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Nisul MR Tablet is a combination of two medicines used in the treatment of pain due to muscle spasm. It improves the movement of muscles and provides relief from pain and discomfort associated with muscle spasms.

Written By Dr. Lipika Khurana, PGDHHM, BDS,
Reviewed By Dr. Rajeev Sharma, MBA, MBBS,
Last updated on 07 Apr 2026 | 02:54 PM (IST)
₹5.1 MRP ₹5.639% off 
As per Ministry of Health and Family Welfare
Gurgaon
 
 
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General Information

Contains

Nimesulide (100mg)+ Tizanidine (2mg)

Marketer

Intas Pharmaceuticals Ltd

Storage

Store below 30°C
The content is shown in English
Nisul MR Tablet image
Nisul MR Tablet image

Product introduction

Nisul MR Tablet should be taken with food. This will prevent you from getting an upset stomach. You should take it regularly as advised by your doctor. Do not take more or use it for a longer duration than recommended by your doctor.

Using this medicine can cause some common side effects such as nausea, vomiting, diarrhea, stomach upset, sleepiness, weakness, and increased liver enzymes. If any of these side effects bother you or do not go away with time, you should let your doctor know. Your doctor may help with ways to reduce or prevent these side effects.

The medicine may not be suitable for everybody. Before taking it, let your doctor know if you have any problems with your heart, kidneys, or liver. To make sure it is safe for you, let your doctor also know all the other medicines you are taking. Pregnant and breastfeeding mothers should first consult their doctors before using the medicine.


Note: As per the Ministry of Health and Family Welfare, Nisul MR Tablet is banned for children under 12 years of age.

Uses of NISUL MR Tablet

  • Pain due to muscle spasm

Benefits of NISUL MR Tablet

Pain due to muscle spasm
Muscle spasms cause sudden, involuntary contractions that can lead to pain and restricted movement. Nisul MR Tablet helps relieve such discomfort effectively, reducing inflammation and pain, and relaxing tight muscles. This medicine improves mobility, eases stiffness, and enhances comfort in daily activities.

Side effects of NISUL MR Tablet

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of NISUL MR
  • Nausea
  • Dryness in mouth
  • Vomiting
  • Diarrhea
  • Weakness
  • Sleepiness
  • Increased liver enzymes

How to use NISUL MR Tablet

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Nisul MR Tablet should be taken with or after food.

How NISUL MR Tablet works

Nisul MR Tablet is a combination of two medicines: Nimesulide and Tizanidine which relieve muscle pain. Nimesulide is a non-steroidal anti-inflammatory drug (NSAID) which works by blocking the release of certain chemical messengers that cause pain and inflammation (redness and swelling). Tizanidine is a muscle relaxant. It works by acting on the centers in the brain and spinal cord to relieve the muscle stiffness or spasm.

Quick tips

  • You have been prescribed Nisul MR Tablet to get relief from pain and stiffness in the muscles.
  • Take it with food or milk to prevent an upset stomach.
  • You may see results within 1.5 to 2 hours after taking Nisul MR Tablet. Take it exactly as advised by your doctor.
  • Avoid consuming alcohol while taking Nisul MR Tablet as it can increase your risk of stomach problems.
  • Inform your doctor if you have a history of seizures.
  • Along with taking Nisul MR Tablet, your doctor might advise you to undergo physiotherapy to get relief from muscle pain.

Safety advice

Alcohol

Alcohol

CAUTION
Alcohol should be used with caution while taking Nisul MR Tablet.
Pregnancy

Pregnancy

UNSAFE
Nisul MR Tablet is highly unsafe during pregnancy. It can cause serious harm to the unborn baby, including birth defects and pregnancy loss. Do not use this medicine if you are pregnant or planning to become pregnant.
Breast feeding

Breast feeding

CONSULT YOUR DOCTOR
Nisul MR Tablet may be unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby. It should be used only if the expected benefit outweighs the potential risk. Please consult your doctor.
Driving

Driving

UNSAFE
Nisul MR Tablet may decrease alertness, affect your vision, or make you feel sleepy and dizzy. Do not drive if these symptoms occur.
Kidney

Kidney

CAUTION
Nisul MR Tablet should be used with caution in patients with severe kidney disease. Dose adjustment may be needed.
Liver

Liver

UNSAFE
Nisul MR Tablet is unsafe to use in patients with liver disease and should be avoided.

Fact Box

Habit Forming

No

Therapeutic Class

PAIN ANALGESICS

References

  1. MedIndia. Nimesulide+Tizanidine. [Accessed on 25 Apr. 2019] (online) Available from:
  2. European Medicne Agency. Nimesulide; 2004. [Accessed 02 Apr. 2019] (online) Available from:
  3. Tizanidine. Ardsley, New York: Acorda Therapeutics Inc.; 1996 [revised 2013]. [Accessed 02 Apr. 20191] (online) Available from:
  4. ScienceDirect. Nimesulide. [Accessed 02 Apr. 2019] (online) Available from:
  5. Tizanidine. Hawthorne, New York: Acorda Therapeutics Inc.; 2006]. [Accessed 02 Apr. 2019] (online) Available from:
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User feedback

Twice A Day
71%
Once A Day
29%
Headache
100%
Excellent
67%
Average
33%
No Side Effect
100%
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Disclaimer

Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: Intas Pharmaceuticals Ltd
Address: Chinubhai Centre, Off. Nehru Bridge, Ashram Road, Ahmedabad - 380009. Gujarat. India.

Vendor Details

Country of origin: India

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