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Pegalup Oral Solution

Potassium Chloride (0.0466gm)+ Sodium Chloride (0.3507gm)+ Sodium Bicarbonate (0.1785gm)+ Polyethylene Glycol (13.125gm)

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Pegalup Oral Solution is a combination medicine used in the treatment of constipation. The medicine works by drawing water into the intestines and softening the stool, which promotes bowel movements. It also helps in maintaining electrolyte balance and neutralizing stomach acid.

Written By Dr. Subita Alagh, BDS,
Reviewed By Dr. Rajeev Sharma, MBA, MBBS,
Last updated on 02 Mar 2026 | 12:39 PM (IST)

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Pegalup Oral Solution

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General Information

Contains

Potassium Chloride (0.0466gm)+ Sodium Chloride (0.3507gm)+ Sodium Bicarbonate (0.1785gm)+ Polyethylene Glycol (13.125gm)

Marketer

Lupin Ltd

Storage

Store below 30°C

The content is shown in English

Product introduction

Take Pegalup Oral Solution in the dose and duration as advised by the doctor. The dose you are given will depend on the severity of your condition and how you respond to the medicine. You should keep taking this medicine for as long as your doctor recommends. If you stop treatment too early your symptoms may come back and your condition may worsen.

The medicine is usually safe with little or no side effects. However, let your doctor know if you experience any symptoms on taking the medicine. Lifestyle modifications like having a fiber-rich diet, increasing fluid intake, and regular exercise can help you to get better results.

Before taking this medicine, let your doctor know about all other medications you are taking as some may affect, or be affected by this medicine. You should also tell your doctor if you have any liver diseases so that your doctor can prescribe a suitable dose for you. Pegalup Oral Solution is generally considered safe to be used during pregancy or breastfeeding.

Uses of Pegalup Oral Solution

Treatment of Constipation

Benefits of Pegalup Oral Solution

Treatment of Constipation
Pegalup Oral Solution provides relief from constipation by softening the stool, increasing its volume, and facilitating easier passage through the intestines. Use it in the exact dose and duration advised by the doctor for maximum benefits.

Side effects of Pegalup Oral Solution

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Pegalup

Limited data available

How to use Pegalup Oral Solution

Take this medicine in the dose and duration as advised by your doctor. Check the label for directions before use. Measure it with a measuring cup and take it by mouth. Shake well before use. Pegalup Oral Solution may be taken with or without food.

How Pegalup Oral Solution works

Pegalup Oral Solution contains potassium chloride, sodium chloride, sodium bicarbonate, and polyethylene glycol. Potassium chloride works by raising potassium levels in your blood. Sodium chloride is a purified salt solution which works by replenishing salt and electrolyte levels in the body. Sodium bicarbonate is an alkalizer. It works by increasing the pH of blood and urine, thereby correcting metabolic acidosis (high acid levels in the body). It also speeds up the removal of toxic substances from the body in certain types of poisoning. In case of excessive fluid loss (such as in diarrhea), it works by replenishing salt and electrolyte levels. Polyethylene glycol works by drawing water into the intestine through osmosis, which makes the stool soft and easier to pass. It also helps clean out the intestines prior to medical procedures or examination.

All substitutes for Pegalup Oral Solution

For information purposes only. Consult a doctor before taking any medicine.

Quick tips

Take Pegalup Oral Solution exactly as advised by your doctor, typically after dissolving the contents in the prescribed amount of water. Do not take it directly without mixing it with water, as it may irritate your stomach or cause an electrolyte imbalance.
Drink plenty of clear fluids (like water or clear soups) along with medicine to prevent dehydration and support the bowel cleansing or rehydration process, depending on the intended use.
Do not eat solid food for at least 2 hours before and after taking Pegalup Oral Solution, especially if it is being used for bowel preparation before a procedure like a colonoscopy.
Stop taking this medicine and contact your doctor if you feel bloated, nauseous, vomit persistently, or experience dizziness or irregular heartbeat. These may indicate fluid or electrolyte disturbances.
Mix Pegalup Oral Solution freshly each time and use immediately. Do not store any leftover prepared medicine, as it may lose its effectiveness or become unsafe to consume.

Safety advice

Alcohol

CONSULT YOUR DOCTOR

It is not known whether it is safe to consume alcohol with Pegalup Oral Solution. Please consult your doctor.

Pregnancy

CONSULT YOUR DOCTOR

The safety of Pegalup Oral Solution during pregnancy has not been established. There are no adequate and well-controlled studies in pregnant women, and animal data on reproductive toxicity are insufficient. Your doctor will weigh the benefits and any potential risks before prescribing.

Breast feeding

SAFE IF PRESCRIBED

Available human data suggest that the drug does not pass into breast milk in clinically significant amounts and is unlikely to harm the infant.

Driving

CONSULT YOUR DOCTOR

It is not known whether Pegalup Oral Solution alters the ability to drive. Do not drive if you experience any symptoms that affect your ability to concentrate and react. Please consult your doctor.

Kidney

CAUTION

Pegalup Oral Solution should be used with caution in patients with kidney disease. Dose adjustment may be needed.

Liver

CAUTION

Pegalup Oral Solution should be used with caution in patients with liver disease. Dose adjustment may be needed.

Frequently asked questions

What is Pegalup Oral Solution used for?

Pegalup Oral Solution is used as a bowel cleanser for colonoscopy procedures, certain bowel surgeries, and other bowel examinations. It helps empty the intestines by causing watery stools, making it easier for doctors to examine the colon.

How should I take Pegalup Oral Solution for colonoscopy preparation?

You must mix the Pegalup Oral Solution with lukewarm water to make 4 liters of clear solution. Drink 240 mL (about 1 glass) every 10 minutes until the full volume is consumed or your stool becomes watery and clear. The solution should never be taken as dry powder or mixed with flavored drinks unless advised by the doctor.

Can I take my regular medicines with this colon preparation Pegalup Oral Solution?

No. Do not take other oral medications within 1 hour of drinking the Pegalup Oral Solution, as they may not be absorbed properly. Inform your doctor about all medications, especially those that affect kidneys, heart rhythm, or fluid balance.

Who should not take Pegalup Oral Solution?

Individuals should not take Pegalup Oral Solution if they have intestinal blockage (ileus), bowel perforation, toxic colitis, severe kidney or heart problems, or known allergy to PEG or any of the ingredients present in Pegalup Oral Solution.

Can I eat or drink before taking Pegalup Oral Solution for colonoscopy?

Yes, you may have a light breakfast and clear liquids earlier in the day before you consume Pegalup Oral Solution. Avoid red or purple-colored drinks, dairy, or solid foods. After starting the prep, drink only clear fluids up to 2 hours before the colonoscopy.

How long does Pegalup Oral Solution take to start working?

You may have your first bowel movement within 1 hour after drinking Pegalup Oral Solution. Continue drinking the solution until your stool is clear and watery, which means your bowel is fully cleaned.

Can Pegalup Oral Solution cause dehydration or electrolyte imbalance?

Yes. Pegalup Oral Solution can cause loss of body fluids and essential salts, leading to dehydration, kidney problems, or irregular heartbeat. Drink plenty of clear fluids during the prep, and stop if you feel faint, dizzy, or very weak.

What should I do if I vomit after taking the Pegalup Oral Solution?

If you vomit and cannot keep drinking Pegalup Oral Solution, stop drinking temporarily. Try again after a short break. If vomiting continues, contact your doctor as you may need an alternative preparation method.

Fact Box

Habit Forming

Therapeutic Class

GASTRO INTESTINAL

References

Swartz ML. NuLYTELY (PEG 3350, sodium chloride, sodium bicarbonate and potassium chloride for oral solution). Gastroenterol Nurs. 1992 Feb;14(4):200-3. [Accessed 02 Jan. 2026]. Available from:

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Disclaimer

Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Manufacturer details

Name: A)The Madras Pharmaceuticals
Address: A)137-B. Old Mahabalipuram Road, Karapakkam, Chennai - 600 096, INDIA.

Marketer details

Name: Lupin Ltd
Address: 3rd floor Kalpataru Inspire, Off. W E Highway, Santacruz (East), Mumbai 400 055. India

Vendor Details

Country of origin: India
A licensed vendor partner from your nearest location will deliver Pegalup Oral Solution. Once the pharmacy accepts your order, the details of the pharmacy will be shared with you. Acceptance of your order is based on the validity of your doctor's ℞ and the availability of this medicine.

In case of any issues, contact us

Email ID: [email protected]
Phone Number: 0124-4166666
Address: 5th Floor Tower - B of the Presidency Building, 46/4 Mehrauli Gurgaon Road, Sector 14, Gurugram, Haryana-122001, India

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Why we need a prescription?

Provide right medicines

Prescriptions are complex documents. We proof read and recheck at various steps to provide you the right medication in the correct form and dose

In accordance with the law

Most medicines cannot be sold without a valid prescription, as per the Drugs and Cosmetics Act, 1940 and Rules, 1945

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Pegalup Oral Solution

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General Information

Contains

Marketer

Storage

Product introduction

Uses of Pegalup Oral Solution

Benefits of Pegalup Oral Solution

Side effects of Pegalup Oral Solution

How to use Pegalup Oral Solution

How Pegalup Oral Solution works

All substitutes for Pegalup Oral Solution

Pegclear Oral Solution Sugar Free

Smulyte Oral Solution Sugar Free

Pegovag C Oral Solution

Pegxit Oral Solution

Quick tips

Safety advice

Alcohol

Pregnancy

Breast feeding

Driving

Kidney

Liver

Frequently asked questions

What is Pegalup Oral Solution used for?

How should I take Pegalup Oral Solution for colonoscopy preparation?

Can I take my regular medicines with this colon preparation Pegalup Oral Solution?

Who should not take Pegalup Oral Solution?

Can I eat or drink before taking Pegalup Oral Solution for colonoscopy?

How long does Pegalup Oral Solution take to start working?

Can Pegalup Oral Solution cause dehydration or electrolyte imbalance?

What should I do if I vomit after taking the Pegalup Oral Solution?

Fact Box

Habit Forming

Therapeutic Class

References

User feedback

Patients taking Pegalup Oral Solution

Want to know more

Have issue with the content

Disclaimer

Manufacturer details

Marketer details

Vendor Details

In case of any issues, contact us

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