Xplocef Injection

Ceftriaxone (2000mg)+ Vancomycin (1000mg)

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required

Xplocef Injection is a combination medicine. It is prescribed to treat various types of bacterial infections. It fights against the microorganisms to prevent their growth and further spread of the infection.

Written By Dr. Anuj Saini, MMST, MBBS,
Reviewed By Dr. Mekhala Chandra, MD, MBBS,
Last updated on 10 Jan 2026 | 11:02 PM (IST)

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As per Ministry of Health and Family Welfare

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General Information

Contains

Ceftriaxone (2000mg)+ Vancomycin (1000mg)

Marketer

Elder Pharmaceuticals Ltd

Storage

Store below 30°C

The content is shown in English

Product introduction

Xplocef Injection should only be administered under the supervision of a healthcare professional. Do not miss any scheduled appointments for taking this medicine. The course of the treatment must be completed even if you feel better. Sudden discontinuation of the treatment may affect the potency of the medicine.

Some common side effects of this medicine are nausea, vomiting, diarrhea, indigestion, etc. If any of the side effects get aggravated, you must consult your doctor immediately. If you experience any allergic reaction (rashes, itching, swelling, shortness of breath, etc.), you must seek immediate medical help.

Before taking this medicine, you should tell your doctor if you are taking any medicines for any health condition. Pregnant or breastfeeding women should also consult with their doctor before taking it. Avoid drinking alcohol as it can cause excessive drowsiness with this medicine. It usually does not impair your ability to drive, but you should not drive if it makes you feel sleepy or dizzy. You must take adequate rest for a faster recovery, also take a healthy diet and drink plenty of water. Your doctor may ask for a few laboratory and diagnostic tests to know the effects of the medicine on your body.

Uses of Xplocef Injection

Bacterial infections

Benefits of Xplocef Injection

Bacterial infections
Xplocef Injection works by killing bacteria which can cause bacterial infections. It is used to treat many different types of bacterial infections. It is given by a doctor or nurse into a vein and should not be self-administered. Xplocef Injection usually makes you feel better very quickly but you should continue taking it as prescribed even when you feel better to make sure that all bacteria are killed and do not become resistant.

Side effects of Xplocef Injection

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Xplocef

Breathlessness
Rash
Decreased blood pressure
Increased liver enzymes
Allergic reaction
Erythema (skin redness)
Itching
Diarrhea

How to use Xplocef Injection

Your doctor or nurse will give you this medicine. Kindly do not self administer.

How Xplocef Injection works

Xplocef Injection is a combination of two medicines: Ceftriaxone and Vancomycin. They work by preventing the formation of the bacterial protective covering which is essential for the survival of bacteria in the human body. Together, they eradicate your infection effectively.

Quick tips

Xplocef Injection is given as an injection under the supervision of a doctor.
Do not skip any dose and finish the course as suggested by the doctor.
It is advisable to stay hydrated and drink plenty of water to overcome medicine side effects.
Use caution while driving or doing anything that requires concentration as Xplocef Injection can cause drowsiness and sleepiness.
Inform your doctor if you experience rashes, itching, swelling and shortness of breath while taking the medicine.
You will be monitored for blood pressure and liver function during the treatment with this medicine.

Safety advice

Alcohol

SAFE

Consuming alcohol with Xplocef Injection does not usually cause any harmful side effects.

Pregnancy

CONSULT YOUR DOCTOR

The safety of Xplocef Injection during pregnancy has not been established. There are no adequate and well-controlled studies in pregnant women, and animal data on reproductive toxicity are insufficient. Your doctor will weigh the benefits and any potential risks before prescribing.

Breast feeding

SAFE IF PRESCRIBED

Xplocef Injection may be safe to use during breastfeeding. Animal studies have shown low or no adverse effects to the developing baby; however, there are limited human studies.

Driving

UNSAFE

Xplocef Injection may decrease alertness, affect your vision, or make you feel sleepy and dizzy. Do not drive if these symptoms occur.

Kidney

CAUTION

Xplocef Injection should be used with caution in patients with kidney disease. Dose adjustment may be needed.
Regular monitoring of kidney function test and some blood tests is advised while you are taking this medicine.

Liver

CAUTION

Xplocef Injection should be used with caution in patients with severe liver disease. Dose adjustment may be needed.
Dose adjustment of Xplocef Injection is not recommended in patients with mild to moderate liver disease.

Frequently asked questions

How long does Xplocef Injection take to work?

Usually, Xplocef Injection starts working soon after taking it. However, it may take some days to kill all the harmful bacteria and make you feel better.

For how long is Xplocef Injection used?

Duration of treatment with Xplocef Injection depends on the severity of your infection, which will be decided by your doctor.

Fact Box

Habit Forming

Therapeutic Class

ANTI INFECTIVES

Related lab tests

Complete Blood Count

Peripheral Smear Examination

References

Chaudhary M, Shrivastava SM, Sehgal R. Efficacy and safety study of fixed-dose combination of ceftriaxone-vancomycin injection in patients with various infections. Curr Drug Saf. 2008 Jan;3(1):82-5. [Accessed 10 Jan. 2026]. Available from:

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Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: Elder Pharmaceuticals Ltd
Address: “Elder House” Plot No. C-9, Dalia Industrial Estate, Off Veera Desai Road, Andheri (W), Mumbai – 400053.

Vendor Details

Country of origin: India

Lab tests offered by us

Why we need a prescription?