Orthoneuron Plus Tablet

Pregabalin (300mg)+ Methylcobalamin (500mcg)+ Alpha Lipoic Acid (100mg)

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Orthoneuron Plus Tablet is a combination medicine used in the treatment of neuropathic pain. It calms the damaged or overactive nerves by acting on the brain, thereby decreasing the pain sensation. It also helps in the regeneration of damaged nerves in the body.

Written By Dr. Sakshi Jain, MS, BDS,
Reviewed By Dr. Sachin Gupta, MD Pharmacology, MBBS,
Last updated on 25 Nov 2025 | 03:07 PM (IST)

₹81.4 MRP ₹89.239% off

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General Information

Contains

Pregabalin (300mg)+ Methylcobalamin (500mcg)+ Alpha Lipoic Acid (100mg)

Marketer

Vaince Health Pharmaceuticals Ltd

Storage

Store below 30°C

The content is shown in English

Product introduction

Orthoneuron Plus Tablet is advised to take it at the same time each day as this helps to maintain a consistent level of medicine in the body. Take this medicine in the dose and duration advised by your doctor as this is a habit-forming medicine. If you miss a dose of this medicine, take it as soon as you remember. Finish the full course of treatment even if you feel better. It is important that this medication is not stopped suddenly without talking to the doctor.

There is limited data on the side effects of Orthoneuron Plus Tablet. Let your doctor know if you experience any symptoms while taking the medicine. They may be able to suggest ways to treat or manage the side effects.

Your doctor should also know about all other medicines you are taking as many of these may make this medicine less effective or change the way it works. Inform your doctor if you are pregnant, planning pregnancy or breastfeeding.

Uses of Orthoneuron Plus Tablet

Neuropathic pain

Benefits of Orthoneuron Plus Tablet

Neuropathic pain
Neuropathic pain is a type of chronic pain caused by nerve damage, often felt as burning, tingling, or shooting sensations. Orthoneuron Plus Tablet helps relieve this discomfort in multiple ways. It calms overactive nerves to reduce pain signals, supports nerve repair, and protects nerves from further damage by reducing oxidative stress. It helps manage pain and improve nerve function for a better quality of life.

Side effects of Orthoneuron Plus Tablet

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Orthoneuron Plus

Nasopharyngitis (inflammation of the throat and nasal passages)
Increased appetite
Confusion
Disorientation
Abnormality of voluntary movements
Balance disorder (loss of balance)
Erectile dysfunction
Weight gain
Vertigo
Vomiting
Sleepiness
Dizziness
Headache
Constipation
Muscle cramp
Edema (swelling)
Limited data available

How to use Orthoneuron Plus Tablet

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Orthoneuron Plus Tablet may be taken with or without food.

How Orthoneuron Plus Tablet works

Orthoneuron Plus Tablet is a combination of three medicines: Pregabalin, Methylcobalamin and Alpha Lipoic Acid. Pregabalin is an alpha 2 delta ligand which decreases pain by modulating calcium channel activity of the nerve cells. Methylcobalamin is a form of vitamin B which helps in the production of myelin, a substance that protects nerve fibers and rejuvenates damaged nerve cells. Alpha Lipoic Acid is a naturally occurring fatty acid which has a protective effect on brain and nerve tissue. Together, they relieve neuropathic pain (pain from damaged nerves).

Quick tips

You have been prescribed Orthoneuron Plus Tablet for treating and preventing nerve pain.
Inform your doctor if you develop any unusual changes in mood or behavior, new or worsening depression, or suicidal thoughts or behavior.
Do not stop taking the medication suddenly without talking to your doctor.

Safety advice

Alcohol

CAUTION

Alcohol should be used with caution while taking Orthoneuron Plus Tablet.

Pregnancy

CONSULT YOUR DOCTOR

The safety of Orthoneuron Plus Tablet during pregnancy has not been established. There are no adequate and well-controlled studies in pregnant women, and animal data on reproductive toxicity are insufficient. Your doctor will weigh the benefits and any potential risks before prescribing.

Breast feeding

CONSULT YOUR DOCTOR

Orthoneuron Plus Tablet may be unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby. It should be used only if the expected benefit outweighs the potential risk. Please consult your doctor.

Driving

UNSAFE

Orthoneuron Plus Tablet may decrease alertness, affect your vision, or make you feel sleepy and dizzy. Do not drive if these symptoms occur.

Kidney

SAFE IF PRESCRIBED

Orthoneuron Plus Tablet is probably safe to use in patients with kidney disease. Limited data suggest dose adjustment may not be needed.

Liver

SAFE IF PRESCRIBED

Orthoneuron Plus Tablet is probably safe to use in patients with liver disease. Limited data suggest dose adjustment may not be needed.

Frequently asked questions

What is Orthoneuron Plus Tablet?

Orthoneuron Plus Tablet is a combination of three medicines: Pregabalin, Methylcobalamin and Alpha lipoic acid. This medicine is useful in the treatment of nerve pain (neuropathic pain). This medicine calms the damaged or overactive nerves by acting on the brain, thereby decreasing the pain sensation. It also helps in the regeneration of damaged nerves in the body.

Can I stop taking Orthoneuron Plus Tablet when my pain is relieved?

No, you should not stop taking Orthoneuron Plus Tablet even if your pain is relieved. Continue to take it as advised by your doctor. If you suddenly stop taking Orthoneuron Plus Tablet, you may experience withdrawal symptoms such as anxiety, sleeping difficulties, nausea, pain, and sweating. You may need to gradually taper the use of Orthoneuron Plus Tablet before you stop the medication completely.

Can the use of Orthoneuron Plus Tablet cause sleepiness or drowsiness?

Yes, Orthoneuron Plus Tablet may make you feel drowsy or you may suddenly fall asleep during your daily activities. Sometimes, you might not even feel drowsy or have any other warning signs before you suddenly fall asleep. Avoid driving a car, operating machinery, working at heights or participating in potentially dangerous activities until you know how the medicine affects you. Inform your doctor if you experience such episodes while you are taking this medicine.

What if I forget to take Orthoneuron Plus Tablet?

If you forget to take the scheduled dose of Orthoneuron Plus Tablet and it is almost time for your next dose, skip the dose you missed and take your next dose at the scheduled time. Otherwise, take it as soon as you remember, and then go back to taking your medicine as you would normally. Do not take a double dose to make up for the dose you missed because this may increase the risk of unwanted side effect. If you are not sure what to do, ask your doctor about taking Orthoneuron Plus Tablet.

What if I take too much of Orthoneuron Plus Tablet by mistake?

In a situation like this, contact your doctor immediately or seek emergency help at the nearest hospital. Do this even if there are no signs of discomfort or poisoning. You may need urgent medical attention. Symptoms of an overdose may include drowsiness, weakness, unsteadiness while walking, having double visions, slurred speech or diarrhea, confusion, blurred vision, dizziness, body temperature changes (low and high), difficulty in breathing and increased heartbeat.

Will a higher than the recommended dose of Orthoneuron Plus Tablet be more effective?

No, taking a higher than the recommended dose may not be more effective, rather it may increase the chances of having some serious side effects and toxicity. If you experience increased severity of your symptoms, that are not relieved by the recommended doses, please consult your doctor for re-evaluation.

How often should I see the doctor ?

You may need to see your doctor regularly if you have started to take Orthoneuron Plus Tablet. However, if the recommended dosage does not relieve your symptoms or you experience some unwanted side effect that affects your routine activities, consult your doctor.

What are the instructions for the storage and disposal of Orthoneuron Plus Tablet?

Keep this medicine in the packet or the container it came in, tightly closed. Store it according to the instructions mentioned on the pack or label. Dispose of the unused medicine. Make sure it is not consumed by pets, children and other people.

Fact Box

Habit Forming

Therapeutic Class

PAIN ANALGESICS

References

User feedback

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Disclaimer

Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: Vaince Health Pharmaceuticals Ltd
Address: Sai Rasik Residency, 402, A- block, , H.No: 1-90/8, Vitthal Rao Nagar, Madhapur, Hyderabad - 500 081, Telangana State, INDIA

Vendor Details

Country of origin: India

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