Safeguard-SR Tablet

Diclofenac (100mg)+ Misoprostol (200mcg)

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Safeguard-SR Tablet is a pain-relieving medicine. It is used to treat pain and inflammation in conditions like rheumatoid arthritis, ankylosing spondylitis, and osteoarthritis. It is also used to relieve muscle pain, back pain, toothache, or pain in the ear and throat.

Written By Dr. Swati Mishra, BDS,
Reviewed By Dr. Sachin Gupta, MD Pharmacology, MBBS,
Last updated on 27 Feb 2026 | 03:01 PM (IST)

₹240 MRP ₹265.7810% off

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General Information

Contains

Diclofenac (100mg)+ Misoprostol (200mcg)

Marketer

Pulse Pharmaceuticals

Storage

Store below 25°C

The content is shown in English

Product introduction

Safeguard-SR Tablet should be taken with food. This will prevent you from getting an upset stomach. The dose will depend on what you are taking it for and how well it helps your symptoms. You should take it as advised by your doctor. Do not take more or use it for a longer duration than recommended by the doctor.

The most common side effects of this medicine include nausea, vomiting, indigestion, diarrhea, and loss of appetite. If any of these side effects bother you or get worse, you should let your doctor know. Your doctor may be able to suggest ways of preventing or reducing the side effects.

Before taking it, you should let your doctor know if you have a history of ulcer or bleeding in your stomach, high blood pressure, or have any trouble with your heart, kidneys, or liver. Let your doctor also know about all the other medicines you are taking because they may affect, or be affected by, this medicine.

Pregnant or breastfeeding women should consult their doctor before starting treatment. You should also avoid drinking alcohol while you are taking this medicine, as alcohol can cause excessive drowsiness.

Uses of Safeguard Tablet SR

Pain relief

Benefits of Safeguard Tablet SR

Pain relief
Safeguard-SR Tablet relieves pain, reduce swelling and ease inflammation in conditions like rheumatoid arthritis, osteoarthritis and ankylosing spondolytis. It also gives relief from muscle and back pain, toothache, or pain in the ear and throat. It works by reducing substances in the body that causes pain and swelling. Safeguard-SR Tablet contains an active ingredient that protects your stomach from ulcers that may occur due to this medicine. Take it as prescribed to get the most benefit. This will help you to go about your daily activities more easily and have a better, more active, quality of life.

Side effects of Safeguard Tablet SR

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Safeguard

Nausea
Vomiting
Indigestion
Diarrhea
Loss of appetite

How to use Safeguard Tablet SR

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Safeguard-SR Tablet should be taken with or after food.

How Safeguard Tablet SR works

Safeguard-SR Tablet is a combination of two medicines: Diclofenac and Misoprostol which relieve pain.

Quick tips

Safeguard-SR Tablet is used to treat various painful conditions.
Safeguard-SR Tablet should be taken with, or straight after, a meal or snack. This helps to reduce the risk of stomach upset.
Stick to simple meals and avoid spicy rich food in order to avoid feeling sick (nausea).
Drink plenty of water while taking Safeguard-SR Tablet.
If you have asthma, symptoms such as wheeze or breathlessness might become worse by Safeguard-SR Tablet. If this happens to you, consult your doctor immediately.

Safety advice

Alcohol

CAUTION

Alcohol should be used with caution while taking Safeguard-SR Tablet.

Pregnancy

UNSAFE

Safeguard-SR Tablet is highly unsafe during pregnancy. It can cause serious harm to the unborn baby, including birth defects and pregnancy loss. Do not use this medicine if you are pregnant or planning to become pregnant.

Breast feeding

UNSAFE

Safeguard-SR Tablet is unsafe to use during breastfeeding. Data suggests that the drug may cause toxicity to the baby.

Driving

CONSULT YOUR DOCTOR

It is not known whether Safeguard-SR Tablet alters the ability to drive. Do not drive if you experience any symptoms that affect your ability to concentrate and react. Please consult your doctor.

Kidney

UNSAFE

Safeguard-SR Tablet is unsafe to use in patients with kidney disease and should be avoided.

Liver

CAUTION

Safeguard-SR Tablet should be used with caution in patients with liver disease. Dose adjustment may be needed.

Frequently asked questions

What is Safeguard-SR Tablet used for?

Safeguard-SR Tablet is prescribed to adults who have osteoarthritis, or rheumatoid arthritis, and are also at high risk of stomach, or intestinal ulcers caused by regular NSAID use. It helps relieve arthritis symptoms while reducing the risk of ulcer complications.

Who should not take Safeguard-SR Tablet?

Safeguard-SR Tablet should not be taken by people who are pregnant, have had coronary artery bypass graft (CABG) heart surgery, have an active stomach, or intestinal bleeding, have asthma, or allergic reactions triggered by aspirin, or other NSAIDs, or are allergic to diclofenac, misoprostol, or ingredients in the medicine. These conditions can lead to serious and potentially life-threatening reactions.

Why is pregnancy such a strict contraindication for Safeguard-SR Tablet?

One of the medicines present in Safeguard-SR Tablet, misoprostol, can cause miscarriage, severe uterine bleeding, premature birth, or birth defects, which is why this medicine must never be used during pregnancy or given to someone who might be pregnant. Women must be fully informed about this risk.

What heart-related risks should I know before starting Safeguard-SR Tablet?

What serious stomach or intestinal risks should I be aware of during Safeguard-SR Tablet treatment?

Safeguard-SR Tablet can cause bleeding, ulcers, or tears in the stomach or intestines, which may occur suddenly without warning symptoms. Elderly patients and those with a past ulcer or GI bleeding are at higher risk, even with the protective effect of misoprostol.

Can Safeguard-SR Tablet affect my kidneys or liver?

One of the medicines present in Safeguard-SR Tablet, diclofenac, can cause kidney problems (especially in people with dehydration, heart failure, or existing kidney disease), and can also cause liver damage. Doctors may stop the medicine if liver tests become abnormal or symptoms suggest liver disease.

What symptoms should I report immediately while taking Safeguard-SR Tablet?

While taking Safeguard-SR Tablet, you should seek urgent medical help if you notice chest pain, weakness on one side, trouble speaking, black or bloody stools, vomiting blood, severe stomach pain, yellowing of the eyes/skin, swelling, rapid weight gain, reduced urine output, or difficulty breathing, or allergic-type reactions. These may be signs of serious complications requiring immediate care.

Can Safeguard-SR Tablet trigger asthma symptoms?

Yes. People who have aspirin-sensitive asthma should not take Safeguard-SR Tablet, as it may cause dangerous breathing reactions. Even in non-aspirin-sensitive asthma, close monitoring is required.

Are there any serious skin reactions with Safeguard-SR Tablet I should watch for?

Rare but severe skin reactions such as Stevens-Johnson syndrome, widespread rash, blistering, or peeling may occur after taking Safeguard-SR Tablet. Stop the medicine, and get medical help at the first sign of skin changes.

Fact Box

Habit Forming

Therapeutic Class

PAIN ANALGESICS

References

Diclofenac + Misoprostol. Sandwich, Kent: Pfizer Limited; 2002 [revised Feb. 2019]. [Accessed 22 Apr. 2019] (online) Available from:

User feedback

Patients taking Safeguard-SR Tablet

Once A Day

96%

Twice A Week

Twice A Day

What are you using Safeguard Tablet SR for?

Pain relief

100%

How much was the improvement?

Excellent

56%

Average

44%

What were the side-effects while using Safeguard-SR Tablet?

No Side Effect

100%

How do you take Safeguard Tablet SR?

With food

100%

Please rate Safeguard-SR Tablet on price

Expensive

67%

Average

33%

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Disclaimer

Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: Pulse Pharmaceuticals
Address: Plot No.18/1 Sector-III HUDA Techno Enclave Hitech City Madhapur Hyderabad-500081 Telangana

Vendor Details

Country of origin: India

Lab tests offered by us

Why we need a prescription?

Safeguard-SR Tablet

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General Information

Contains

Marketer

Storage

Product introduction

Uses of Safeguard Tablet SR

Benefits of Safeguard Tablet SR

Side effects of Safeguard Tablet SR

How to use Safeguard Tablet SR

How Safeguard Tablet SR works

Quick tips

Safety advice

Alcohol

Pregnancy

Breast feeding

Driving

Kidney

Liver

Frequently asked questions

What is Safeguard-SR Tablet used for?

Who should not take Safeguard-SR Tablet?

Why is pregnancy such a strict contraindication for Safeguard-SR Tablet?

What heart-related risks should I know before starting Safeguard-SR Tablet?

What serious stomach or intestinal risks should I be aware of during Safeguard-SR Tablet treatment?

Can Safeguard-SR Tablet affect my kidneys or liver?

What symptoms should I report immediately while taking Safeguard-SR Tablet?

Can Safeguard-SR Tablet trigger asthma symptoms?

Are there any serious skin reactions with Safeguard-SR Tablet I should watch for?

Fact Box

Habit Forming

Therapeutic Class

References

User feedback

Patients taking Safeguard-SR Tablet

What are you using Safeguard Tablet SR for?

How much was the improvement?

What were the side-effects while using Safeguard-SR Tablet?

How do you take Safeguard Tablet SR?

Please rate Safeguard-SR Tablet on price

Want to know more

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Disclaimer

Marketer details

Vendor Details

Lab tests offered by us

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