Zestgab Plus Tablet

Alpha Lipoic Acid (300mg)+ L-Methyl Folate Calcium (0.5mg)+ Methylcobalamin (750mcg)+ Pregabalin (75mg)+ Pyridoxal-5-phosphate (10mg)

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Zestgab Plus Tablet is a combination medicine used to treat neuropathic pain. It works by protecting the nerve fibers against damage, repairing the damaged nerves, thereby relieving the pain sensation.

Written By Dr. Subita Alagh, BDS,
Reviewed By Dr. Rajeev Sharma, MBA, MBBS,
Last updated on 23 May 2026 | 09:58 AM (IST)

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General Information

Contains

Alpha Lipoic Acid (300mg)+ L-Methyl Folate Calcium (0.5mg)+ Methylcobalamin (750mcg)+ Pregabalin (75mg)+ Pyridoxal-5-phosphate (10mg)

Marketer

Hemmispheres Pharma Private Limited

Storage

Store below 30°C

The content is shown in English

Product introduction

Zestgab Plus Tablet may be taken with or without food. However, it is advised to take it at the same time each day as this helps to maintain a consistent level of medicine in the body. Take this medicine in the dose and duration advised by your doctor. If you miss a dose of this medicine, take it as soon as you remember. Finish the full course of the treatment even if you feel better. It is important not to stop taking this medicine suddenly.

Some common side effects of this medicine include tiredness and uncoordinated body movements. It may also cause dizziness and sleepiness, so do not drive or do anything that requires mental focus until you know how this medicine affects you. However, these are temporary and usually resolve on their own. Please consult your doctor if these do not subside or bother you.

You should avoid alcohol while taking Zestgab Plus Tablet, as it may worsen certain side effects. This medicine can also lead to weight gain, eat a healthy balanced diet, avoid snacking with high-calorie food, and exercise regularly. Inform your doctor if you develop any unusual changes in mood or behavior, new or worsening depression, or suicidal thoughts or behavior.

Uses of Zestgab Plus Tablet

Neuropathic pain

Benefits of Zestgab Plus Tablet

Neuropathic pain
Neuropathic pain occurs due to nerve damage, often seen in conditions like diabetes, shingles, or spinal injuries. Zestgab Plus Tablet is used to relieve this nerve-related pain. It reduces abnormal nerve signals that cause pain, supports nerve repair, reduces nerve damage, and improves overall nerve health. It helps ease pain, tingling, and numbness, and improves quality of life.

Side effects of Zestgab Plus Tablet

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Zestgab Plus

Dizziness
Sleepiness
Tiredness
Uncoordinated body movements

How to use Zestgab Plus Tablet

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Zestgab Plus Tablet may be taken with or without food.

How Zestgab Plus Tablet works

Zestgab Plus Tablet is a combination of four nutritional supplements (Alpha Lipoic Acid, L-Methyl Folate Calcium, Methylcobalamin, Pyridoxal-5-phosphate) and a neuroactive medicine (Pregabalin). The nutritional supplements work by protecting the nerve fibres and promoting nerve repair. The neuroactive medicine decreases pain by modulating calcium channel activity of the nerve cells. Together, they relieve neuropathic pain (pain from damaged nerves).

Quick tips

Zestgab Plus Tablet is used to treat certain types of long-lasting pain caused by damage to nerves.
Inform your doctor if you are taking any other pain-relieving medicines.
Along with taking Zestgab Plus Tablet, your doctor might advise you to undergo physiotherapy to get relief from pain.
Let your doctor know if you are pregnant or breastfeeding.

Safety advice

Alcohol

UNSAFE

Do not drink alcohol while you are taking this medicine. Zestgab Plus Tablet may cause excessive drowsiness when taken with alcohol.

Pregnancy

CONSULT YOUR DOCTOR

The safety of Zestgab Plus Tablet during pregnancy has not been established. There are no adequate and well-controlled studies in pregnant women, and animal data on reproductive toxicity are insufficient. Your doctor will weigh the benefits and any potential risks before prescribing.

Breast feeding

CONSULT YOUR DOCTOR

Zestgab Plus Tablet may be unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby. It should be used only if the expected benefit outweighs the potential risk. Please consult your doctor.

Driving

UNSAFE

Zestgab Plus Tablet may decrease alertness, affect your vision, or make you feel sleepy and dizzy. Do not drive if these symptoms occur.

Kidney

CAUTION

Zestgab Plus Tablet should be used with caution in patients with severe kidney disease. Dose adjustment may be needed.

Liver

CAUTION

Zestgab Plus Tablet should be used with caution in patients with liver disease. Dose adjustment may be needed.

Fact Box

Habit Forming

Therapeutic Class

NEURO CNS

References

Stahl SM, editor. Pregabalin. In: Stahl's Essential Pschopharmacology: Prescriber's Guide. 5th ed. New York, New York: Cambridge University Press; 2014. pp. 557-60.
McNamara JO. Pharmacotherapy of the Epilepsies. In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. 12th ed. New York, New York: McGraw-Hill Medical; 2011. p. 599.
Porters RJ, Meldrum BS. Antiseizure Drugs. In: Katzung BG, Masters SB, Trevor AJ, editors. Basic and Clinical Pharmacology. 11th ed. New Delhi, India: Tata McGraw Hill Education Private Limited; 2009. p. 410.

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Disclaimer

Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: Hemmispheres Pharma Private Limited
Address: #6-3-609/10/1/1, Anand Nagar Colony,Banjara Hills Hyderabad Hyderabad Tg 500004 In

Vendor Details

Country of origin: India

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Zestgab Plus Tablet

Zestgab Plus Tablet

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General Information

Contains

Marketer

Storage

Product introduction

Uses of Zestgab Plus Tablet

Benefits of Zestgab Plus Tablet

Side effects of Zestgab Plus Tablet

How to use Zestgab Plus Tablet

How Zestgab Plus Tablet works

Quick tips

Safety advice

Alcohol

Pregnancy

Breast feeding

Driving

Kidney

Liver

Fact Box

Habit Forming

Therapeutic Class

References

Want to know more

Have issue with the content

Disclaimer

Marketer details

Vendor Details

Lab tests offered by us

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