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Twinrix Paediatric Injection is a prescription medicine. This combination of two vaccines is used to prevent Hepatitis A and B infections. It promotes the immune system to act against microorganisms to prevent such infections.

Written By Dr. Syeda Aafia, MBA, BDS,
Reviewed By Dr. Mekhala Chandra, MD, MBBS,
Last updated on 10 Aug 2026 | 01:02 AM (IST)
₹664 MRP ₹762.313% off 
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General Information

Contains

Freeze-dried Live Attenuated Hepatitis A Vaccine (360ELISA)+ Hepatitis B Vaccine (rDNA) (10mcg)

Marketer

Glaxo SmithKline Pharmaceuticals Ltd

Storage

Store in a refrigerator (2 - 8°C). Do not freeze.
The content is shown in English
Twinrix Paediatric Injection image
Twinrix Paediatric Injection image

Product introduction

Twinrix Paediatric Injection is to be administered by healthcare professionals. It may cause pain and irritation at the site of infusion. This usually goes away with time. It can be taken by patients irrespective of age.

Twinrix Paediatric Injection is generally well tolerated by patients and is also safe in children and babies, however, it has a few side effects such as fever, weakness, headache, etc. It is important to inform your doctor if you have any kidney or liver disease. Unusual crying can be observed in children or babies.

Uses of Twinrix Injection

Benefits of Twinrix Injection

Prevention of Hepatitis A infection
Hepatitis A is an inflammation of the liver caused by infection with the hepatitis A virus. Twinrix Paediatric Injection helps your body develop immunity by forming antibodies that your body needs for protection against the hepatitis A virus. It is given by an injection into a muscle only by a doctor or nurse.
Prevention of Hepatitis B infection
Hepatitis B is an infection of the liver caused by the Hepatitis B virus (HBV). It can spread from person to person through blood, semen or other body fluids. It can cause mild illness lasting a few weeks or can lead to a serious, lifelong illness. Twinrix Paediatric Injection is given to prevent hepatitis B infection. It is advisable to consult your doctor for complete information regarding vaccination schedules.

Side effects of Twinrix Injection

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Twinrix
  • Fatigue
  • Injection site reactions (pain, swelling, redness)
  • Nausea
  • Diarrhea
  • General discomfort
  • Vomiting
  • Irritability
  • Headache
  • Red spots or bumps

How to use Twinrix Injection

Your doctor or nurse will give you this medicine. Kindly do not self administer.

How Twinrix Injection works

Twinrix Paediatric Injection is a combination of two medicines: Freeze-dried Live Attenuated Hepatitis A Vaccine and Hepatitis B Vaccine (rDNA) which prevent Hepatitis A and Hepatitis B. They help develop immunity by initiating a mild infection. This type of infection does not cause illness but stimulates the body's immune system to produce antibodies (proteins) to protect against any future infections.

Quick tips

  • Twinrix Paediatric Injection is used to immunize adults 18 years of age and above who are at risk of both hepatitis A and hepatitis B infection.
  • It consists of three doses, the first administered at the selected date, the second one month later, and the third six months after the first dose.
  • The vaccine will not prevent infection caused by other agents such as hepatitis C and hepatitis E and other pathogens known to infect the liver.

Safety advice

Alcohol

Alcohol

CONSULT YOUR DOCTOR
It is not known whether it is safe to consume alcohol with Twinrix Paediatric Injection. Please consult your doctor.
Pregnancy

Pregnancy

CONSULT YOUR DOCTOR
The safety of Twinrix Paediatric Injection during pregnancy has not been established. There are no adequate and well-controlled studies in pregnant women, and animal data on reproductive toxicity are insufficient. Your doctor will weigh the benefits and any potential risks before prescribing.
Breast feeding

Breast feeding

SAFE IF PRESCRIBED
Twinrix Paediatric Injection may be safe to use during breastfeeding. Animal studies have shown low or no adverse effects to the developing baby; however, there are limited human studies.
Driving

Driving

SAFE
Twinrix Paediatric Injection does not usually affect your ability to drive.
Kidney

Kidney

CAUTION
Twinrix Paediatric Injection should be used with caution in patients with severe kidney disease. Dose adjustment may be needed.
Liver

Liver

SAFE IF PRESCRIBED
Twinrix Paediatric Injection is probably safe to use in patients with liver disease. Limited data suggest dose adjustment may not be needed.

Fact Box

Habit Forming

No

Therapeutic Class

VACCINES

Related lab tests

Hepatitis A Virus - IgG

Hepatitis A Virus - IgM

Hepatitis A virus - Total Antibody

Hepatitis B (Core) IgM Antibody

Hepatitis B e (Envelop) Antigen

Hepatitis B s (Surface) Antigen

Liver Function Test

References

  1. Twinrix [Hepatitis A & Hepatitis B (Recombinant) Vaccine]. Rixensart, Belgium: GlaxoSmithKline Biologicals; 2001 [revised Dec. 2018]. [Accessed 15 Jul. 2019] (online) Available from:
  2. Twinrix Adult Vaccine: Hepatitis A Vaccine and Hepatitis B Vaccine. Uxbridge, Middlesex: GlaxoSmithKline UK; 1996 [revised 24 Dec. 2018]. [Accessed 15 Jul. 2019] (online) Available from:
  3. Twinrix Paediatric [Hepatitis A (inactivated) and hepatitis B (rDNA) (HAB) vaccine (adsorbed)]. Rixensart, Belgium: GlaxoSmithKline Biologicals; 2018. [Accessed 15 Jul. 2019] (online) Available from:
  4. Hepatitis A & Hepatitis B (Recombinant) Vaccine [Prescribing Information]. Rixensart, Belgium: GlaxoSmithKline Biologicals; 2018. [Accessed 19 Oct. 2023] (online) Available from:
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Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: Glaxo SmithKline Pharmaceuticals Ltd
Address: Dr. Annie Besant Road, Mumbai - 400 030

Vendor Details

Country of origin: India

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