ZEROGRAIN-PLUS TABLET

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Primarily used for

Potentiallyunsafewith
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Alcohol
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Pregnancy
48.4
₹4.84/tablet
10 tablets in 1 strip
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Medicine Overview of ZEROGRAIN-PLUS TABLET

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Uses of Domperidone

Domperidone is used in the treatment of vomiting.
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Side effects of Domperidone

Common

Dry mouth.

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How to use Domperidone

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it.

How ZEROGRAIN-PLUS TABLET works

Domperidone indirectly stimulates the release of acetylcholine, a chemical messenger that can increase the motility of the intestine.
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Uses of Flunarizine

Flunarizine is used to prevent migraine.
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Side effects of Flunarizine

Common

Sleepiness, Weight gain, Muscle pain, Fatigue, Constipation, Nausea, Insomnia (difficulty in sleeping), Rhinitis.

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How to use Flunarizine

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it.

How ZEROGRAIN-PLUS TABLET works

Migraine headaches are thought to result from the dilatation of blood vessels in the head. Flunarizine works by preventing loss of tone and dilation of blood vessels, thus preventing the migraine headache.
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Uses of Paracetamol

Paracetamol is used in fever, headache, pain during menstruation, arthralgia, myalgia, dental pain and post operative pain.
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Side effects of Paracetamol

Common

Allergic reaction.

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How to use Paracetamol

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it.

How ZEROGRAIN-PLUS TABLET works

Paracetamol blocks the release of certain chemical messengers in the brain that is responsible for pain and fever.

In Depth Information on ZEROGRAIN-PLUS TABLET

Expert advice for Domperidone

  • Do not take Domperidone, if you are allergic to it or to any other content in the tablets.
  • Do not take the medicine, if you notice black, tarry stools (bowel motions) or blood in your stools, blockage or tear in the intestines or if you have a tumor of the pituitary gland (prolactinoma).
  • Do not take the drug, if you have moderate to severe liver disease, heart problems (irregular heart rate or heart failure) or abnormal salt levels in the blood.
  • Do not crush or chew the tablets, swallow them whole with a glass of water.
  • Do not take the drug if you intend to drive or operate heavy machinery as it may cause drowsiness.
  • Always take the tablets 15 to 30 minutes before meals and, if needed, before going to bed at night.
  • Consult your doctor, if you are above 60 years of age and taking domperidone for a long period of time.
  • Inform your doctor, if you are already taking medicines for fungal infections (ketoconazole) or antibiotics (e.g. gentamycin, erythromycin).

Expert advice for Flunarizine

  • Flunarizine should be taken at night-time before going to bed.
  • You may have to wait for 8 to 12 weeks to get the full effect.
  • Caution is advised in elderly patients, as it may cause depressive and extrapyramidal symptoms.
  • Do not take alcohol or sleep inducing medicine along with Flunarizine.
  • Flunarizine tablet contains lactose monohydrate. You should not take it if you have galactose intolerance, the Lapp lactase deficiency or glucose-galactose malabsorption.

Expert advice for Paracetamol

  • Paracetamol is a very safe and well-tolerated medicine for short term use.
  • Taking high dose of Paracetamol can cause serious liver damage.
  • Inform your doctor if you have a liver disease. Your dose may need to be adjusted.
  • Avoid excess intake of alcohol when taking Paracetamol, together they can affect your liver.
  • Immediately inform your doctor or contact a hospital emergency if you have taken an overdose of Paracetamol and you are feeling unwell.
Warnings
Special precautions for ZEROGRAIN-PLUS TABLET
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Alcohol
CAUTION
Zerograin-plus tablet may cause excessive drowsiness and calmness with alcohol.

Taking Paracetamol with alcohol can cause liver damage.
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Pregnancy
WEIGH RISKS VS BENEFITS
Zerograin-plus tablet may be unsafe to use during pregnancy.

Animal studies have shown adverse effects on the foetus, however, there are limited human studies. The benefits from use in pregnant women may be acceptable despite the risk. Please consult your doctor.
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Lactation
Unknown. Human and animal studies are not available. Please consult your doctor.
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Driving
CAUTION
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Kidney
CAUTION
Caution should be used in patients with severe renal impairment.

This medicine should be used with caution in patients with underlying kidney disease. Please Consult your doctor.
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Liver
CAUTION
Use of this medicine should be avoided in patients with underlying liver disease.

Patient Concerns

Frequently asked questions for ZEROGRAIN-PLUS TABLET

Frequently asked questions for Domperidone

Q. What is Domperidone used for?
Domperidone is used for the treatment of nausea (feeling sick) and vomiting as and when recommended by your doctor.
Q. Is domperidone an over the counter drug?
Domperidone is not an over the counter (OTC) medicine and it is not advisable to take it without a prescription.
Q. Does domperidone cause weight gain?
Weight gain has not been reported with the use of domperidone. If you notice any abnormal weight gain while using domperidone, please talk to your doctor.
Q. Does domperidone raise the blood pressure?
The increase in blood pressure is generally not seen with the use of domperidone. But if you experience an increase in blood pressure while using domperidone, please consult your doctor.
Q. Can I take domperidone for morning sickness?
Domperidone is not indicated or recommended for treating morning sickness. Please consult your doctor if you plan to take any medicine for treating morning sickness.
Q. How long can I take domperidone for breastfeeding?
Domperidone is not recommended if you are breastfeeding because it passes into breast milk and may affect your baby. Talk to your doctor as either you should not take this medicine or you should stop breastfeeding if you are asked to take it.
Q. Can I take domperidone with antibiotics?
The use of domperidone with antibiotics like erythromycin, levofloxacin, moxifloxacin, spiramycin, and some antifungals is not recommended. Please consult your doctor before using any antibiotics with domperidone.
Q. Can I take domperidone with lansoprazole?
Yes, domperidone can be taken with lansoprazole as no drug-drug interactions have been clinically seen when they are taken together. However, interactions may occur. Please consult your doctor before using the two medicines together.
Q. Can I take domperidone with doxycycline?
Yes, domperidone can be taken with doxycycline. No drug--drug interactions have been reported. However, please consult your doctor before taking domperidone with doxycycline.
Q. Can I take domperidone with omeprazole?
Yes, domperidone can be taken with omeprazole. No drug--drug interactions have been reported. However, interactions may occur. Please consult your doctor before using the two medicines together.
Q. Can I take domperidone with citalopram?
The use of domperidone with citalopram is not recommended as it may increase the underlying heart problems like prolonged QTc interval. Please consult your doctor before taking the two medicines together.
Q. Can I take domperidone with amitriptyline?
Yes, domperidone can be taken with amitriptyline. No drug--drug interactions have been reported. However, please consult your doctor before taking domperidone with amitriptyline.
Q. Can I take domperidone with amoxicillin?
Yes, domperidone can be taken with amoxicillin. No drug-drug interactions have been reported. However, please consult your doctor before taking domperidone with amoxicillin.
Q. Can I take domperidone with paracetamol?
Yes, domperidone can be taken with paracetamol. No drug--drug interactions have been reported. However, interactions may occur. Please consult your doctor.
Q. Can I take domperidone without food?
It is recommended to take domperidone tablets 15 - 30 minutes before meals.
Q. Can I take domperidone with tramadol?
Yes, domperidone can be taken with tramadol as no drug--drug interactions have been reported. However, please consult your doctor before taking domperidone with tramadol.
Q. Is domperidone safe in pregnancy?
There is limited data on the use of domperidone in pregnant women. Therefore, domperidone should only be used during pregnancy when justified and recommended by the doctor.
Q. Is domperidone safe?
Yes. Domperidone is safe if used at prescribed doses for the prescribed duration as advised by the physician/ doctor.
Q. Is domperidone safe for babies?
Yes, domperidone is safe for use babies if used at prescribed doses and duration as advised by your doctor. Please consult your doctor before giving any medicine to your child.
Q. Is domperidone used for motion sickness?
Domperidone is indicated for use in motion sickness. Please consult your doctor before using domperidone for motion sickness as it must be used in the dose and duration as advised by your doctor.
Q. Is domperidone an antibiotic?
No, domperidone is not an antibiotic. Domperidone is an anti-emetic which is used to treat nausea (feeling sick) and vomiting (being sick).
Q. Does domperidone cause drowsiness?
Drowsiness has been reported as one of the rare side effects with domperidone. Please talk to your doctor if you experience excessive drowsiness while taking domperidone.
Q. Does domperidone increase milk secretion?
Yes, domperidone can increase milk secretion also known as galactorrhea. This is an uncommon side effect of domperidone. Talk to your doctor if you are experiencing this side effect while taking this medicine.
Q. Does domperidone cause bloating (gas)?
Domperidone can cause some uncommon gastrointestinal side effects like regurgitation, appetite disorder, and heartburn, diarrhoea. However, bloating (gas) has not been reported as a side effect with domperidone.
Q. Does domperidone cause hair loss?
Domperidone has not been reported to cause hair loss. Please consult your doctor in case you experience excessive hair loss while taking domperidone.
Q. Does domperidone help constipation?
Domperidone is not indicated to treat constipation. Please talk to your doctor regarding its use.
Q. Does domperidone cause heart problems?
Domperidone may be associated with an increased risk of heartbeat problem and heart attack. This risk may be more likely in those over 60 years old or taking higher doses. The risk also increases when domperidone is given together with other medicines. Please share your medical history with your doctor if you are prescribed domperidone.
Q. Does domperidone cause constipation?
Yes, domperidone has been seen to cause constipation as a side effect.Consult your doctor if you experience excessive constipation while using domperidone.
Q. Does domperidone relieve bloating (gas)?
Domperidone is an anti-emetic which is used to treat nausea (feeling sick) and vomiting (being sick). It is not indicated to treat bloating (gas). Please consult your doctor before using this medicine.
Q. Can I take Domperidone with rabeprazole?
Domperidone can be safely taken with Rabeprazole as no harmful effects have been reported clinically. A fixed-dose combination of these two medicines is also available. Domperidone increases gut motility and Rabeprazole decreases the acid production in the stomach. So, this combination is very effective in the treatment of reflux esophagitis associated with acidity, heartburn, intestinal and stomach ulcers.
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Frequently asked questions for Flunarizine

Q. Is flunarizine safe?
Flunarizine is safe if used at prescribed doses for the prescribed duration as advised by the doctor.
Q. Is flunarizine safe in pregnancy?
There are no data on the use of flunarizine in pregnant women. It is hence advisable to avoid the use of flunarizine during pregnancy. Ask your doctor before taking flunarizine in pregnancy.
Q. What is flunarizine?
Flunarizine is a calcium channel blocker, and was initially used to improve blood flow. It was later used to treat dizziness and vertigo, and to prevent migraine.
Q. What is flunarizine used for?
Flunarizine is used to prevent migraine attacks. Migraine is a recurrent throbbing headache that typically affects one side of the head and is often accompanied by nausea and disturbed vision.
Q. Does flunarizine cause weight gain?
Flunarizine can cause weight gain. It is caused by an increase in appetite (feeling hungry) and can be avoided by keeping to your usual diet. Please consult your doctor if you experience weight gain after taking flunarizine.
Q. Does flunarizine work?
Flunarizine works if used at prescribed doses for the prescribed duration as advised by your doctor.
Q. How long does flunarizine take to work?
Flunarizine may start working at eight to twelve weeks. Always talk to your doctor before starting the medicine and for how long it needs to be taken. If the medicine works for you, keep taking the tablets for at least six months.
Q. How is Flunarizine different from Betahistine?
Betahistine is a histamine analog used to treat vertigo, tinnitus and hearing loss associated with Ménière's syndrome while Flunarizine is a calcium entry blocker used for preventing the attack of a migraine. However, Betahistine is also useful in the treatment of a migraine associated vertigo and $nmae is also useful in treating Meniere's diseases associated vertigo.
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Frequently asked questions for Paracetamol

Q. Can I take Paracetamol with vitamin B complex?
Yes, Paracetamol can be taken with vitamin B-complex preparations. They have been used together in the treatment of acute and painful diseases affecting nerves like trigeminal neuralgias, post-operative pain, etc. Paracetamol helps to relieve pain and vitamin B-complex corrects the deficiency that might be causing your symptoms.
Q. Is Paracetamol use associated with Helicobacter pylori infection?
No, Paracetamol use is not associated with Helicobacter pylori infection. Painkiller drugs can increase the acid secretion in the stomach, aggravate the symptoms of this infection and the risk of stomach and the intestine ulcer. However, this risk is minimum with paracetamol as compared to other pain killers.
Q. Can I take Paracetamol with fexofenadine?
Yes, Paracetamol can be taken safely with fexofenadine. No drug-drug interactions or any harmful effects have been reported. These are used together to treat the symptoms of cold, cough, flu or a sore-throat and other allergic or viral diseases. Fexofenadine helps to relieve sneezing, runny nose, itchy throat, or eyes and Paracetamol helps to relieve pain or fever.
Q. Can I take paracetamol with warfarin?
Paracetamol is safe to use occasionally with warfarin as other painkillers like ibuprofen and aspirin can increase the risk of bleeding. However, on a long-term use, paracetamol can also increase the risk of bleeding. Talk to your doctor before taking them together as you may need to be monitored regularly.
Q. Can I take paracetamol with tamsulosin?
Paracetamol can be taken with Tamsulosin. No harmful side effects or other interactions have been seen when they are taken together. Tamsulosin is an alpha adrenergic receptor blocker used to treat symptoms of benign prostatic hyperplasia.
Q. Can I take Paracetamol with cetirizine?
Yes, Paracetamol can be taken safely with cetirizine. No drug-drug interactions or any harmful effects have been reported. These are used together to treat the symptoms of cold, cough, flu or a sore throat and other allergic or viral diseases. Cetirizine helps to relieve sneezing, runny nose, itchy throat, or eyes and Paracetamol helps to relieve pain or fever.
Q. Can I take paracetamol with ibuprofen?
Yes, paracetamol can be taken with ibuprofen. Both help to relieve pain and fever and ibuprofen also decreases inflammation and swelling. However, both increase the acid secretion in the stomach and can cause acid reflux, heartburn, stomach, and intestinal ulcers and gut bleeding on long-term use.
Q. Does Paracetamol cause weight loss?
Paracetamol is not known to cause weight loss. It is a very safe medicine for short term use and can cause minor and rare side effects like low blood pressure, and allergic reactions.
Q. Can anyone be allergic to Paracetamol?
Yes, there have been reports of hypersensitivity and allergic reaction with the use of Paracetamol. Symptoms of an allergy include swelling of the face, mouth, and throat, shortness of breath, urticaria, red rash, and severe itching. Stop taking Paracetamol if you have such symptoms and immediately consult your doctor.
Q. How beneficial is to use Paracetamol with diclofenac?
Paracetamol and Diclofenac might be given together in case of fever and pain. Paracetamol has an early onset of action and it helps in relieving the symptoms till diclofenac starts working. However, both are pain killers and can affect stomach lining on long-term use leading to acid reflux, heartburn, and stomach ulcers and bleeding.
Q. Can I take paracetamol for stomach pain?
No, paracetamol should not be taken for stomach pain. You must consult your physician for this. The stomach pain must be due to some other underlying condition, which needs attention.
Q. Can I take paracetamol with aceclofenac?
Yes, Paracetamol can be given with aceclofenac for fever and pain. Paracetamol has an early onset of action and it helps in relieving the symptoms till Aceclofenac starts working. However, both are pain killers and can affect stomach lining on long-term use leading to acid reflux, heartburn, and stomach ulcers and bleeding.
Q. Does paracetamol treat sore-throat, flu or cold?
Paracetamol does not treat sore-throat, flu or cold but it can help in relieving fever and body aches associated with these conditions.
Q. Can I take paracetamol with codeine?
Paracetamol and codeine can be taken together. No drug-drug interactions or any harmful effects have been reported when they are used together. They are commonly given together for the relief of mild to moderate pain due to different reasons.
Q. Does paracetamol help a cough?
No, paracetamol does not help in the relief of cough but it can help in relieving associated fever and body aches.
Q. Why most cold or flu drugs contains paracetamol?
Paracetamol has both fever relieving and painkiller properties. Most people suffering from common cold or flu experience low-grade fever, muscle pain and overall feeling of tiredness. Paracetamol reduces these symptoms, so, it is commonly a part of cold or flu medicines.
Q. Does paracetamol contain alcohol?
No, paracetamol does not contain any alcohol.
Q. Can I take paracetamol with amoxicillin?
Paracetamol and amoxicillin can be taken together. Amoxicillin is an antibiotic and is used to treat bacterial infections. Paracetamol is given along, for the relief of any associated pain and fever. No drug-drug interactions or any harmful effects have been reported when they are used together.
Q. Does paracetamol have side effects?
Paracetamol is quite safe for short term use. It has side effects if taken in more than the dose advised and for a long-term. Immediately consult a doctor if there is nausea, stomach pain, loss of appetite, dark colored urine, clay colored stools or jaundice as it could be due to an overdose of paracetamol.
Q. Is paracetamol safe to use?
Paracetamol is safe to use in the dose as advised by the doctor. Use in more than recommended doses can do serious harm.
Q. Is it safe to take paracetamol with erythromycin?
Paracetamol and Erythromycin can be taken together. Erythromycin is an antibiotic and is used to treat bacterial infections. Paracetamol is given along, for the relief of associated fever. No drug-drug interactions or any harmful effects have been reported when they are used together.
Q. Is paracetamol an antibiotic?
Paracetamol is not an antibiotic. It's an analgesic (pain-killer) and antipyretic (for the relief of fever), whereas an antibiotic is useful for the treatment of infections.
Q. Can I take paracetamol with metronidazole?
Paracetamol and Metronidazole can be taken together. No drug-drug interactions or any harmful effects have been reported when used together.
Q. Can I take paracetamol with homeopathic medicine?
Ask your doctor before taking paracetamol with homeopathic medicine as there is no information available on this.
Q. Is it safe to take Paracetamol with Tramadol?
Yes, Paracetamol can be taken with Tramadol. They are used together for moderate to severe pain in various diseases and their use is associated with common side effects like nausea, dizziness, and sleepiness.No drug-drug interactions have been reported when they are used together.
Q. Can I take Paracetamol with Azithromycin?
Paracetamol and Azithromycin can be taken together. Azithromycin is an antibiotic and is used to treat bacterial infections. Paracetamol is given along, for the relief of any associated pain and fever. No drug-drug interactions or any harmful effects have been reported when they are used together.
Q. Can I take paracetamol for period pains?
Yes, Paracetamol is a pain killer and can help in the relief of mild to moderate pain associated with periods also known as dysmenorrhoea (painful menstruation).
Q. Is it safe to take Paracetamol with Naproxen?
Yes, paracetamol can be taken with Naproxen. Both are painkillers and belong to the group of non-steroidal anti-inflammatory drugs (NSAIDs) and are used to relieve pain and fever. However, long-term use affects the stomach lining and increase acid secretion which can lead to side effects like acid reflux, heartburn, stomach, and intestinal ulcers and bleeding.
Q. Can paracetamol make babies/ toddlers sleep when used for teething pain?
Paracetamol helps to relieve teething pain in infants and children but it does not make them sleep. The child may go to sleep once the pain is relieved.
Q. Can a patient with high blood pressure take paracetamol?
Occasional use of Paracetamol is safe in patients with high blood pressure. However, if it is to be taken for a long time, you must talk to your doctor. Paracetamol belongs to the group of painkillers called analgesics and antipyretics and these drugs can decrease the action of medicines taken by the patient for control of high blood pressure.
Q. Does Paracetamol interact with vitamin C?
Vitamin C can be taken with Paracetamol. However, vitamin C increases the blood levels of other drugs similar to Paracetamol, so it is advised to talk to your doctor if you have to take both these medicines for a long-term.
Q. What happens if you take an overdose of Paracetamol?
Overdose of Paracetamol can cause potentially life-threatening liver damage, which is the most serious side effect. Early symptoms may include nausea, vomiting, profuse sweating, and general tiredness. Kidney damage, decreased platelet count and coma may also occur. Immediately consult a doctor or consult an emergency in the case of suspected overdosage.
Q. What is the difference between Paracetamol and Ibuprofen?
Both Paracetamol and ibuprofen help to relieve mild to moderate pain and fever. Ibuprofen also helps to decrease redness and swelling because of the anti-inflammatory action while Paracetamol has no anti-inflammatory action. But the use of Paracetamol is much safer as it causes fewer side effects like stomach upset, ulcers, and bleeding than Ibuprofen.
Q. Can I take Paracetamol with hyoscine?
Yes, Paracetamol and hyoscine can be taken together. Hyoscine is used to relieve pain and cramps of the stomach, gut, urinary bladder and urinary tract while Paracetamol is used to relieve mild to moderate pain of a headache, toothache, muscle pain, joint pain, and fever. Together they can be advised by a doctor for painful conditions of the gut and urinary tract.
Q. Can I use Paracetamol after the caesarean section?
Yes, Paracetamol can be taken after a caesarean section to relieve pain. It is a very safe drug for pain relief and has minimal side effects at low doses. A very small amount of drug passes into breast milk that should not affect your baby. Paracetamol use also helps to lower the dose of other painkillers.
Q. Can I take Paracetamol with Betahistine?
Paracetamol can be taken with Betahistine. There are no reported drug-drug interactions or harmful effects when they are used together.
Q. Can I take Paracetamol with rabeprazole?
Paracetamol and Rabeprazole can be taken together. Rabeprazole is used to prevent paracetamol (painkillers) induced gastritis and stomach ulcers by decreasing the production of acid in the stomach. There are no clinically significant drug-drug interactions or harmful effects seen when they are used together.
Q. How much time does it take for Paracetamol to take effect?
Paracetamol usually starts to work within 30 minutes to 1 hour and the effect usually lasts for 4-6 hours. If you are not getting any relief in your pain or fever, consult your doctor as you may need a higher dose or some other medicine may need to be added.
Q. How is aspirin different from paracetamol?
Paracetamol helps to relieve mild to moderate pain and fever and has no effect on inflammation or swelling while Aspirin acts as a blood thinner in low doses and is helpful to prevent heart attacks and stroke and in higher doses, it relieves mild to moderate pain, fever, and inflammation.
Q. How beneficial is to take urofollitropin alpha with Paracetamol?
Urofollitropin alpha is given as a subcutaneous injection with the human chorionic gonadotropin (hCG) hormone to assist in ovulation and fertility. Urofollitropin alpha can cause abdominal or pelvic pain or pain and swelling at the injection site in some patients which can be relieved by taking Paracetamol.
Q. Can vitamin D be taken safely with Paracetamol?
Yes, vitamin D can be taken with Paracetamol. Patients with osteoarthritis who are on vitamin D and calcium may need to take Paracetamol for the relief of any associated pain. No drug-drug interactions or any harmful effects have been reported.
Q. Can I take clindamycin with Paracetamol?
Paracetamol and Clindamycin can be taken together. Clindamycin is an antibiotic and is used to treat bacterial infections. Paracetamol may be given along, for the relief of associated fever. No drug-drug interactions have been reported clinically. However, both are known to cause liver damage. Talk to your doctor if you need them for a long time.
Q. Does paracetamol affect the liver?
Use of paracetamol for a long time and above recommended doses can cause liver damage ranging from abnormal liver tests to liver failure. If you are taking paracetamol from a long time and have nausea, stomach pain, loss of appetite, dark colored urine, clay colored stools or jaundice, inform your doctor as these could be signs of an underlying liver damage.
Q. Can too much use of Paracetamol cause constipation?
Paracetamol is not known to cause constipation. Other common side effects of Paracetamol are rashes, low blood pressure, allergy. Patients who experience Paracetamol side effects should consult with a physician and stop taking the medication till then.
Q. Can I take Paracetamol if I have hepatitis?
Paracetamol is metabolized in the liver. Paracetamol is considered the safest painkiller to take for people with hepatitis for mild to moderate pain and fever. Consult your doctor before taking Paracetamol if you have hepatitis as it can cause liver damage if taken in higher doses or for a very long time.
Q. What are the serious side effects of taking excess Paracetamol?
Potentially severe life-threatening liver injury is a serious side effect seen with an overdose of Paracetamol. Overdose can also cause kidney injury, coma, and decreased platelet count. Early symptoms of an overdose include nausea, vomiting, and general tiredness. Immediately consult a doctor or reach an emergency in case of suspected overdose.
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