Vanguard DAPP L4 Injection

Canine Leptospirosis Vaccine (NA)+ Combined Canine Distemper, Adenovirus Type 2, Parvovirus, Parainfluenza Virus Vaccine (NA)

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Animal use

not for humans

Prescription

required

Cold stored

Stored between 2-8°C

Vanguard DAPP L4 Injection is used for the active immunization of puppies and dogs against several serious infectious diseases. It helps protect against canine distemper, infectious canine hepatitis, canine parvovirus enteritis, respiratory disease associated with canine parainfluenza virus, and leptospirosis.

Written By Dr. Sakshi Jain, MS, BDS,
Reviewed By Dr. Rajeev Sharma, MBA, MBBS,
Last updated on 27 Aug 2026 | 01:03 AM (IST)

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General Information

Contains

Canine Leptospirosis Vaccine (NA)+ Combined Canine Distemper, Adenovirus Type 2, Parvovirus, Parainfluenza Virus Vaccine (NA)

Marketer

Zoetis India Limited

Storage

Store in a refrigerator (2 - 8°C). Do not freeze.

The content is shown in English

Your pet's medicine at a glance

Vanguard DAPP L4 Injection should be administered only by, or under the guidance of, a veterinarian according to the recommended vaccination schedule. Only healthy animals should be vaccinated. Dogs should be treated for internal and external parasites at least 10 days before vaccination. Avoid exposing the dog to potentially infected environments for about 21 days after vaccination to allow adequate immunity to develop.

There is limited data on the common side effects of Vanguard DAPP L4 Injection. However, some animals may develop mild hypersensitivity reactions after vaccination. Monitor the dog after vaccination for symptoms such as swelling, breathing difficulty, weakness, vomiting, or unusual discomfort and seek veterinary attention if these occur.

Vaccination of pregnant or lactating dogs is not recommended. Let your veterinarian know about any other medicines your dog is given, as they may interfere with the immune response. Dogs that are stressed, malnourished, suffering from parasite infestations, or incubating infectious diseases may not develop adequate protection after vaccination.

Uses of Vanguard DAPP L4 Injection in pets

Prevention of Canine Distemper
Prevention of Infectious Canine Hepatitis
Prevention of Canine Parvovirus
Prevention of Respiratory Disease
Prevention of Leptospirosis

Benefits of Vanguard DAPP L4 Injection for your pet

Prevention of Canine Distemper
Vanguard DAPP L4 Injection helps protect dogs against canine distemper, a highly contagious viral disease that can affect the respiratory, digestive, and nervous systems. Vaccination helps the immune system recognize and fight the virus. This reduces the risk of severe symptoms such as fever, coughing, vomiting, diarrhea, seizures, and neurological complications. This vaccine also helps lower the chances of serious illness and long-term health effects associated with distemper infection.

Prevention of Infectious Canine Hepatitis
Vanguard DAPP L4 Injection helps protect dogs against infectious canine hepatitis caused by canine adenovirus. This disease can damage important organs such as the liver, kidneys, and blood vessels, and may lead to symptoms like fever, abdominal pain, vomiting, and bleeding problems. The vaccine helps build immunity against the virus and may reduce the severity and complications of infection.

Prevention of Canine Parvovirus
Vanguard DAPP L4 Injection helps prevent canine parvovirus disease, a severe viral infection that commonly affects puppies and young dogs. The disease mainly attacks the digestive system and can cause severe vomiting, bloody diarrhea, dehydration, weakness, and loss of appetite. Vaccination helps the body develop protection against the virus, thereby reducing the risk of serious gastrointestinal illness and complications related to dehydration and infection.

Prevention of Respiratory Disease
Vanguard DAPP L4 Injection helps protect dogs against respiratory disease associated with canine parainfluenza virus and canine adenovirus type 2. These infections are commonly linked with kennel cough and may cause coughing, sneezing, nasal discharge, fever, and breathing discomfort. Vaccination helps strengthen the dog’s immune response against these respiratory pathogens and may help reduce the severity and spread of infection, especially in dogs exposed to crowded environments.

Prevention of Leptospirosis
Leptospirosis is a bacterial infection that can affect the kidneys, liver, and other organs, and may lead to fever, vomiting, weakness, dehydration, and loss of appetite. Vanguard DAPP L4 Injection helps protect dogs against leptospirosis caused by Leptospira canicola and Leptospira icterohaemorrhagiae. Vaccination helps the immune system develop protection against these bacteria, thereby helping reduce the risk of severe illness and organ-related complications.

Side effects of Vanguard DAPP L4 Injection in pets

Vanguard DAPP L4 Injection does not pose serious side effects and is well-tolerated by pets. In case the side effects do occur, they're likely to subside once the body adapts to the medicine. Consult your pet's veterinarian if these side effects persist or bother your pet. The most common side effects include-

Common side effects of Vanguard

Limited data available

How can I give Vanguard DAPP L4 Injection to my pet?

Your doctor or nurse will give you this medicine. Kindly do not self administer.

How Vanguard Vaccine works

Vanguard DAPP L4 Injection contains modified live strains of canine distemper virus, canine adenovirus type 2, canine parvovirus, and canine parainfluenza virus, along with inactivated Leptospira components. After vaccination, these weakened or inactivated organisms stimulate the dog’s immune system to produce protective antibodies and immune memory without causing the actual disease. This helps the body recognize and respond more effectively to future exposure to these infectious agents, thereby reducing the risk and severity of infection.

Quick tips

Make sure your dog is healthy before vaccination. Inform the veterinarian if your dog has a fever, weakness, vomiting, diarrhea, or any ongoing illness before receiving Vanguard DAPP L4 Injection.
Deworm and treat your dog for external parasites at least 10 days before vaccination, as parasite infestations may affect the immune response to the vaccine.
Avoid exposing your dog to crowded parks, kennels, or potentially infected animals for about 21 days after vaccination to allow proper immunity to develop.
Monitor your dog for any unusual reactions after vaccination, such as swelling, breathing difficulty, weakness, or persistent discomfort, and contact the veterinarian immediately if these occur.
Inform the veterinarian about any ongoing medicines, especially corticosteroids or antiviral drugs, as these may interfere with the vaccine response.

Safety advice

Pregnancy

Vaccination of pregnant dogs is not recommended. Inform the veterinarian if the dog is pregnant before vaccination so that appropriate advice can be provided.

Breast feeding

Vaccination of lactating dogs is not recommended. Consult the veterinarian before administering the vaccine to nursing dogs.

Kidney

There is limited data available regarding the use of Vanguard DAPP L4 Injection in animals with kidney disease. It is generally recommended to vaccinate only healthy animals, so dogs with kidney disease should be assessed by a veterinarian before vaccination.

Liver

There is limited data available regarding the use of Vanguard DAPP L4 Injection in animals with liver disease. It is generally recommended to vaccinate only healthy animals. Dogs with liver disease should be evaluated by a veterinarian to determine suitability before administration.

Frequently asked questions

What is Vanguard DAPP L4 Injection used for?

Vanguard DAPP L4 Injection is used to immunize puppies and dogs against several serious infectious diseases. It helps protect against canine distemper, infectious canine hepatitis, canine parvovirus enteritis, respiratory disease associated with canine parainfluenza virus, and leptospirosis caused by Leptospira canicola and Leptospira icterohaemorrhagiae.

At what age can puppies receive Vanguard DAPP L4 Injection?

Puppies can generally be vaccinated from 8 weeks of age with one dose of Vanguard DAPP L4 Injection, followed by a second dose about 3 weeks later. In high-risk situations, vaccination against certain diseases may begin from 6 weeks of age as advised by the veterinarian. The vaccination schedule may vary depending on the puppy’s health status and exposure risk.

Can sick dogs receive Vanguard DAPP L4 Injection?

Only healthy dogs should receive Vanguard DAPP L4 Injection. Dogs that are stressed, malnourished, affected by parasite infestations, or incubating infectious diseases may not develop an adequate immune response after vaccination.

Are there any side effects associated with Vanguard DAPP L4 Injection?

Some dogs may occasionally develop mild hypersensitivity reactions after vaccination. In rare cases, severe allergic reactions such as anaphylactic shock may occur and require immediate veterinary treatment. Contact the veterinarian immediately if the dog develops breathing difficulty, swelling, weakness, or unusual symptoms after vaccination.

Does my dog need booster vaccinations after the initial doses?

Yes, annual revaccination with a single dose of Vanguard DAPP L4 Injection is recommended to help maintain protection against infectious diseases. Booster vaccination plays an important role in supporting long-term immunity. Your veterinarian will advise the most appropriate vaccination schedule for your dog.

Can Vanguard DAPP L4 Injection be given during pregnancy or lactation?

Vaccination of pregnant or lactating dogs is not recommended. Inform the veterinarian if the dog is pregnant or nursing before vaccination. The veterinarian will decide the most appropriate course of action based on the animal’s condition.

What precautions should be followed after vaccination?

Dogs should be protected from potential exposure to infection for about 21 days after vaccination to allow immunity to develop properly. It is also recommended that dogs be treated for internal and external parasites before vaccination. Continue routine veterinary care and follow the vaccination schedule advised by the veterinarian.

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Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: Zoetis India Limited
Address: Godown No. 1 & 2, Bldg. No 12B, Prithvi Complex, Reti Bunder Road, Kalbar, Tah Bhiwandi -421302, Dist. Thane

Importer details

Name: Zoetis India Limited
Address: Godown No. 1 & 2, Bldg. No 12B, Prithvi Complex, Reti Bunder Road, Kalbar, Tah Bhiwandi-421302, Dist. Thane

Vendor Details

Country of origin: United states

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Vanguard DAPP L4 Injection

Vanguard DAPP L4 Injection

Save more with additional offers

General Information

Contains

Marketer

Storage

Your pet's medicine at a glance

Uses of Vanguard DAPP L4 Injection in pets

Benefits of Vanguard DAPP L4 Injection for your pet

Side effects of Vanguard DAPP L4 Injection in pets

How can I give Vanguard DAPP L4 Injection to my pet?

How Vanguard Vaccine works

Quick tips

Safety advice

Pregnancy

Breast feeding

Kidney

Liver

Frequently asked questions

What is Vanguard DAPP L4 Injection used for?

At what age can puppies receive Vanguard DAPP L4 Injection?

Can sick dogs receive Vanguard DAPP L4 Injection?

Are there any side effects associated with Vanguard DAPP L4 Injection?

Does my dog need booster vaccinations after the initial doses?

Can Vanguard DAPP L4 Injection be given during pregnancy or lactation?

What precautions should be followed after vaccination?

Fact Box

Habit Forming

Therapeutic Class

References

Want to know more

Have issue with the content

Disclaimer

Marketer details

Importer details

Vendor Details

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