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Nirmacom Combipack Tablet is intended to treat mild-to-moderate coronavirus disease(COVID-19) in adults and children aged 12 years and older weighing at least 40 kg with a positive COVID-19 test and at risk of progression to severe disease. It reduces the ability of the coronavirus to multiply in the body.

Written By Dr. Subita Alagh, BDS,
Reviewed By Dr. Rajeev Sharma, MBA, MBBS,
Last updated on 31 Mar 2026 | 02:32 PM (IST)
₹831 MRP ₹918.7510% off 
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General Information

Contains

Nirmatrelvir (150mg)+ Ritonavir (100mg)

Marketer

Hetero Healthcare Limited
The content is shown in English
Nirmacom Combipack Tablet image
Nirmacom Combipack Tablet image

Product introduction

Nirmacom Combipack Tablet works by stopping the virus from making copies of itself from being effective, it needs to be started within five days of developing COVID symptoms. It is meant for oral intake regardless of the meals. Stick to the dose and duration as prescribed by the doctor. Do not withdraw it abruptly, even if the symptoms improve within the initial few days of the ingestion and report if it worsens after five days. Complete the medicine course as prescribed. Never self-medicate at home based on symptoms without a confirmatory covid-19 test and the doctor’s prescription.

Some transient side-effects of Nirmacom Combipack Tablet include dysgeusia (altered taste), diarrhea, hypertension, myalgia (muscle pain) and vomiting. Consult the doctor right away in case of worrisome episodes.

Inform the doctor about your complete medical history, including the use of concomitant medicines, allergies, pregnancy, history of liver disease including hepatitis C, immunocompromised conditions such as Human Immunodeficiency Virus(HIV), nursing, surgery, neurological, cardiovascular,  or any other underlying medical condition. This will help the doctor formulate the treatment plan in a better way.

Tell the doctor if using combined hormonal contraceptives as Nirmacom Combipack Tablet may affect how the birth control pills work. Females with reproductive potential should practice other effective alternative contraceptive methods. Discuss with the doctor the use of the right contraceptive methods while taking this medication. Additionally, if taking ritonavir-containing medicines for hepatitis C, or HIV, continue taking Nirmacom Combipack Tablet as prescribed.

Uses of Nirmacom Kit

  • Treatment of Coronavirus disease (COVID-19)

Benefits of Nirmacom Kit

Treatment of Coronavirus disease (COVID-19)
Nirmacom Combipack Tablet is most helpful for people with mild COVID symptoms who are at high risk of developing severe disease. Nirmatrelvir, an antiviral medicine, stops the virus from spreading into the body, and ritonavir, a booster, increases the availability of nirmatrelvir in the body to maximize the effectiveness of this combination medicine.

Side effects of Nirmacom Kit

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Nirmacom
  • Taste change
  • Diarrhea
  • Vomiting
  • High blood pressure
  • Muscle pain

How to use Nirmacom Kit

Take this medicine in the dose and duration as advised by your doctor. Check the label before use. Nirmacom Combipack Tablet may be taken with or without food.

How Nirmacom Kit works

Nirmacom Combipack Tablet is a combination of two drugs, nirmatrelvir, a SARS-CoV-2-3CL protease inhibitor and ritonavir, the HIV antiretroviral. Nirmatrelvir blocks the action of SARS-CoV-2-3CL protease enzyme, which is essential for replication of the virus. On the other hand, ritonavir prevents the breakdown of nirmatrelvir.

Quick tips

  • Do not give Nirmacom Combipack Tablet to children below 12 years of age or weighing less than 40 kg.
  • Seek immediate medical attention if you see signs of allergic reactions like rash, difficulty swallowing or breathing, or swelling of the eyelids, lips, face, throat, or tongue.
  • Inform your doctor if you have liver or kidney disease before starting the treatment.
  • It is advisable to use non-hormonal contraceptive methods during the 5 days of Nirmacom Combipack Tablet treatment and until one menstrual cycle after stopping the drug.
  • Do not stop taking Nirmacom Combipack Tablet without talking to your doctor first, as it will protect you from becoming severely ill from COVID-19.
  • Even after the treatment, continue practicing COVID-appropriate behavior such as wearing a mask, social distancing, and frequent handwashing.

Safety advice

Alcohol

Alcohol

CONSULT YOUR DOCTOR
It is not known whether it is safe to consume alcohol with Nirmacom Combipack Tablet. Please consult your doctor.
Pregnancy

Pregnancy

CONSULT YOUR DOCTOR
Information regarding the use of Nirmacom Combipack Tablet during pregnancy is not available. Please consult your doctor.
Breast feeding

Breast feeding

CONSULT YOUR DOCTOR
Information regarding the use of Nirmacom Combipack Tablet during breastfeeding is not available. Please consult your doctor.
Driving

Driving

CONSULT YOUR DOCTOR
It is not known whether Nirmacom Combipack Tablet alters the ability to drive. Do not drive if you experience any symptoms that affect your ability to concentrate and react. Please consult your doctor.
Kidney

Kidney

CAUTION
Nirmacom Combipack Tablet should be used with caution in patients with kidney disease. Dose adjustment may be needed.
The appropriate dosage for patients with severe renal impairment has not been determined. Until more data are available, Nirmacom Combipack Tablet is not recommended in patients with severe renal impairment.
Liver

Liver

SAFE IF PRESCRIBED
Nirmacom Combipack Tablet is safe to use in patients with liver disease. No dose adjustment is recommended.
No data are available regarding the use of Nirmacom Combipack Tablet in patients with severe hepatic impairment; therefore, Nirmacom Combipack Tablet is not recommended for use in patients with severe hepatic impairment.

Frequently asked questions

Yes, taking Nirmacom Combipack Tablet may make the medicines used to treat HIV less effective. It is advisable to take Nirmacom Combipack Tablet only if prescribed by a doctor. Do not self-medicate.
No. Avoid taking any other medicines while taking Nirmacom Combipack Tablet, unless otherwise prescribed by your doctor. This is because certain medicines may interact with Nirmacom Combipack Tablet or affect its effectiveness. Ask your doctor before taking any medicine.
Yes. Always take Nirmacom Combipack Tablet in the prescribed schedule which is of 5 days. Skipping your dose may affect viral clearance and worsen your condition. Also, maintain isolation and take all the preventive measures like washing your hands, wearing a mask, using a hand sanitizer regularly, etc., to minimize the risk of viral transmission.
If you miss a dose of Nirmacom Combipack Tablet within 8 hours of the usual time, take it as soon as possible and resume the normal dosing schedule. If it is more than 8 hours, do not take the missed dose and instead take the next schedules dose at the regular time. Do not double the dose to make up for a missed dose.
Yes. Few patients may be allergic to Nirmacom Combipack Tablet, just like any other medicine. If you notice any signs like rashes, hives or any other skin reactions, difficulty in breathing or swallowing, any sudden swelling like swelling of the face, lips, tongue, tightness of the throat or hoarseness of voice, it may be due to an allergic reaction. Inform your doctor immediately or rush to a nearby hospital/doctor to avoid any mishap.
No. Nirmacom Combipack Tablet is not safe for children as its effects have not been studied in children or those below 18 years of age.
Yes. Nirmacom Combipack Tablet contains lactose, a form of sugar. If you are allergic to lactose or sugar, please inform your doctor before taking Nirmacom Combipack Tablet.

Fact Box

Habit Forming

No

Therapeutic Class

ANTI INFECTIVES

References

  1. Pfizer. Press Release [June 14, 2022]. Pfizer Reports Additional Data on PAXLOVID™ Supporting Upcoming New Drug Application Submission to U.S. FDA. [Accessed 11 Sept. 2022] (online) Available from:
  2. Nirmatrelvir+Ritonavir [PAXLOVID]. Patient Eligibility Screening Checklist Tool for Prescribers. [Accessed 11 Sept. 2022] (online) Available from:
  3. Nirmatrelvir+Ritonavir [EMC SmPC]. Kent, UK: Pfizer Limited; 2022. [Accessed 11 Sept. 2022] (online) Available from
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Disclaimer

Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: Hetero Healthcare Limited
Address: S.no: 80-84, Melange towers, PatrikaNagar,Madhapur,Hyderabad. Telangana-500081.

Vendor Details

Country of origin: India

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