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Orgalutran 0.25mg Injection

Ganirelix (0.25mg)
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Orgalutran 0.25mg Injection is an anti-gonadotropin-releasing hormone medicine. It is used in the treatment of infertility in females. It restricts eggs to release directly and prevents premature ovulation.

Written By Dr. Lipika Khurana, PGDHHM, BDS,
Reviewed By Dr. Mekhala Chandra, MD, MBBS,
Last updated on 30 Jul 2026 | 01:01 AM (IST)
₹2077 MRP ₹2233.137% off 
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General Information

The content is shown in English
Orgalutran 0.25mg Injection image
Orgalutran 0.25mg Injection image

Product introduction

Orgalutran 0.25mg Injection is injecting directly into the skin under the supervision of a doctor. Do not self administer the injection. Your doctor or nurse may help you to know the best way to inject the medicine at home. The dose and how often you take it depends on what you are taking it for. Your doctor will decide how much you need to improve your symptoms. You should take this medicine for as long as it is prescribed for you.

The most common side effects of this medicine include injection site reaction (redness, itching, and irritation), vaginal bleeding, and nausea. To overcome irritation at the injection site, use a different injection site every day to inject the medicine. If you experience dizziness, faint, abdominal pain, and vomiting after getting the injection, inform your doctor immediately.

Before taking this medicine, tell your doctor if you have ever had liver or kidney disease or if you are breastfeeding to a baby. Your doctor should also know about all other medicines you are taking as many of these may make this medicine less effective or change the way it works.

Uses of Orgalutran Injection

Benefits of Orgalutran Injection

Female infertility
Female infertility can occur when certain hormonal signals cause the premature release of eggs, reducing the chances of successful fertilization. Orgalutran 0.25mg Injection helps by controlling these signals and preventing early egg release during fertility treatments. This allows eggs to mature properly, improving the chances of successful egg retrieval and pregnancy during assisted reproductive procedures.

Side effects of Orgalutran Injection

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Orgalutran
  • Injection site reaction
  • Headache
  • Nausea
  • Ovarian hyperstimulation syndrome
  • Abdominal pain
  • Vaginal bleeding
  • Fetal death
  • Injection site reactions (pain, swelling, redness)

How to use Orgalutran Injection

Your doctor or nurse will give you this medicine. Kindly do not self administer.

How Orgalutran Injection works

In females undergoing treatment for infertility, sometimes premature ovulation can lead to the release of those eggs which are not ready for fertilization. Orgalutran 0.25mg Injection blocks the action of a natural hormone and prevents premature release of the eggs from the ovary.

Quick tips

  • Orgalutran 0.25mg Injection helps prevent premature ovulation in women undergoing assisted reproduction treatments such as IVF.
  • It is injected under the skin (subcutaneously), preferably of the upper leg.
  • Inform your doctor immediately if you get very dizzy, faint, vomit, or have diarrhea while using this medicine. These could be symptoms of ovarian hyperstimulation syndrome (OHSS).
  • Do not use this medicine if you are already pregnant or breastfeeding.

Safety advice

Alcohol

Alcohol

CONSULT YOUR DOCTOR
It is not known whether it is safe to consume alcohol with Orgalutran 0.25mg Injection. Please consult your doctor.
Pregnancy

Pregnancy

UNSAFE
Orgalutran 0.25mg Injection is highly unsafe during pregnancy. It can cause serious harm to the unborn baby, including birth defects and pregnancy loss. Do not use this medicine if you are pregnant or planning to become pregnant.
Breast feeding

Breast feeding

UNSAFE
Orgalutran 0.25mg Injection is unsafe to use during breastfeeding. Data suggests that the drug may cause toxicity to the baby.
Driving

Driving

CONSULT YOUR DOCTOR
It is not known whether Orgalutran 0.25mg Injection alters the ability to drive. Do not drive if you experience any symptoms that affect your ability to concentrate and react. Please consult your doctor.
Kidney

Kidney

CONSULT YOUR DOCTOR
There is limited data available on the use of Orgalutran 0.25mg Injection in patients with kidney disease. Please consult your doctor.
Use of Orgalutran 0.25mg Injection is not advised in patients with moderate to severe kidney disease patients.
Liver

Liver

CONSULT YOUR DOCTOR
There is limited data available on the use of Orgalutran 0.25mg Injection in patients with liver disease.
Use of Orgalutran 0.25mg Injection is not advised in patients with moderate to severe liver disease patients.

Frequently asked questions

Orgalutran 0.25mg Injection is an injectable preparation, which contains the active substance Ganirelix. It is used in women undergoing certain fertility treatments. It acts by blocking the release of luteinizing hormone (LH), thus preventing the early release of eggs and giving them the time to grow properly.
It is given as an injection, only at a hospital or clinic by a medical healthcare professional. The patient may be monitored regularly for the follicular development. The treatment duration depends on the ovarian response of the patient.
No, Orgalutran 0.25mg Injection does not slow or stop follicle growth
No, Orgalutran 0.25mg Injection does not stop or prevent ovulation. It reduces luteinizing hormone (LH) surge in women suffering from premature ovulation or undergoing a controlled ovarian stimulation for assisted reproduction technique (like IVF).
The most common side effect is local site reaction (redness of skin with or without swelling). You may also experience headache or nausea. However, these effects are temporary. If these persist consult your doctor. In addition, conditions like ovarian hyperstimulation syndrome (OHSS), and multiple births or birth defect may also be associated with the use of this medicine.

Fact Box

Chemical Class

Polypeptides

Habit Forming

No

Therapeutic Class

HORMONES

Action Class

Gonadotropin-releasing hormone (GnRH) Antagonists

References

  1. Masters SB. Hypothalmic & Pituitary Hormones. In: Katzung BG, Masters SB, Trevor AJ, editors. Basic and Clinical Pharmacology. 11th ed. New Delhi, India: Tata McGraw Hill Education Private Limited; 2009. p. 655.
  2. EMEA. Ganirelix. [Accessed 03 Apr. 2019] (online) Available from:
  3. Ganirelix. Ravensburg, Germany: Vetter Pharma-Fertigung GmbH & Co. [Accessed 03 Apr. 2019] (online) Available from:
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User feedback

Once A Day
80%
Once A Week
20%
Female infertility
100%
Average
100%
Abdominal pain
100%
With or without food
100%
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Disclaimer

Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: Organon (India) Ltd
Address: S. No. 120 – 121, Gala No. 1-C, Bldg. No. B-3 City Link Warehouses Complex Mumbai - Nashik Highway, Vadapa, Bhiwandi Dist. Thane 421302, Maharashtra, India

Vendor Details

Country of origin: India
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