non-steroidal anti-inflammatory drugs (NSAIDs). It works by inhibiting the production of a chemical prostaglandin in body thereby relieving pain, fever, and inflammation.

Common side effects

Nausea, Liver enzyme increased, Abdominal pain, Anemia, Confusion, Constipation, Depression, Diarrhoea, Dizziness, Difficulty in urination, Edema, Flatulence, Gastrointestinal perforation, Gastrointestinal bleeding, Headache, Heartburn, Increased bleeding time, Indigestion, Insomnia, Itching, Loss of appetite, Rash, Renal disorder, Ringing in ear, Sedation, Sleeping for unusually long periods, Ulcer, Vomiting


Expert advice

  • Seek immediate medical attention if you see signs of blood, heart or stomach problems, shortness of breath, slurred speech, chest pain, or weakness in one part or side of the body as oxaprozin may cause increased risk of stroke, serious blood disorders, myocardial infarction (heart attack), gastric bleeding, ulceration, and perforation of the stomach or intestines.
  • Do not start oxaprozin if you have had any heart disease, edema (swelling), blood disorders, kidney, stomach, liver problems, diabetes, high cholesterol, asthma, skin allergy or photosensitivity (high sensitivity to sunlight), have poor health, low fluid volume, dehydration.
  • Take precautions while taking oxaprozin if you are an elderly.
  • Tell your doctor if you undergo surgery including dental while on oxaprozin treatment.
  • Avoid prolonged exposure to sunlight and wear protective clothes sunglasses and sunscreen when you go in sunlight whole on oxaprozin treatment.
  • Do not consume alcohol while taking oxaprozin as it may worsen the side effects.
  • Tell your doctor if you are or planning to become pregnant or are breastfeeding.

Frequently asked questions


Q. Is oxaprozin a narcotic, painkiller, opiate or benzodiazepine?
Oxaprozin is not a narcotic, an opiate or a benzodiazepine. It is a non-steroidal anti-inflammatory drug.
Q. Is oxaprozin like Vicodin (acetaminophen and hydrocodone)?
Oxaprozin and Vicodin (acetaminophen and hydrocodone) belong to different class of pain killers.

Q. Does oxaprozin contains aspirin, acetaminophen or codeine?
 Oxaprozin does not contain aspirin, acetaminophen or codeine.
Q. Is oxaprozin addictive?
Oxaprozin is not addictive. But it can be misused or excessively abused for pain relief.
Q. Is oxaprozin an antiarrhythmic, muscle relaxer, blood thinner?
Oxaprozin is not an antiarrhythmic, muscle relaxer or blood thinner.
Q. Can I take oxaprozin with ibuprofen, Vicodin, Aleve, acetaminophen (Tylenol), hydrocodone?
Oxaprozin when taken with ibuprofen, acetaminophen (Tylenol), Vicodin (acetaminophen and hydrocodone), naproxen (Aleve) can lead to increased side effects.
Q. Does oxaprozin get you high, make you drowsy, sleepy or cause weight gain?
Oxaprozin does not get you high. However, it can cause drowsiness and sleepiness, and weight loss.

Content on this page was last updated on 15 October, 2016, by Dr. Varun Gupta (MD Pharmacology)