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Composition for NIFECAINE

Lidocaine(1.5% w/w),Nifedipine(0.3% w/w)

food interaction for NIFECAINE

alcohol interaction for NIFECAINE

pregnancy interaction for NIFECAINE

lactation interaction for NIFECAINE

Avoid Nifecaine cream with grapefruit juice.
Interaction with alcohol is unknown. Please consult your doctor.
Nifecaine cream may be unsafe to use during pregnancy.
Either animal studies have shown adverse effect on fetus and there are no human studies or studies in human and animals are not available. It should be given only if potential benefits justifies risk to the fetus. Please consult your doctor.
Nifecaine cream is probably safe to use during breastfeeding. Please consult your doctor.


Lidocaine(1.5% w/w)


It is used to numb an area of body for temporary relief of pain caused by recurrent mouth ulcers, denture irritation, anal or rectal problems. It is also used before minor surgeries as local anesthetic.

How it works

Lidocaine belongs to a class of medications called local anesthetics. It works by stopping the sensation of pain by acting on peripheral nerves in the body.

Common side effects

Hormone imbalance, Allergic reaction, Slow growth in children and teenagers, Rash, Itching, Urticaria
Nifedipine(0.3% w/w)


Nifedipine is used to treat high blood pressure and to control angina ( chest pain).

How it works

Nifedipine belongs to a category of drugs called as calcium channel blockers. It acts by widening the blood vessels to allow easy blood flow, which lowers the blood pressure and reduces chest pain.

Common side effects

Nausea, Allergic reaction, Swelling of tongue, Ankle swelling, Limb swelling, Chest pain, Constipation, Cough, Decreased sexual function, Dizziness, Difficulty in swalloing, Shortness of breath, Eye swelling, Facial swelling, Lip swelling, Fainting, Headache, Heartburn, Muscle cramp, Skin rash, Tachycardia, Yellow discoloration of skin, Yellow discoloration of eye


No substitutes found

Expert advice for NIFECAINE

  • Do not use more quantity of lidocaine than recommended as this may culminate into excessive absorption of drug causing serious side effects, such as fits.
  • Do not use this medicine in case of open wounds or damaged areas (especially in mouth) as this may result into excessive absorption of active ingredient.
  • Do not give this medicine to children under the age of 12 years.
  • Do not apply more frequently than every 3 hours.
  • Tell your doctor or pharmacist if you are taking, have recently taken, or might take any other medicines.
  • Consult your doctor before taking lignocaine if you are pregnant or lactating.

Frequently asked questions for NIFECAINE


Q. Are lidocaine, lignocaine, and xylocaine the same things?
Yes. These are all the other names for an amide type local anesthetic, lidocaine. Lidocaine acts by stopping the sensation of pain by acting on peripheral nerves in the body. It is generally available as topical gel formulation however injections are also available. 
Q. Is lidocaine an opiate/ narcotic/ steroid drug/ omega 3/ nitrates/ cholesterol/ contain codeine/ sulpha?
No. Lidocaine (Lox) is an amide type local anesthetic used to relieve pain topically or by an injection. It is not an opiate narcotic, steroid, omega 3, nitrates, and cholesterol. It does not contain codeine or sulpha.
Q. Is lidocaine and Lox2 safe?
Lidocaine (also available as Lox2) is safe for usage when applied topically as instructed by a doctor. Lidocaine in injectable formulation must not be self-medicated. Always follow the doctor’s advice regarding its use.
Q. Is lidocaine a controlled substance / addictive?
No. Lidocaine is not controlled substance or addictive.
Q. Is lidocaine available over the counter?
No. It is categorized as schedule H drug in India and it is available only by prescription given by your doctor
Q. Is Lox (lidocaine) safe to eat?
No. Lidocaine should never be taken by mouth.
Q. Does lignocaine cause swelling/ drowsiness/ makes you high/ weight gain/ kill sperm?
Lignocaine is not known to cause swelling/ drowsiness/ makes you high/ weight gain/ kill sperm. However, if you experience such side effects consult your doctor.
Q. Can I take Advil/ ibuprofen/paracetamol/ Tylenol/ Vicodin/ Nyquil with lidocaine?
Lignocaine can be taken with above mentioned drugs. Consult your doctor regarding its use.


Q. Is nifedipine safe?
Nifedipine is relatively safe if used as recommended. In case of any side-effects, consult your doctor.
Q. Is Nifedipine a nitrate/beta-blocker/ACE inhibitor/tocolytic?
No. Nifedipine is not a nitrate, beta-blocker, or an ACE inhibitor. It is a calcium channel blocker.
Q. What is Calcigard/Nicardia/Dipin used for?
Calcigard, Nicardia, Dipin are examples of a few brands containing nifedipine and used for treating high blood pressure, chest-pain and Reynaud’s phenomenon.
Q. Can I take aspirin/Tylenol/Benadryl/Viagra/ Tums/Sudafed with nifedipine?
Nifedipine can be taken with Tylenol (paracetamol), Sudafed (pseudoephedrine) and Benadryl. Taking Viagra (sildenafil) may increase the blood pressure lowering effect of nifedipine. Taking aspirin may increase the blood pressure. Tums (calcium carbonate) may decrease the effect of nifedipine. Consult your doctor before use.
Q. Does nifedipine cause migraine/constipation/insomnia/bradycardia/cough/weight gain/urination/changes in heart rate?
Nifedipine may cause migraine, constipation, insomnia or bardycardia (slow heart rate). There is no evidence of nifedipine causing cough or weight changes. If you notice such symptoms, please consult your doctor.
Q. Is nifedipine a narcotic or tocolytic?
No. Nifedipine is a non-narcotic/ uncontrolled/nonaddictive drug. Nifedipine is used as tocolytic (to delay preterm birth).


Content on this page was last updated on 05 January, 2015, by Dr. Varun Gupta (MD Pharmacology)