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Wakelix 4.45 Tablet 1
Wakelix 4.45 Tablet 2
Wakelix 4.45 Tablet 3
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Wakelix 4.45 Tablet 5
Wakelix 4.45 Tablet 6
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Wakelix 4.45 Tablet

Pitolisant (4.45mg)
Genuine
Authenticity Assured
Prescription
required

Product Summary :

Wakelix 4.45 Tablet is a psychostimulant that is used to treat excessive daytime sleepiness or cataplexy in people aged 6 years and older. It acts on H3 receptors to increase histamine activity in the brain and help reduce symptoms of narcolepsy. It is usually taken once daily in the morning upon waking. Some common side effects in adults may include insomnia, nausea, and anxiety. Wakelix 4.45 Tablet must not be used in people with severe liver disease.
 


Written By Dr. Nikita Saini, MBA, MDS,
Reviewed By Dr. Dheeraj Kumar Sharma, PhD, M.Pharm,
Last updated on 12 Oct 2026 | 01:03 AM (IST)
₹175 MRP ₹1908% off 
(Inclusive of applicable taxes)
 
 
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Wakelix 4.45 Tablet 1
Wakelix 4.45 Tablet 2
Wakelix 4.45 Tablet 3
Wakelix 4.45 Tablet 4
Wakelix 4.45 Tablet 5
Wakelix 4.45 Tablet 6

Product introduction

Wakelix 4.45 Tablet is used to treat excessive daytime sleepiness and cataplexy in people of age 6 years and above with narcolepsy. It works by increasing histamine activity in the brain that helps improve wakefulness.


Wakelix 4.45 Tablet should be taken exactly as prescribed by the doctor. It is taken once daily in the morning upon waking. Your doctor may increase your dose gradually depending on the response and tolerability. If you ever miss a dose, take the next dose the following morning rather than taking an extra dose.


The most common side effects in adults may include insomnia, nausea, and anxiety. However, in children, the most common side effects may include headache and insomnia. 


Wakelix 4.45 Tablet should not be used in people with known hypersensitivity to pitolisant and in people with severe liver diseases. Always tell your doctor about all medicines you are taking before starting treatment.


 

Uses of Wakelix Tablet

  • Treatment of Narcolepsy (Uncontrollable daytime sleepiness)

Benefits of Wakelix Tablet

Treatment of Narcolepsy (Uncontrollable daytime sleepiness)
Wakelix 4.45 Tablet helps in the management of excessive daytime sleepiness or cataplexy associated with narcolepsy in patients who are 6 years and older. It can help reduce episodes of EDS, reduce the chances of disrupted sleep, and improve sleep quality.

Side effects of Wakelix Tablet

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Wakelix
  • Insomnia (difficulty in sleeping)
  • Nausea
  • Anxiety
  • Headache

How to use Wakelix Tablet

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Wakelix 4.45 Tablet may be taken with or without food.

How Wakelix Tablet works

Wakelix 4.45 Tablet acts on H3 receptors and increases histamine activity in the brain. Its exact mechanism in treating excessive daytime sleepiness and cataplexy associated with narcolepsy is not known.

Dosage

The dose of Wakelix 4.45 Tablet depends on the patient's age, response to treatment, tolerability, kidney and liver function, and other medicines being taken. In adults, it is generally started at a lower dose and gradually increased as advised by the doctor. Wakelix 4.45 Tablet is taken by mouth once daily in the morning upon waking.


 

Quick tips

  • Wakelix 4.45 Tablet is usually taken once daily in the morning upon waking or exactly as advised by the doctor.
  • Do not take an extra dose if you miss a dose. Take the next dose the following morning.
  • Inform your doctor about all medicines you take, particularly medicines that can affect the QT interval.
  • Tell your doctor if you have kidney or liver disease, as dose adjustment or additional monitoring may be required.
  • Wakelix 4.45 Tablet may reduce the effectiveness of hormonal contraceptives. Use an alternative non-hormonal contraceptive method during treatment and for at least 21 days after stopping the medicine.
  • Consult your doctor before using Wakelix 4.45 Tablet while you are pregnant or breastfeeding.

Safety advice

Alcohol

Alcohol

CONSULT YOUR DOCTOR
It is not known whether it is safe to consume alcohol with Wakelix 4.45 Tablet. Please consult your doctor.
Pregnancy

Pregnancy

CONSULT YOUR DOCTOR
The safety of Wakelix 4.45 Tablet during pregnancy has not been established. There are no adequate and well-controlled studies in pregnant women, and animal data on reproductive toxicity are insufficient. Your doctor will weigh the benefits and any potential risks before prescribing.
Breast feeding

Breast feeding

CONSULT YOUR DOCTOR
Information regarding the use of Wakelix 4.45 Tablet during breastfeeding is not available. Please consult your doctor.
Driving

Driving

CONSULT YOUR DOCTOR
It is not known whether Wakelix 4.45 Tablet alters the ability to drive. Do not drive if you experience any symptoms that affect your ability to concentrate and react. Please consult your doctor.
Kidney

Kidney

CAUTION
Wakelix 4.45 Tablet should be used with caution in patients with kidney disease. Dose adjustment may be needed.
Liver

Liver

CAUTION
Wakelix 4.45 Tablet should be used with caution in patients with severe liver disease. Dose adjustment may be needed.
All

Frequently asked questions

Wakelix 4.45 Tablet is used to treat excessive daytime sleepiness and cataplexy in people aged 6 years and older with narcolepsy and helps improve wakefulness, improve muscle fatigue caused by sudden triggering of emotions, and reduce the episodes of sleep paralysis.
Wakelix 4.45 Tablet acts as an antagonist/inverse agonist at histamine-3 (H3) receptors, which increases brain histamine signaling and helps maintain wakefulness. Its exact mechanism in treating narcolepsy symptoms is not known.
Wakelix 4.45 Tablet is taken by mouth once daily in the morning when you wake up. Your doctor may gradually increase the dose based on your response and tolerability.
If you miss a dose, take your next dose the following morning upon waking. Do not take an extra dose to make up for the missed dose.
The most common side effects in adults may include insomnia, nausea, and anxiety. Whereas in younger patients (6 years and above), it may cause headache and insomnia.
Wakelix 4.45 Tablet may affect the heart's electrical activity and increase the risk of abnormal heart rhythms. It should be avoided in people with certain heart rhythm problems or those taking medicines that can cause similar effects. Extra caution may be needed in people at higher risk of abnormal heart rhythms.
Yes. Wakelix 4.45 Tablet may reduce the effectiveness of hormonal contraceptives. People using hormonal contraception should use an alternative non-hormonal contraceptive method during treatment and for at least 21 days after stopping Wakelix 4.45 Tablet.
Dose adjustment may be required when kidney function is reduced. Wakelix 4.45 Tablet is not recommended in patients with end-stage renal disease. Consult your doctor before using it if you have kidney disease.
Wakelix 4.45 Tablet is contraindicated in severe hepatic impairment. Dose adjustment is recommended in moderate hepatic impairment, while patients with mild hepatic impairment should be monitored.

Fact Box

Chemical Class

Piperidine-based ether derivatives

Habit Forming

No

Therapeutic Class

NEURO CNS

Action Class

Histamine H₃ Receptor Antagonists and Inverse Agonists
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Disclaimer

Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Manufacturer details

Name: A)MSN Laboratories Private Limited
Address: A)Formulation Division, Unit-04, Sy. No's. (Parts of) 884, 885, 929, 930, 932, 933, 935, 937-941 & 951.Mekaguda (Village), Nandigama (Mandal), Ranga Reddy (District), Pin Code - 509 228, Telangana, India.

Marketer details

Name: MSN Laboratories Private Limited
Address: Formulation Division, Unit-04, Sy. No's. (Parts of) 884, 885, 929, 930, 932, 933, 935, 937-941 & 951.Mekaguda (Village), Nandigama (Mandal), Ranga Reddy (District), Pin Code - 509 228, Telangana, India.

Vendor Details

Country of origin: India
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