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MRP: Rs. 148 for 1 strip(s) (15 tablets each)
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Composition for SAFEGUARD 75MG/200MCG TABLET

Diclofenac(75 mg),Misoprostol(200 mcg)

food interaction for SAFEGUARD 75MG/200MCG TABLET

alcohol interaction for SAFEGUARD 75MG/200MCG TABLET

pregnancy interaction for SAFEGUARD 75MG/200MCG TABLET

lactation interaction for SAFEGUARD 75MG/200MCG TABLET

There is no data available. Please consult doctor before consuming the drug.
Taking diclofenac with alcohol can increase your risk of stomach bleeding.
Safeguard 75mg/200mcg tablet is highly unsafe in women who are or may become pregnant.
Human and animal studies have shown significant adverse effects on the fetus and should not be given under any circumstances. Please consult your doctor.
Unknown. Human and animal studies are not available. Please consult your doctor.


Diclofenac(75 mg)


Diclofenac is used in the treatment of painful conditions of joints, lower back pain, sprains or bone fractures, inflammation of joints (frozen shoulder, gout), pain and swelling following skeletal muscle, dental and other minor surgeries. It is also used in treatment of migraine.

How it works

Diclofenac belongs to group of medicines called non-steroidal anti-inflammatory drugs (NSAIDs). It works by blocking the production of a certain chemical substance in the body that causes pain, fever, and inflammation.

Common side effects

Epigastric pain, Renal dysfunction, Stomach ulcer, Bleeding, Toxic epidermal necrolysis, Itching
Misoprostol(200 mcg)


Misoprostol is used to prevent gastric ulcers resulting from treatment with pain-killers/NSAIDs (non-steroidal anti-inflammatory drugs like ibuprofen, naproxen, indomethacin). It is also used for medical termination of pregnancy or legal abortion during early pregnancy, along with mifepristone.

How it works

Misoprostol is similar to the natural chemical prostaglandin found in the body. It acts on the stomach and intestine to create a protective lining, and thereby prevents ulcer formation. It also acts on the uterus and produces strong contractions and softens the cervix to cause abortion.

Common side effects

Constipation, Flatulence, Headache, Indigestion, Stomach pain, Vomiting, Diarrhoea


No substitutes found

Expert advice for SAFEGUARD 75MG/200MCG TABLET

  • Diclofenac should be taken with food or immediately after meals.
  • Take the medicine with food to avoid stomach upset.
  • Do not take antacids withh magnesium as they can interact with the drug.
  • Do not take diclofenac, If  you are allergic to diclofenac.
  • Do not drink alcohol while takig this drug.
  • Do not drive or use any tools or machines, if you feel dizzy, tired, have a headache or get blurred vision after taking diclofenac.

Frequently asked questions for SAFEGUARD 75MG/200MCG TABLET


Q. Is diclofenac safe?
Diclofenac (also available as voveran, dynapar) is safe if used at prescribed doses for the prescribed duration as advised by your doctor.
Q. Is diclofenac nephrotoxic?
Diclofenac can interfere with normal kidney function when taken at larger doses for a longer duration. Patients should follow the advice of the doctor regarding its uses.
Q. Is diclofenac safe in asthma?
Diclofenac may worsen the symptoms of asthma in some patients already suffering from asthma. Talk to your doctor before taking diclofenac in asthma.
Q. Is diclofenac banned in India?
Diclofenac is available over-the-counter and it is not banned in India.
Q. Is diclofenac a blood thinner / controlled substance?
Diclofenac is a pain relieving medication and it does not significantly affect the function of platelets in blood; hence it is not a blood thinner. It is not a controlled substance as it does not have the potential for abuse or addiction.
Q. Does diclofenac increase blood pressure?
Diclofenac does not have any effect on blood pressure in normal individuals. However, consult your doctor before taking diclofenac if you are already suffering from high blood pressure or any other heart disease.
Q. Does diclofenac induce sleep?
Diclofenac does not induce sleep.


Q. Is misoprostol safe?
Yes. Misoprostol is relatively safe if used as recommended. In case of any side-effects, consult your doctor.
Q. Is misoprostol available or sold over the counter?
No. Misoprostol is a prescription drug. It is not available or sold over the counter.
Q. Is misoprostol effective orally?
Yes. Misoprostol is effective orally.
Q. Is misoprostol available and legal in India?
Yes. Misoprostol is legally available in India.
Q. Can I take misoprostol with Advil, Vicodin, hydrocodone?
Misoprostol may be taken with Advil (ibuprofen), Vicodin (paracetamol and hydrocodone), and hydrocodone if prescribed by your doctor.
Q. Does misoprostol cause weight gain?
There is no evidence of misoprostol causing weight gain. If you notice any such symptoms, please consult your doctor.


Content on this page was last updated on 11 March, 2016, by Dr. Varun Gupta (MD Pharmacology)