Upcyte PGN Tablet

Pregabalin (75mg)+ Nortriptyline (10mg)+ Methylcobalamin (1500mcg)+ Vitamin D3 (2000IU)

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Upcyte PGN Tablet is a combination medicine used for the treatment of neuropathic pain. This medicine decreases pain by controlling the calcium channel activity of the nerve cells and increases the level of chemical messengers in the brain that help regulate mood and protect nerve fibers.

Written By Dr. Subita Alagh, BDS,
Reviewed By Dr. Rajeev Sharma, MBA, MBBS,
Last updated on 25 Nov 2025 | 03:07 PM (IST)

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General Information

Contains

Pregabalin (75mg)+ Nortriptyline (10mg)+ Methylcobalamin (1500mcg)+ Vitamin D3 (2000IU)

Marketer

Medicyte Pharmaceuticals Pvt Ltd

Storage

Store below 30°C

The content is shown in English

Product introduction

Upcyte PGN Tablet can be taken with or without food. However, it is advised to take it at the same time each day, as this helps to maintain a consistent level of medicine in the body. Take this medicine in the dose and duration advised by the doctor. If you miss a dose of this medicine, take it as soon as you remember. Finish the full course of treatment even if you feel better. It is important not to stop taking this medicine without talking to the doctor, as it may worsen your symptoms.

Some common side effects of this medicine include headache, nausea, and diarrhea. It may cause dizziness and sleepiness, so do not drive or do anything that requires mental focus until you know how this medicine affects you. This medicine may cause weight gain, and to control it, you should have a balanced diet and exercise regularly. Inform your doctor if you develop any unusual changes in mood or behavior, new or worsening depression, or suicidal thoughts.

Your doctor should also know about all other medicines you are taking, as many of these may make this medicine less effective or change the way it works. Inform your doctor if you are pregnant, planning pregnancy, or breastfeeding.

Uses of Upcyte PGN Tablet

Neuropathic pain

Benefits of Upcyte PGN Tablet

Neuropathic pain
Upcyte PGN Tablet helps relieve nerve pain (neuropathic pain) by calming overactive nerves (pregabalin), improving mood and pain relief (nortriptyline), repairing nerve damage (methylcobalamin), and supporting nerve and bone health (vitamin D3). It reduces burning, tingling, and stabbing pain, improving comfort and quality of life.

Side effects of Upcyte PGN Tablet

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Upcyte PGN

Constipation
Sleepiness
Dizziness
Tiredness
Blurred vision
Dryness in mouth

How to use Upcyte PGN Tablet

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Upcyte PGN Tablet may be taken with or without food.

How Upcyte PGN Tablet works

Upcyte PGN Tablet combines four medicines: pregabalin, nortriptyline, methylcobalamin, and vitamin D3. Pregabalin is an alpha-2 delta ligand that decreases pain by modulating the calcium channel activity of the nerve cells. Nortriptyline is a tricyclic antidepressant that increases the levels of chemical messengers (serotonin and noradrenaline) that stop the movement of pain signals in the brain. Methylcobalamin is a form of vitamin B that helps produce myelin, a substance that protects nerve fibers and rejuvenates damaged nerve cells. Vitamin D3 helps nerves send messages properly in the body. It supports brain chemicals, protects nerve coverings, and reduces swelling, which keeps nerves healthy and helps relieve pain. Together, they relieve neuropathic pain (pain from damaged nerves).

Quick tips

Upcyte PGN Tablet is used to treat certain types of long-lasting pain caused by damage to nerves.
Inform your doctor if you are taking any other pain-relieving medicines.
Inform your doctor if you have a history of seizures.
Immediately seek medical help if you experience hallucinations, fever, sweating, shivering, a fast heart rate, muscle twitching, or loss of coordination.
Along with taking Upcyte PGN Tablet, your doctor might advise you to undergo physiotherapy to get relief from pain.

Safety advice

Alcohol

UNSAFE

Do not drink alcohol while you are taking this medicine. Upcyte PGN Tablet may cause excessive drowsiness when taken with alcohol.

Pregnancy

CONSULT YOUR DOCTOR

The safety of Upcyte PGN Tablet during pregnancy has not been established. There are no adequate and well-controlled studies in pregnant women, and animal data on reproductive toxicity are insufficient. Your doctor will weigh the benefits and any potential risks before prescribing.

Breast feeding

CONSULT YOUR DOCTOR

Upcyte PGN Tablet may be unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby. It should be used only if the expected benefit outweighs the potential risk. Please consult your doctor.

Driving

UNSAFE

Upcyte PGN Tablet may cause side effects that could affect your ability to drive.
As Upcyte PGN Tablet may affect your alertness which may affect your ability to drive.

Kidney

SAFE IF PRESCRIBED

Upcyte PGN Tablet is probably safe to use in patients with kidney disease. Limited data suggest dose adjustment may not be needed.

Liver

SAFE IF PRESCRIBED

Upcyte PGN Tablet is probably safe to use in patients with liver disease. Limited data suggest dose adjustment may not be needed.

Frequently asked questions

How quickly does Upcyte PGN Tablet work?

The exact time Upcyte PGN Tablet takes to work is not known. However, you may expect improvement in pain relief in a few weeks of regular use. The full benefit may take longer and it depends on the condition and its severity.

What to do if I experience a rash over my body?

Experiencing rash over the body may be a sign of an adverse reaction due to Upcyte PGN Tablet. You should stop taking Upcyte PGN Tablet and report it to your prescribing doctor at the earliest.

Does Upcyte PGN Tablet cause dizziness?

Dizziness or drowsiness is a side effect of Upcyte PGN Tablet. If you feel dizzy or drowsy after taking Upcyte PGN Tablet, avoid indulging in activities requiring alertness. If these symptoms become severe, consult your prescribing doctor.

How long does Upcyte PGN Tablet take to work?

You may start feeling relief within a few days, but it can take a few weeks for full benefits. Take it regularly as prescribed by your doctor.

Can I stop taking Upcyte PGN Tablet suddenly?

No, stopping Upcyte PGN Tablet suddenly may cause withdrawal symptoms or worsen your condition. Always consult your doctor before stopping or changing the dose.

Who should not take Upcyte PGN Tablet?

Individuals should not take Upcyte PGN Tablet if they are allergic to pregabalin, nortriptyline, methylcobalamin, vitamin D3, and other ingredients present in the Upcyte PGN Tablet formulation. This is particularly if they have/had issues with the heart and/or are recovering from a heart attack.

Fact Box

Habit Forming

Therapeutic Class

NEURO CNS

References

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Disclaimer

Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: Medicyte Pharmaceuticals Pvt Ltd
Address: SHOP NO.3, ABHIYANTA CHS LTD., PLOT NO.64A SECTOR-21, KHARGHAR NAVI MUMBAI Raigarh MH 410210 IN , - , .

Vendor Details

Country of origin: India

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