Samehep Tablet

Reviewed By Dr. Mekhala Chandra, MD, MBBS

Last updated on 05 Dec 2025 | 01:00 AM (IST)

Samehep Tablet is a medicine used for the treatment of liver disease associated with reduced bile formation (intrahepatic cholestasis). It protects the liver cells from toxins and helps the liver to perform its normal functions.

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General Information

Contains

S-Adenosyl L-Methoinine Disulfate Tosylate (400mg)

Marketer

Jupiter Formulations Private Limited

Storage

Store below 30°C

The content is shown in English

Product introduction

Samehep Tablet may be taken with or without food. The dose will depend on the severity of your condition and your body weight. It is best swallowed whole, but you may need to break them to get the correct dose. This medicine needs to be taken regularly to get the most benefit and you may have to take it for several months or longer, so try to get into a routine. Keep using it as prescribed even if your symptoms disappear.

Use of this medicine may cause some common side effects such as headache, dizziness, vomiting, upset stomach, diarrhea, constipation, and insomnia. Not everyone gets side effects. If you are worried about them, or they do not go away, let your doctor know. If you have problems with diarrhea your doctor may reduce the dose or stop the treatment. Drink enough water or fluids to stay hydrated in case of severe diarrhea and constipation.

Before taking this medicine, you should tell your doctor if you are pregnant, planning pregnancy, or breastfeeding. Using this medicine can reduce or increase the effect of some other medicines so tell your doctor, all other medicines you are taking. Avoid drinking alcohol as it might increase side effects.

Uses of Samehep Tablet

Treatment of Liver disease

Benefits of Samehep Tablet

Treatment of Liver disease
Liver problems can interfere with the body’s ability to remove toxins and digest food properly, leading to fatigue, poor digestion, and overall weakness. Samehep Tablet supports liver function, helps protect liver cells from damage, and improves their recovery. It aids in maintaining better liver health and reducing complications.

Side effects of Samehep Tablet

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Samehep

Headache
Dizziness
Vomiting
Upset stomach
Diarrhea
Constipation
Insomnia (difficulty in sleeping)

How to use Samehep Tablet

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Samehep Tablet may be taken with or without food.

How Samehep Tablet works

Samehep Tablet contains S-Adenosyl L-Methoinine Disulfate Tosylate, also known as SAMe, a nutritional supplement, that can restore Glutathione concentrations in the liver and also improves liver damage. SAMe is also involved in many biochemical reactions in the human body that regulate the growth, death and differentiation of hepatocytes (liver cells). Because liver function is compromised in people suffering from liver disease, supplementation with Samehep Tablet is beneficial.

All substitutes for Samehep Tablet

For information purposes only. Consult a doctor before taking any medicine.

Quick tips

Samehep Tablet is prescribed for the treatment of liver disease.
Seek immediate medical attention if you have difficulty breathing after taking the drug.
Samehep Tablet may interfere with surgery. Its use should be discontinued at least two weeks prior to surgery.
Avoid smoking and drinking as it further degrades liver functioning.
You will be regularly monitored for blood creatinine and blood/urine urea levels while on treatment with Samehep Tablet.

Safety advice

Alcohol

UNSAFE

It is unsafe to consume alcohol with Samehep Tablet

Pregnancy

CONSULT YOUR DOCTOR

The safety of Samehep Tablet during pregnancy has not been established. There are no adequate and well-controlled studies in pregnant women, and animal data on reproductive toxicity are insufficient. Your doctor will weigh the benefits and any potential risks before prescribing.

Breast feeding

CONSULT YOUR DOCTOR

Information regarding the use of Samehep Tablet during breastfeeding is not available. Please consult your doctor.

Driving

UNSAFE

Samehep Tablet may decrease alertness, affect your vision, or make you feel sleepy and dizzy. Do not drive if these symptoms occur.

Kidney

CONSULT YOUR DOCTOR

There is limited data available on the use of Samehep Tablet in patients with kidney disease. Please consult your doctor.

Liver

SAFE IF PRESCRIBED

Samehep Tablet is safe to use in patients with liver disease. No dose adjustment is recommended.

Frequently asked questions

What is Samehep Tablet used for?

Samehep Tablet is used to treat liver diseases where bile flow is reduced (intrahepatic cholestasis). It protects liver cells from harmful substances and helps the liver function normally.

How does taking Samehep Tablet help with joint pain?

Samehep Tablet is usually used to support liver health, but due to its anti‑inflammatory properties, it can also help reduce pain and improve joint function, similar to common arthritis medicines but with fewer side effects. Your doctor will evaluate the need for this medicine and advise on the dose and duration for the best results.

Can Samehep Tablet improve symptoms of depression?

Samehep Tablet is usually used to support liver health. However, some people find that it helps improve mood and reduce depression symptoms. Always use this medicine only as prescribed by your doctor.

Is Samehep Tablet natural or synthetic?

Samehep Tablet contains SAMe, which is a natural compound made by the body but can also be taken as a synthetic supplement to increase low levels.

Can Samehep Tablet help liver problems?

Samehep Tablet can support liver function and help protect liver cells. Your doctor will prescribe the dose and duration of this medicine for the best results.

Fact Box

Chemical Class

Sulfonium compounds

Habit Forming

Therapeutic Class

GASTRO INTESTINAL

Action Class

Hepatoprotective Agents

Related lab tests

Bilirubin Direct

Bilirubin Indirect

Bilirubin Total

Liver Function Test

References

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Disclaimer

Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: Jupiter Formulations Private Limited
Address: Crystal Plaza,Opposite Inorbit Mall,Andheri West Mumbai,Maharashtra.

Vendor Details

Country of origin: India

Lab tests offered by us

Why we need a prescription?

Provide right medicines

Prescriptions are complex documents. We proof read and recheck at various steps to provide you the right medication in the correct form and dose

In accordance with the law

Most medicines cannot be sold without a valid prescription, as per the Drugs and Cosmetics Act, 1940 and Rules, 1945

Samehep Tablet

Save more with additional offers

Save more with additional offers

General Information

Contains

Marketer

Storage

Product introduction

Uses of Samehep Tablet

Benefits of Samehep Tablet

Side effects of Samehep Tablet

How to use Samehep Tablet

How Samehep Tablet works

All substitutes for Samehep Tablet

Alsame Tablet

Mednosam 400 Tablet

ADEBEST 400mg Tablet

Samorac 400 Tablet

Sambrace 400 Tablet

Quick tips

Safety advice

Alcohol

Pregnancy

Breast feeding

Driving

Kidney

Liver

Frequently asked questions

What is Samehep Tablet used for?

How does taking Samehep Tablet help with joint pain?

Can Samehep Tablet improve symptoms of depression?

Is Samehep Tablet natural or synthetic?

Can Samehep Tablet help liver problems?

Fact Box

Chemical Class

Habit Forming

Therapeutic Class

Action Class

Related lab tests

Bilirubin Direct

Bilirubin Indirect

Bilirubin Total

Liver Function Test

References

Want to know more

Have issue with the content

Disclaimer

Marketer details

Vendor Details

Lab tests offered by us

Related/Popular tests