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Tolpidol Plus Tablet is a combination of two medicines used in the treatment of pain due to muscle spasm. It improves the movement of muscles and provides relief from pain and discomfort associated with muscle spasms.

Written By Dr. Swati Mishra, BDS,
Reviewed By Dr. Mekhala Chandra, MD, MBBS,
Last updated on 19 Sep 2025 | 03:30 PM (IST)
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Tolpidol Plus Tablet image
Tolpidol Plus Tablet image

Product introduction

Tolpidol Plus Tablet should be taken with food. This will prevent you from getting an upset stomach. You should take it regularly as advised by your doctor. Do not take more or use it for a longer duration than recommended by your doctor.

Using this medicine can cause some common side effects such as dizziness, weakness, and sleepiness. If any of these side effects bother you or do not go away with time, you should let your doctor know. Your doctor may help with ways to reduce or prevent these side effects.

The medicine may not be suitable for everybody. Before taking it, let your doctor know if you have any problems with your heart, kidneys, or liver. To make sure it is safe for you, let your doctor also know all the other medicines you are taking. Pregnant and breastfeeding mothers should first consult their doctors before using the medicine.

Uses of Tolpidol Plus Tablet

  • Pain due to muscle spasm

Benefits of Tolpidol Plus Tablet

Pain due to muscle spasm
Tolpidol Plus Tablet treats pain due to muscle spasm by relaxing stiff muscles. It also reduces swelling in the muscles. Altogether, it helps in easy movement and reduces discomfort. Once you see some improvement, you can start doing therapy exercises (such as walking or breathing exercises) that will help you get your strength back more quickly. Tolpidol Plus Tablet also reduces fever that sometimes accompany a muscle spasm.

Side effects of Tolpidol Plus Tablet

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Tolpidol Plus
  • Dizziness
  • Weakness
  • Sleepiness

How to use Tolpidol Plus Tablet

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Tolpidol Plus Tablet is to be taken with food.

How Tolpidol Plus Tablet works

Tolpidol Plus Tablet is a combination of two medicines: Tolperisone and Paracetamol, which relieves pain and relaxes the muscles. Tolperisone is a muscle relaxant. It works by acting on the centers in the brain and spinal cord to relieve the muscle stiffness or spasm. Paracetamol is an analgesic (pain reliever) and an antipyretic (fever reducer). It blocks the release of certain chemical messengers in the brain that are responsible for pain and fever.

Quick tips

  • You have been prescribed Tolpidol Plus Tablet to relieve pain due to muscle spasm.
  • It is usually used along with rest and physical therapy.
  • Avoid consuming alcohol when taking Tolpidol Plus Tablet as it may cause excessive drowsiness and increase the risk of liver damage.
  • Older adults may have increased drowsiness, confusion, and higher risk of falling while taking Tolpidol Plus Tablet.
  • Do not take it with any other medicine containing acetaminophen (drugs for pain/fever or cough-and-cold) without asking your doctor first. 

Safety advice

Alcohol

Alcohol

UNSAFE
It is unsafe to consume alcohol with Tolpidol Plus Tablet.
Pregnancy

Pregnancy

CONSULT YOUR DOCTOR
Tolpidol Plus Tablet may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
Breast feeding

Breast feeding

CONSULT YOUR DOCTOR
Information regarding the use of Tolpidol Plus Tablet during breastfeeding is not available. Please consult your doctor.
Driving

Driving

UNSAFE
Tolpidol Plus Tablet may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur.
Kidney

Kidney

CAUTION
Tolpidol Plus Tablet should be used with caution in patients with severe kidney disease. Dose adjustment of Tolpidol Plus Tablet may be needed. Please consult your doctor.
However, Tolpidol Plus Tablet contains paracetamol which is considered the safest painkiller for kidney disease patients.
Liver

Liver

CAUTION
Tolpidol Plus Tablet should be used with caution in patients with liver disease. Dose adjustment of Tolpidol Plus Tablet may be needed. Please consult your doctor.
However, the use of Tolpidol Plus Tablet is not recommended in patients with severe liver disease and active liver disease.

Frequently asked questions

If you are suffering from muscle pain due to muscle injury or overuse, you should take rest. Taking rest will help you avoid any further injury and help you recover efficiently. Make sure that you take plenty of sleep and try to reduce stress. Applying an ice pack to the affected area may help in relieving pain and inflammation. If your muscle pain is due to some other disease, follow the advice of your doctor.
No, there are no reports of any patient getting addicted to Tolpidol Plus Tablet.
Tolpidol Plus Tablet is usually used for short term and can be discontinued when your pain is relieved. However, Tolpidol Plus Tablet should be continued if advised by the doctor.
Tolpidol Plus Tablet contains paracetamol. This medicine is known to cause harm to the liver especially in the doses above the recommended level. Also, avoid drinking alcohol while taking this medicine, as it may further increase your risk of liver damage. Use of this medicine should preferably be avoided in patients with underlying liver disease. Contact your doctor immediately if you notice any early signs and symptoms of liver damage such as fever, rash, loss of appetite, nausea, vomiting, fatigue, stomach pain, dark urine, yellow skin or eyes and abnormal liver enzymes.
It may take about an hour to see the initial benefit of pain relief after taking Tolpidol Plus Tablet.
Keep this medicine in the packet or the container it came in, tightly closed. Store it according to the mentioned on the pack or label. Dispose of the unused medicine. Make sure it is not consumed by pets, children and other people.

Fact Box

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User feedback

Thrice A Day
40%
Twice A Day
40%
Once A Day
20%
Others
50%
Muscle relaxation
50%
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Disclaimer

Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: Themis Medicare Ltd
Address: 11/12, Udyog Nagar, S. V. Road, Goregaon (W), Mumbai- 400104.

Vendor Details

Country of origin: India
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