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Varnisam 0.5 Tablet

Varenicline (0.5mg)
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Varnisam 0.5 Tablet helps quit smoking by reducing the craving for a cigarette and the irritable feeling that occurs when you stop smoking. It works by blocking the nicotine effect on the brain and this suppresses enjoyment while smoking or the urge to smoke.

Written By Dr. Subita Alagh, BDS,
Reviewed By Dr. Rajeev Sharma, MBA, MBBS,
Last updated on 08 Jan 2026 | 04:19 PM (IST)
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General Information

The content is shown in English
Varnisam 0.5 Tablet image
Varnisam 0.5 Tablet image
Varnisam 0.5 Tablet image
Varnisam 0.5 Tablet image

Product introduction

Varnisam 0.5 Tablet may be taken with or without food, preferably at the same time each day. Take it in the dose and duration as advised by your doctor. If you have missed a dose, take it as soon as you remember. Do not skip any doses and finish the full course of treatment. You should never stop this medicine suddenly without talking to your doctor. This medication mustn't be stopped suddenly without talking to your doctor.

Some common side effects of using this medication are nausea, headache, insomnia (difficulty sleeping), abnormal dreams, and nasopharyngitis (inflammation of the throat and nasal passages). Initially, it may also cause dizziness and sleepiness, so do not drive or do anything that requires mental focus until you know how this medicine affects you.

Before taking Varnisam 0.5 Tablet, inform your doctor if you have a history of heart diseases, fits (seizures), or other mental disorders. Remember it will take time, support, willpower, and determination to quit the habit of smoking. It should be used as a smoking cessation aid along with programs including education, counseling, and support. Quitting smoking reduces the risk of developing further health-related problems such as heart or lung diseases as well as certain types of cancer.

Uses of Varnisam Tablet

  • Quitting smoking

Benefits of Varnisam Tablet

Quitting smoking
Varnisam 0.5 Tablet is a medicine used, along with social support and counseling, to help people quit smoking and to prevent an urge to smoke again. Varnisam 0.5 Tablet starts working from the very first dose and is a very safe and effective way of treating smoking addiction.

Side effects of Varnisam Tablet

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Varnisam
  • Nausea
  • Headache
  • Insomnia (difficulty in sleeping)
  • Abnormal dreams
  • Nasopharyngitis (inflammation of the throat and nasal passages)

How to use Varnisam Tablet

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Varnisam 0.5 Tablet may be taken with or without food.

How Varnisam Tablet works

Varnisam 0.5 Tablet is a smoking cessation aid. It works by mimicking the effect of nicotine by binding to the nicotine receptors in the brain. This reduces the urge to smoke, relieves withdrawal symptoms, and helps you quit smoking.

Quick tips

  • Varnisam 0.5 Tablet helps you to quit smoking by reducing the craving for a cigarette and the irritable feeling that occurs when you stop smoking.
  • In addition, counselling should be done to increase the chances of a successful quit attempt.
  • Quitting smoking can lower your chances of having lung disease, heart disease or getting certain types of cancer that are related to smoking.
  • Varnisam 0.5 Tablet can make you very sleepy. Don't drive or do anything requiring concentration until you know how it affects you.
  • Stop taking Varnisam 0.5 Tablet and inform your doctor if you notice sudden mood and behavior changes or develop suicidal thoughts.
  • Inform your doctor if you have a history of heart diseases, fits (seizures), or other mental disorders.
  • Varnisam 0.5 Tablet helps you to quit smoking by reducing the craving for a cigarette and the irritable feeling that occurs when you stop smoking.
  • In addition, counselling should be done to increase the chances of a successful quit attempt.
  • Quitting smoking can lower your chances of having lung disease, heart disease or getting certain types of cancer that are related to smoking.
  • Varnisam 0.5 Tablet can make you very sleepy. Don't drive or do anything requiring concentration until you know how it affects you.
  • Stop taking Varnisam 0.5 Tablet and inform your doctor if you notice sudden mood and behavior changes or develop suicidal thoughts.
  • Inform your doctor if you have a history of heart diseases, fits (seizures), or other mental disorders.

Safety advice

Alcohol

Alcohol

UNSAFE
It is unsafe to consume alcohol with Varnisam 0.5 Tablet
Pregnancy

Pregnancy

CONSULT YOUR DOCTOR
The safety of Varnisam 0.5 Tablet during pregnancy has not been established. There are no adequate and well-controlled studies in pregnant women, and animal data on reproductive toxicity are insufficient. Your doctor will weigh the benefits and any potential risks before prescribing.
Breast feeding

Breast feeding

CAUTION
Varnisam 0.5 Tablet should be used with caution during breastfeeding. Breastfeeding should be held until the treatment of the mother is completed and the drug is eliminated from the body.
Driving

Driving

UNSAFE
Varnisam 0.5 Tablet may decrease alertness, affect your vision, or make you feel sleepy and dizzy. Do not drive if these symptoms occur.
Kidney

Kidney

CAUTION
Varnisam 0.5 Tablet should be used with caution in patients with kidney disease. Dose adjustment may be needed.
Liver

Liver

SAFE IF PRESCRIBED
Varnisam 0.5 Tablet is safe to use in patients with liver disease. No dose adjustment is recommended.

Interaction with drugs

Taking Varnisam with any of the following medicines can modify the effect of either of them and cause some undesirable side effects
Mild

Ranolazine (Oral Route)

Your doctor may monitor the treatment outcome and may modify the treatment protocol as per the observation.

Frequently asked questions

No, Varnisam 0.5 Tablet is not an anti-depressant medicine. It belongs to a class of medicines known as smoking cessation aids. It does not contain any nicotine. It blocks the action of nicotine in your brain and helps to reduce cravings. It also helps with the withdrawal symptoms associated with giving up smoking. Quitting smoking feels like a loss as people associate smoking with pleasure but Varnisam 0.5 Tablet is not an antidepressant.
You can take Varnisam 0.5 Tablet at any time of the day. However, it is advised to take the medicine at the same time each day so that you remember taking it. Initially, it is prescribed once daily and then twice, morning and evening. Take it exactly as prescribed by your doctor. Check with your doctor if you are not sure or if you have any queries.
Yes, Varnisam 0.5 Tablet may cause sleepiness. It may also cause dizziness, trouble in concentrating, and transient loss of consciousness. You should avoid driving, operating complex machinery, or engaging in any potentially hazardous activity until and unless you know how this medicine affects you.
If you really want to quit smoking you should continue taking Varnisam 0.5 Tablet as advised by your doctor. However, if you experience serious side effects or if you are not sure consult your doctor. Sudden discontinuation of Varnisam 0.5 Tablet in some cases have resulted in irritability and sleep disturbances. In such cases, gradual tapering of Varnisam 0.5 Tablet is recommended.
Yes, you can take both together for better results, as they do not interfere with working of each other. However, taking these medicines together is not recommended since there are increased chances of side effects, which might force you to stop all treatment together. The side effects include nausea, vomiting, headache, dizziness, upset stomach, and tiredness.
Take it as prescribed by your doctor. Take it after a meal with a full glass of water. Swallow the medicine without breaking or crushing. There are 3 ways which can help you quit with Varnisam 0.5 Tablet. Firstly, choosing a quit date when you will stop smoking and start taking Varnisam 0.5 Tablet 1 week prior to that date. Secondly, take Varnisam 0.5 Tablet for 12 weeks. Pick a date to quit smoking between days 8 and 35 of treatment and take it for 12 weeks. Lastly, if you are sure that you are not able or willing to quit smoking right away, start taking Varnisam 0.5 Tablet and reduce smoking during the first 12 weeks of treatment. Aim to quit smoking by the end of 12 week. An additional 12 weeks of treatment is recommended for successful quitters to increase the likelihood of complete cessation of smoking.
If you really want to quit smoking, it is best to first decide on a quit date and stick to it. Initially the process to quit smoking may seem very difficult. However, for the first 1-2 weeks you can continue smoking. Continuing to smoke after your ‘quit date’ is not dangerous but will mean that you are less likely to quit successfully. Varnisam 0.5 Tablet may help you in the process as it reduces the effect of cigarettes if you do smoke when on treatment.
Speak to your doctor about whether another course of Varnisam 0.5 Tablet will be right for you. Another course can only be started if you are motivated to quit smoking and were not able to do so during prior Varnisam 0.5 Tablet treatment for reasons other than side effects or you returned to smoking after quitting.

Fact Box

Chemical Class

Pyridazine derivative

Habit Forming

No

Therapeutic Class

NEURO CNS

Action Class

Nicotinic Receptor Partial Agonist

References

  1. Stahl SM, editor. Varenicline. In: Stahl's Essential Pschopharmacology: Prescriber's Guide. 5th ed. New York, New York: Cambridge University Press; 2014. pp. 717-19.
  2. Lüscher C. Drugs of Abuse. In: Katzung BG, Masters SB, Trevor AJ, editors. Basic and Clinical Pharmacology. 11th ed. New Delhi, India: Tata McGraw Hill Education Private Limited; 2009. p. 562.
  3. Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. p. 1461.
  4. Varenicline tartrate. Sandwich, Kent: Pfizer Limited; 2006 [revised Aug. 2018]. [Accessed 28 Jan. 2019] (online) Available from:
  5. Varenicline. New York, New York: Pfizer Labs; 2006 [revised Oct. 2014]. [Accessed 19 Mar. 2019] (online) Available from:
  6. Drugs and Lactation Database (LactMed) [Internet]. Bethesda (MD): National Library of Medicine (US); 2006. Varenicline. [Updated 2018 Dec 3]. [Accessed 20 Feb. 2020] (online) Available from:
  7. Central Drugs Standard Control Organisation (CDSCO). [Accessed 19 Mar. 2019] (online) Available from:
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Disclaimer

Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: Origin Health Care Pvt Ltd
Address: H.No.16-310/6/1/1Asaleem Nagar, Musharambagh, Hyderabad-2, Telangana

Vendor Details

Country of origin: India
A licensed vendor partner from your nearest location will deliver Varnisam 0.5 Tablet. Once the pharmacy accepts your order, the details of the pharmacy will be shared with you. Acceptance of your order is based on the validity of your doctor's ℞ and the availability of this medicine.

In case of any issues, contact us

Email ID: [email protected]
Phone Number: 0124-4166666
Address: 5th Floor Tower - B of the Presidency Building, 46/4 Mehrauli Gurgaon Road, Sector 14, Gurugram, Haryana-122001, India
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