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Talendep Plus Tablet

Written By Dr. Syeda Aafia, MBA, BDS
Reviewed By Dr. Mekhala Chandra, MD, MBBS
Last updated on 31 Mar 2026 | 02:31 PM (IST)
Talendep Plus Tablet is a prescription medicine used in the treatment of depression. It is a combination medicine that calms the brain by relaxing the nerve cells. It also increases the level of chemical messengers in the brain that help in regulating mood.
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General Information

Contains

Diazepam (2mg)+ Imipramine (25mg)

Marketer

Talent India

Storage

Store below 30°C
The content is shown in English
Talendep Plus Tablet image
Talendep Plus Tablet image

Product introduction

Talendep Plus Tablet can be taken with or without food. However, it is advised to take it at the same time each day as this helps to maintain a consistent level of medicine in the body. Take this medicine in the dose and duration advised by your doctor as it has habit-forming potential. If you miss a dose of this medicine, take it as soon as you remember. Finish the full course of treatment even if you feel better. It is important not to stop taking this medication suddenly without talking to your doctor as this can cause withdrawal effects like depression and difficulty sleeping.

Some common side effects of this medicine include constipation, difficulty in urination, weight gain, confusion, orthostatic hypotension (sudden lowering of blood pressure on standing). This medicine may cause weight loss. In case of losing weight, consult a dietitian for dietary supplements or try to increase your food portion. Most of the common side effects tend to be mild. Your doctor may be able to suggest ways of preventing or reducing side effects if they bother you or do not go away. Serious side effects are rare. Remember to inform your doctor if you develop any unusual changes in mood as it may lead to suicidal thoughts.

Take caution while taking medicine if you are suffering from liver disease. Your doctor should also know about all other medicines you are taking as many of these may make this medicine less effective or change the way it works. Inform your doctor if you are pregnant, planning pregnancy or breastfeeding.

Uses of Talendep Plus Tablet

Benefits of Talendep Plus Tablet

Depression
Talendep Plus Tablet is used together in depression to help manage both mood and anxiety symptoms. It supports emotional stability by improving mood and helps relieve restlessness and tension, offering more complete relief in individuals with mixed symptoms.

Side effects of Talendep Plus Tablet

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Talendep Plus
  • Difficulty in urination
  • Weight gain
  • Confusion
  • Orthostatic hypotension (sudden lowering of blood pressure on standing)
  • Tiredness
  • Blurred vision
  • Depression
  • Dryness in mouth
  • Increased heart rate
  • Constipation
  • Memory impairment
  • Uncoordinated body movements

How to use Talendep Plus Tablet

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Talendep Plus Tablet may be taken with or without food.

How Talendep Plus Tablet works

Talendep Plus Tablet is a combination of two medicines:

Quick tips

  • You have been prescribed Talendep Plus Tablet for the treatment of depression.
  • Inform your doctor immediately if you get thoughts about harming yourself or ending your life.
  • It is also advisable to inform your doctor if you get aggressive, anxiety, trouble sleeping, an increase in activity or talking more than what is normal for you, and other unusual changes in behavior or mood.
  • Do not stop taking Talendep Plus Tablet unless your doctor tells you to do so. Stopping treatment suddenly can cause problems and your doctor will probably want you to reduce your dose gradually when this becomes necessary.
  • Inform your doctor if you are taking any other antidepressants.
  • If you have hypertension, monitor your blood pressure regularly while taking Talendep Plus Tablet.
  • Try to keep your regular appointments with your doctor. This is so your doctor can check on your progress.

Safety advice

Alcohol

Alcohol

CONSULT YOUR DOCTOR
It is not known whether it is safe to consume alcohol with Talendep Plus Tablet. Please consult your doctor.
Pregnancy

Pregnancy

UNSAFE
Talendep Plus Tablet is highly unsafe during pregnancy. It can cause serious harm to the unborn baby, including birth defects and pregnancy loss. Do not use this medicine if you are pregnant or planning to become pregnant.
Breast feeding

Breast feeding

CONSULT YOUR DOCTOR
Talendep Plus Tablet may be unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby. It should be used only if the expected benefit outweighs the potential risk. Please consult your doctor.
Driving

Driving

UNSAFE
Talendep Plus Tablet may decrease alertness, affect your vision, or make you feel sleepy and dizzy. Do not drive if these symptoms occur.
As Talendep Plus Tablet may impair your alertness or cause drowsiness or blurred vision, and this may affect your ability to drive.
Kidney

Kidney

CAUTION
Talendep Plus Tablet should be used with caution in patients with kidney disease. Dose adjustment may be needed.
Liver

Liver

CAUTION
Talendep Plus Tablet should be used with caution in patients with liver disease. Dose adjustment may be needed.
Regular monitoring of liver function tests is recommended while you are taking this medicine.

Frequently asked questions

Talendep Plus Tablet is used to treat depression, especially when it is accompanied by severe anxiety, panic attacks, or sleep disturbances.<br>
Yes, Talendep Plus Tablet, particularly the diazepam component, is known to cause significant drowsiness and may impair your coordination. It is very important that you do not drive, operate heavy machinery, or do anything that requires full mental alertness until you know how this medication affects you.​<br>
Talendep Plus Tablet should be swallowed whole with a glass of water, as prescribed by your doctor. Because of its sedating effects, it is often recommended to take this medication in the evening or before bedtime, to help with sleep and minimize daytime drowsiness.​<br>
The exact time Talendep Plus Tablet takes to show benefits is not known. However, you may feel some of the calming effects within a few hours. The full antidepressant effects can take several weeks of consistent daily use to become noticeable. It is very important to continue taking the medicine as prescribed, even if you do not feel an immediate improvement in your mood.​<br>
No, you must never stop taking Talendep Plus Tablet suddenly. Abruptly stopping can lead to unpleasant and sometimes dangerous withdrawal symptoms from both the medicines present in Talendep Plus Tablet, namely, diazepam and imipramine. You should always consult your doctor, who will help you to gradually reduce the dose over time.<br>
Yes, Talendep Plus Tablet has the potential to be habit-forming, especially if it is used for a long period of time. It is crucial to only take this medication exactly as prescribed by your doctor, and not for a longer duration than recommended.<br>

Fact Box

Habit Forming

~

Therapeutic Class

NEURO CNS

References

  1. Diazepam. South San Francisco, California: Genentech USA Inc.; 2013. [Accessed 22 Apr. 2019] (online) Available from:
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Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: Talent India
Address: 1601, Karnavati Estate, GIDC, Phase III, Vatva, Ahmedabad 382445, Gujarat, India.

Vendor Details

Country of origin: India

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