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Risdone-Plus Tablet is a combination medicine used in the treatment of schizophrenia. It works by modulating the action of certain chemical messengers in the brain that affect thoughts.

Written By Dr. Swati Mishra, BDS,
Reviewed By Dr. Rajeev Sharma, MBA, MBBS,
Last updated on 07 Apr 2026 | 02:54 PM (IST)
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General Information

Contains

Risperidone (3mg)+ Trihexyphenidyl (2mg)

Marketer

Intas Pharmaceuticals Ltd

Storage

Store below 30°C
The content is shown in English
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Risdone-Plus Tablet image
Risdone-Plus Tablet image
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Risdone-Plus Tablet image

Product introduction

Risdone-Plus Tablet is taken with or without food, preferably at night. However, it is advised to take it at the same time each day, as this helps maintain a consistent level of medicine in the body. Take this in the dose and duration advised by your doctor. If you miss a dose of this medicine, take it as soon as you remember. It is important not to stop this medicine suddenly without talking to the doctor, as it may worsen your symptoms.


Some common side effects of this medicine include nausea, constipation, upper respiratory tract infection, urinary tract infection, tremor, blurred vision, and dryness in the mouth. Initially, this medicine may cause a sudden drop in blood pressure when you change positions, so it is better to rise slowly if you have been sitting or lying down. It also causes dizziness and sleepiness. So, do not drive or do anything that requires mental focus until you know how this medicine affects you. This medicine may increase your weight, blood sugar, and cholesterol, but modifying your lifestyle by having a healthy diet and exercising regularly can reduce these side effects.


Your doctor should also know about all other medicines you are taking, as many of these may make this medicine less effective or change the way it works. Inform your doctor if you are pregnant, planning pregnancy, or breastfeeding.

Uses of Risdone-Plus Tablet

Benefits of Risdone-Plus Tablet

Treatment of Schizophrenia
Schizophrenia is a mental disorder in which a person’s thinking ability, feelings, and behavior become abnormal. Risdone-Plus Tablet helps restore the chemical imbalances in the brain that are responsible for such changes. It improves thoughts and behavior and enhances the quality of life. Do not stop taking it unless advised by the doctor. It can take several weeks for your symptoms to improve, so keep using the medicine even if you do not think it is working.

Side effects of Risdone-Plus Tablet

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Risdone-Plus
  • Nausea
  • Constipation
  • Dryness in mouth
  • Weight gain
  • Sleepiness
  • Orthostatic hypotension (sudden lowering of blood pressure on standing)
  • Increased prolactin level in blood
  • Nervousness
  • Upper respiratory tract infection
  • Urinary tract infection
  • Tremors
  • Blurred vision
  • Headache
  • Drooling
  • Nasal congestion (stuffy nose)

How to use Risdone-Plus Tablet

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Risdone-Plus Tablet may be taken with or without food.

How Risdone-Plus Tablet works

Risdone-Plus Tablet is a combination of two medicines: Risperidone and Trihexyphenidyl. Risperidone is an atypical antipsychotic that works by balancing the levels of chemical messengers (dopamine and serotonin) to improve mood, thoughts, and behavior. Trihexyphenidyl is an anticholinergic that works on the nervous system and corrects some of the chemical imbalances that cause Parkinson's disease and certain side effects occurring during antipsychotic treatment.

All substitutes for Risdone-Plus Tablet

For information purposes only. Consult a doctor before taking any medicine.

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Quick tips

  • Use caution while driving or doing anything that requires concentration, as Risdone-Plus Tablet can cause dizziness and sleepiness.
  • Avoid consuming alcohol while taking this medication, as it may lower its efficacy.
  • It can cause dry mouth. Maintain good oral hygiene, drink water, chew sugarless gum, or suck on hard candy for the dry mouth.
  • It may cause an increase in weight, blood sugar, cholesterol, and triglycerides (fat). Eat healthy, exercise, and monitor your levels regularly.
  • Inform your doctor if you have glaucoma or trouble passing urine.
  • Do not stop taking Risdone-Plus Tablet without talking to your doctor first, as it may cause a worsening of symptoms.

Safety advice

Alcohol

Alcohol

UNSAFE
Do not drink alcohol while you are taking this medicine. Risdone-Plus Tablet may cause excessive drowsiness when taken with alcohol.
Pregnancy

Pregnancy

UNSAFE
Risdone-Plus Tablet is highly unsafe during pregnancy. It can cause serious harm to the unborn baby, including birth defects and pregnancy loss. Do not use this medicine if you are pregnant or planning to become pregnant.
Breast feeding

Breast feeding

CONSULT YOUR DOCTOR
Risdone-Plus Tablet may be unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby. It should be used only if the expected benefit outweighs the potential risk. Please consult your doctor.
Driving

Driving

UNSAFE
Risdone-Plus Tablet may decrease alertness, affect your vision, or make you feel sleepy and dizzy. Do not drive if these symptoms occur.
Risdone-Plus Tablet can cause blurring of vision, dizziness, mild nausea, and mental confusion in some cases. This may affect your ability to drive.
Kidney

Kidney

CAUTION
Risdone-Plus Tablet should be used with caution in patients with kidney disease. Dose adjustment may be needed.
Liver

Liver

CAUTION
Risdone-Plus Tablet should be used with caution in patients with liver disease. Dose adjustment may be needed.

Frequently asked questions

Risdone-Plus Tablet is used to manage symptoms of schizophrenia and other psychiatric conditions. It also helps reduce movement-related side effects caused by antipsychotic medications. Risdone-Plus Tablet combines two medicines: risperidone, which treats mood and behavior symptoms, and trihexyphenidyl, which helps control movement problems like stiffness or tremors.
The duration of treatment with Risdone-Plus Tablet depends on your condition, how well you are responding, and your doctor’s ongoing evaluation. Keep taking it even if you start to feel better, and stop only when your doctor tells you so.
Yes. To support your treatment with Risdone-Plus Tablet, try to stick to a regular sleep schedule, eat a balanced diet, stay hydrated, do light exercise, manage stress, avoid disruptions to your routine, and attend regular doctor visits.
Yes. Avoid taking Risdone-Plus Tablet with acidic foods or drinks like citrus fruits or juices, as they may reduce its effectiveness. Also, do not consume alcohol while on Risdone-Plus Tablet, as it can lower the medicine’s effect and increase side effects.
Avoid taking Risdone-Plus Tablet if you are allergic to any of its ingredients, have glaucoma, an enlarged prostate, problems with gut movement (such as delayed stomach emptying), or if you are an elderly person with dementia, as it may increase the risk of stroke or death.
The serious side effects of Risdone-Plus Tablet are high fever, muscle stiffness, or confusion (possible signs of neuroleptic malignant syndrome), uncontrolled movements (tardive dyskinesia), severe dizziness/fainting (due to low blood pressure), increased thirst and frequent urination (signs of high blood sugar), painful, long-lasting erection (priapism), etc. If you notice any of these or other unusual symptoms, contact your doctor immediately.

Fact Box

Habit Forming

No

Therapeutic Class

NEURO CNS

References

  1. Risperidone. County Cork, Ireland: Janssen Pharmaceutical; 1993. [Accessed 22 Apr. 2019] (online) Available from:
  2. Trihexyphnidyl. Huddersfield, West Yorkshire: Genus Pharmaceuticals; 2011 [revised 18 Dec. 2018]. [Accessed 22 Apr. 2019] (online) Available from:
  3. Trihexyphnidyl. Amara Region, Ethiopia: Humanwell Pharmaceutical Ethiopia PLC;. [Accessed 02 Apr. 2025] (online) Available from:
  4. Trihexyphnidyl Hydrochloride [Product Information]. Greenville, SC: Pharmaceutical Associates, Inc.; [Accessed 02 Apr. 2025] (online) Available from:
  5. Trihexyphnidyl Hydrochloride [Product Information]. Morgantown, WV: Greenstone LLC; [Accessed 02 Apr. 2025] (online) Available from:
  6. Trihexyphnidyl Hydrochloride and Risperidone [Product Information]. Mumbai, Maharashtra.: Alkem Laboratories Limited. [Accessed 02 Apr. 2025] (online) Available from:
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User feedback

Twice A Day
60%
Thrice A Day
20%
Once A Day
20%
Schizophrenia
70%
Others
26%
Drug induced abnormal movements
4%
Average
43%
Poor
33%
Excellent
24%
Sleepiness
25%
Constipation
25%
Dryness in mouth
17%
Nausea
12%
Weight gain
12%
With food
82%
Empty stomach
18%
Expensive
37%
Not Expensive
37%
Average
27%
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Disclaimer

Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: Intas Pharmaceuticals Ltd
Address: Chinubhai Centre, Off. Nehru Bridge, Ashram Road, Ahmedabad - 380009. Gujarat. India.

Vendor Details

Country of origin: India
A licensed vendor partner from your nearest location will deliver Risdone-Plus Tablet. Once the pharmacy accepts your order, the details of the pharmacy will be shared with you. Acceptance of your order is based on the validity of your doctor's ℞ and the availability of this medicine.

In case of any issues, contact us

Email ID: [email protected]
Phone Number: 0124-4166666
Address: 5th Floor Tower - B of the Presidency Building, 46/4 Mehrauli Gurgaon Road, Sector 14, Gurugram, Haryana-122001, India

Lab tests offered by us

Why we need a prescription?
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Most medicines cannot be sold without a valid prescription, as per the Drugs and Cosmetics Act, 1940 and Rules, 1945
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