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Rabefen AP Tablet

Written By Dr. Subita Alagh, BDS
Reviewed By Dr. Mekhala Chandra, MD, MBBS
Last updated on 01 Dec 2025 | 12:38 AM (IST)
Rabefen AP Tablet is a pain-relieving medicine. It is used to treat pain and inflammation in conditions like rheumatoid arthritis, ankylosing spondylitis, and osteoarthritis. It may also be used to relieve muscle pain, back pain, toothache, or pain in the ear and throat.
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General Information

Contains

Aceclofenac (100mg)+ Paracetamol (500mg)+ Rabeprazole (20mg)

Marketer

M.M Pharma

Storage

Store below 30°C
The content is shown in English
Rabefen AP Tablet image
Rabefen AP Tablet image

Product introduction

Rabefen AP Tablet also prevents and reduces the chances of acid reflux, heartburn, and stomach ulcers. This medicine can be taken with or without food. The dose will depend on what you are taking it for and how well it helps your symptoms. You should take it as advised by your doctor. Do not take more or use it for a longer duration than recommended by the doctor.

This medicine's most common side effects include nausea, diarrhea, constipation, stomach pain, flatulence, and loss of appetite. If any of these side effects do not resolve with time or get worse, you should let your doctor know. Your doctor may be able to suggest ways of preventing or reducing them.

Before taking it, you should let your doctor know if you have a history of ulcer or bleeding in your stomach, high blood pressure, or have any problems with your heart, kidneys, or liver. Let your doctor also know about all the other medicines you are taking to make sure they are safe.

Pregnant or breastfeeding women should consult their doctor before starting treatment. You should also avoid drinking alcohol while you are taking this medicine, as alcohol can cause excessive drowsiness.

Uses of Rabefen AP Tablet

Benefits of Rabefen AP Tablet

Pain relief
Rabefen AP Tablet is a combination medicine used for short-term relief of pain, inflammation, and swelling in conditions that affect joints and muscles. It works by blocking chemical messengers in the brain that tell us we have pain. It can help relieve pain in conditions like rheumatoid arthritis and osteoarthritis. But, this pain-relieving action may damage the inner lining of the stomach. Therefore, this medicine also has an active ingredient called Rabeprazole, which reduces the acid secretion in our stomach, thereby reducing the damage caused by the painkillers.

Take it as it is prescribed to get the most benefit. Do not take more or longer than needed as that can be dangerous. In general, you should take the lowest dose that works, for the shortest possible time. This will help you to go about your daily activities more easily and have a better, more active, quality of life.

Side effects of Rabefen AP Tablet

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Rabefen AP
  • Nausea
  • Diarrhea
  • Constipation
  • Stomach pain
  • Flatulence
  • Loss of appetite
  • Weakness
  • Flu-like symptoms

How to use Rabefen AP Tablet

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Rabefen AP Tablet may be taken with or without food.

How Rabefen AP Tablet works

Rabefen AP Tablet is a combination of two pain relievers (Aceclofenac, Paracetamol) and a proton pump inhibitor (Rabeprazole). The pain relievers work by blocking the release of certain chemical messengers that cause pain and inflammation (redness and swelling). However, they may cause damage to the stomach lining. The proton-pump inhibitor is added to reduce acid secretion and prevent this damage.

Quick tips

  • Rabefen AP Tablet should be taken with food to avoid getting an upset stomach
  • It may cause dizziness and sleepiness. Don't drive or do anything that requires mental focus until you know how it affects you.
  • Avoid consuming alcohol when taking this medicine as it may cause excessive drowsiness and increase the risk of liver damage.
  • Do not take it with any other medicine containing acetaminophen (drugs for pain/fever or cough-and-cold) without asking your doctor first. 
  • Your doctor may regularly monitor your kidney function, liver function and levels of blood components if you are taking this medicine for a long duration.

Safety advice

Alcohol

Alcohol

UNSAFE
It is unsafe to consume alcohol with Rabefen AP Tablet
Pregnancy

Pregnancy

CONSULT YOUR DOCTOR
The safety of Rabefen AP Tablet during pregnancy has not been established. There are no adequate and well-controlled studies in pregnant women, and animal data on reproductive toxicity are insufficient. Your doctor will weigh the benefits and any potential risks before prescribing.
Breast feeding

Breast feeding

CONSULT YOUR DOCTOR
Information regarding the use of Rabefen AP Tablet during breastfeeding is not available. Please consult your doctor.
Driving

Driving

UNSAFE
Rabefen AP Tablet may decrease alertness, affect your vision, or make you feel sleepy and dizzy. Do not drive if these symptoms occur.
Kidney

Kidney

CAUTION
Rabefen AP Tablet should be used with caution in patients with kidney disease. Dose adjustment may be needed.
Use of Rabefen AP Tablet is not recommended in patients with severe kidney disease.
Liver

Liver

CAUTION
Rabefen AP Tablet should be used with caution in patients with liver disease. Dose adjustment may be needed.
However, the use of Rabefen AP Tablet is not recommended in patients with severe liver disease and active liver disease.

Frequently asked questions

Rabefen AP Tablet is a combination of three medicines: Aceclofenac, Paracetamol and Rabeprazole. This medication helps in relieving pain and inflammation. Aceclofenac and Paracetamol work by lowering the levels of those chemical substances in the body which cause pain and inflammation. Rabeprazole helps in preventing the digestive problem that may occur due to Aceclofenac.
Rabefen AP Tablet, when used for long-term pain relief, should be continued for as long as advised by your doctor. It can be discontinued if you are using it for short-term pain relief.
Yes, the use of Rabefen AP Tablet can cause nausea and vomiting. Taking it with milk, food or with antacids can prevent nausea. Avoid taking fatty or fried foods along with this medication. In case of vomiting, drink plenty of water or other fluids by taking small and frequent sips. Talk to your doctor if vomiting persists and you notice signs of dehydration like dark colored and strong-smelling urine and a low frequency of urination. Do not take any other medicine without speaking to a doctor.
Yes, the use of Rabefen AP Tablet can cause dizziness (feeling faint, weak, unsteady or lightheaded) in some patients. If you feel dizzy or lightheaded it is better to rest for some time and resume once you feel better.
Yes, the long-term use of Rabefen AP Tablet can cause damage to the kidneys. Normal kidneys produce a chemical called prostaglandins that protects them from damage. Use of painkillers lowers the levels of prostaglandins in the body leading to kidney damage on long-term use. Use of painkillers is not recommended to patients with underlying kidney disease.
No, taking a higher than the recommended dose of Rabefen AP Tablet can increase the risks of side effects like nausea, vomiting, heartburn, indigestion, diarrhea and can also damage your kidneys on long-term use. If you are experiencing increased severity of pain or the pain is not relieved by the recommended doses of this medicine, please consult your doctor for re-evaluation.
Keep this medicine in the container or the pack it came in, tightly closed. Store it according to the instructions mentioned on the pack or label. Dispose of the unused medicine. Make sure it is not consumed by pets, children and other people.

Fact Box

Habit Forming

No

Therapeutic Class

PAIN ANALGESICS

References

  1. Zeelab Pharmacy: Aceclofenac + Paracetamol + Rabeprazole [Prescribing Information]. [Accessed 24 Nov. 2025]. Available from:
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Disclaimer

Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: M.M Pharma
Address: AE-75, 3rd Street, Anna Nagar, Chennai- 600 040., Tamilnadu, India.

Vendor Details

Country of origin: India

Lab tests offered by us

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