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10 Jul 2020 | 06:59 PM (IST)
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Nifecaine Cream

Prescription Required
Store at room temperature (10-30°C)


Nifecaine Cream is a combination of two medicines used in the treatment of anal fissures (tear in the lining of the anus). It relieves the pain, swelling, itching, and discomfort associated with the passing of stools in people who suffer from problems in the anal area.

Nifecaine Cream relaxes the blood vessels in the anus thus helping in the healing of anal fissures. It should be used in the dose and duration as directed by your doctor. Do not stop using it suddenly without talking to your doctor, as it may lead to worsening of your condition.

Before applying this medicine clean and dry the affected area. Make sure to wash your hands thoroughly before and after applying this medicine. Avoid getting this medicine into your eyes, nose, or mouth. If accidental exposure occurs, wash your eyes with water and seek immediate medical attention.

This medicine is generally well tolerated with minimal or no side effects. However, slight anal irritation may occur as a side effect of this medicine. This is temporary and usually resolves on its own in some time. Please consult your doctor if it does not resolve or persists for a longer duration. Inform your doctor immediately if you notice worsening of the infection or if you develop increased redness and irritation.

Uses of Nifecaine Rectal Cream

Benefits of Nifecaine Rectal Cream

In Anal fissure

Nifecaine Cream is used to relieve pain, irritation, or itching caused by anal fissures (tear in the lining of the anus). It relaxes the blood vessels thereby decreasing the pressure in the anal tissues. Use it in the dose and duration as advised by your doctor.

Side effects of Nifecaine Rectal Cream

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Nifecaine

  • Anal irritation

How to use Nifecaine Rectal Cream

This medicine is for external use only. Use it in the dose and duration as advised by your doctor.

How Nifecaine Rectal Cream works

Nifecaine Cream is a combination of two medicines: Lidocaine and Nifedipine. Lidocaine is a local anesthetic. It works by blocking pain signals from the nerves to brain which decreases pain sensation. Nifedipine is a calcium channel blocker (CCB). It works in anal fissure by blocking the action of calcium on blood vessels of anus.

Safety Advice

No interaction found/established
Nifecaine Cream may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
Nifecaine Cream is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby.
No interaction found/established
Nifecaine Cream should be used with caution in patients with severe kidney disease. Dose adjustment of Nifecaine Cream may be needed. Please consult your doctor.
Nifecaine Cream should be used with caution in patients with liver disease. Dose adjustment of Nifecaine Cream may be needed. Please consult your doctor.

Alternate Brands

For informational purposes only. Consult a doctor before taking any medicines.
Nifecaine Cream
₹4.66/gm of Rectal Cream
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Anozest Cream
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₹3.97/gm of Rectal Cream
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Anorelief Cream
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₹4.67/gm of Rectal Cream
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Escot Cream
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₹5.3/gm of Rectal Cream
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₹10/gm of Rectal Cream
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Quick Tips

  • It is for administration into the rectum (back passage). It must not be taken by mouth.
  • Tips to treat constipation caused by anal fissure:
    • Drink plenty of fluids to stay hydrated.
    • Have fiber-rich food such as whole grains, oatmeal, and citrus fruits.
    • Exercise regularly.
    • Do not sit on the toilet for too long.
    • Do not ignore your urge to go to the washroom.
  • Use the applicator provided to insert a measured dose of cream into your back passage.
  • Avoid getting it in the eyes, mouth or nose. Rinse with cold water if you accidentally get it in these areas.

Fact Box

Habit Forming
Therapeutic Class

Patient Concerns

I occasionally find blood in my stool.
Dr. Sfurti Mann
Internal Medicine
May be anal fissure, get yourself examined by a surgeon.
Fissure and fistula of anal region Fissure and fistula of anal and rectal region
Dr. Pushkar Mani
refer to surgeon again
Do you have any questions related to Nifecaine Cream ?

User Feedback


Q. Does Nifecaine Cream cure anal fissures?

No, it does not cure fissures but Nifecaine Cream reduces inflammation of mucous membrane and skin. It reduces irritation, alleviates pain and itching, thus providing symptomatic relief.

Q. Why is my fissure not healing?

Fissures usually heal within a few weeks. But if they are not, this is because the oxygen supply, carried by the blood, to these fissures is poor which further slows down the healing process. As a result, these fissures fail to heal and continue to get worse. You should consult a doctor immediately if you have been facing issues for a duration longer than a few weeks.

Q. What should I eat and avoid in fissure?

You must take a fiber-rich diet such as vegetables, fresh fruits and whole grains if you have fissures. Drink plenty of water and avoid taking alcohol. This will ensure that your stools are soft and easy to pass. You may also take laxatives or fiber supplements if you are facing issues with digestion. Your doctor will suggest ways to avoid constipation and thereby promote healing of fissures.

Q. Can spicy food cause fissures?

No. Spicy foods do not cause fissures. But, they can irritate the fissures and worsen your symptoms. Therefore, it is advised that you avoid taking spicy foods if you are facing issues with your fissures.

Q. How do you use Nifecaine Cream cream?

Follow your doctor’s instructions before using Nifecaine Cream. Apply a small amount of the ointment to the affected rectal area as directed. If this is to be used inside the rectum, attach the rectal applicator onto the tube. Insert the applicator gently and to full extent into the rectum. Gently squeeze the tube to deliver the medication while withdrawing it.

Q. How long does it take to heal fissures?

Fissures usually heal within a few weeks. But, if they persist for longer than 4 to 6 weeks, they are termed as chronic fissures. Please consult your doctor without any delay if you have been noticing fissures for longer than 4 weeks.

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1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover all possible side effects, drug interactions or warnings or alerts. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.


  1. Perrotti P, Dominici P, Grossi E, et al. Pharmacokinetics of Anorectal Nifedipine and Lidocaine (Lignocaine) Ointment Following Haemorrhoidectomy: An Open-Label, Single-Dose, Phase IV Clinical Study. Clin Drug Investig. 2009;29(4):243-56. [Accessed 17 Feb. 2020] (online) Available from:External Link
  2. Perrotti P, Dominici P, Grossi E, et al. Topical nifedipine with lidocaine ointment versus active control for pain after hemorrhoidectomy: results of a multicentre, prospective, randomized, double-blind study. Can J Surg. 2010;53(1):17-24. [Accessed 17 Feb. 2020] (online) Available from:External Link

Manufacturer/Marketer Address

Troikaa Pharmaceuticals Ltd., Registered Office: , 'Commerce House - 1', Satya Marg, Bodakdev, Ahmedabad-380 054. Gujarat, India.
Best Price
MRP139.7  Get 15% OFF
Inclusive of all taxes
Best price is valid on orders above ₹499
30 gm in 1 tube


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