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Natrilam 5 Tablet SR is a medicine used to treat hypertension (high blood pressure). It is a combination of two medicines that effectively controls blood pressure when a single medication is not effective.

Written By Dr. Subita Alagh, BDS,
Reviewed By Dr. Sachin Gupta, MD Pharmacology, MBBS,
Last updated on 25 Nov 2025 | 03:07 PM (IST)
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Natrilam 5 Tablet SR image
Natrilam 5 Tablet SR image
Natrilam 5 Tablet SR image
Natrilam 5 Tablet SR image
Natrilam 5 Tablet SR image
Natrilam 5 Tablet SR image

Product introduction

Natrilam 5 Tablet SR should be taken with food preferably in the morning to avoid frequent urination at night. Keep taking it for as long as advised by your doctor. Even if you feel well, do not stop this medicine on your own because high blood pressure often has no symptoms. If you stop taking it, your condition may get worse. Keeping active with regular exercise, reducing your weight and eating a healthy diet will also help control your blood pressure. Follow your doctor’s advice while taking this medicine.

Glucose intolerance, ankle swelling, headache, and decreased potassium level are some common side effects of this medicine. Consult your doctor If any of these bother you, or get worse, or do not go away.  Drink plenty of fluids while taking medicine to overcome muscle weakness, dry mouth, and extreme thirst. Dizziness or headache may occur due to low blood pressure, hence rise slowly from sitting position or avoid driving.

Before taking it, let your doctor know if you have any liver or kidney problems. Pregnant or breastfeeding women should also consult their doctor for advice before taking this medicine. You also need to tell your doctor what other medicines you are taking especially those used to treat high blood pressure or heart conditions. You should have your blood pressure, kidney function, level of electrolytes, and blood sugar level checked regularly to make sure that this medicine is working properly.

Uses of Natrilam Tablet SR

Benefits of Natrilam Tablet SR

Hypertension (high blood pressure)
Hypertension (high blood pressure) is a long-term condition in which the force of blood against the artery walls is too high, increasing the risk of heart disease, stroke, and kidney problems. Natrilam 5 Tablet SR is used to help lower blood pressure effectively. It works by helping the blood vessels relax and remove excess fluid from the body, thereby reducing strain on the heart and lowering the risk of complications.

Side effects of Natrilam Tablet SR

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Natrilam
  • Dyspepsia
  • Diarrhea
  • Sleepiness
  • Ankle swelling
  • Headache
  • Flushing (sense of warmth in the face, ears, neck and trunk)
  • Nausea
  • Palpitations
  • Decreased potassium level in blood
  • Dizziness
  • Edema (swelling)
  • Visual impairment
  • Breathlessness
  • Constipation
  • Muscle spasm
  • Fatigue
  • Weakness

How to use Natrilam Tablet SR

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Natrilam 5 Tablet SR should be taken with or after food.

How Natrilam Tablet SR works

Amlodipine and indapamide which lower blood pressure effectively. Amlodipine is a calcium channel blocker which relaxes blood vessels and makes the heart more efficient at pumping blood throughout the body. Indapamide is a diuretic which removes extra water and certain electrolytes from the body by increasing the amount of urine produced. Over time it also works by relaxing blood vessels and improving blood flow.

All substitutes for Natrilam 5 Tablet SR

For information purposes only. Consult a doctor before taking any medicine.

Quick tips

  • Natrilam 5 Tablet SR helps in the treatment of high blood pressure.
  • It also lowers your risk of stroke and heart attack.
  • Take it in the morning with breakfast to avoid getting up at night to urinate.
  • It may cause dizziness or sleepiness. Don't drive or do anything requiring concentration until you know how it affects you.
  • It may cause you to feel lightheaded or weak especially when you stand up (orthostatic hypotension).  Rise slowly if you have been sitting or lying down.
  • It may cause dehydration. Drink plenty of fluids and Inform your doctor if you develop extreme thirst, muscle weakness or very dry mouth.
  • Your doctor may regularly monitor your blood pressure, kidney function and the levels of salts such as potassium in your blood while you are taking this medicine.
  • Natrilam 5 Tablet SR helps in the treatment of high blood pressure.
  • It also lowers your risk of stroke and heart attack.
  • Take it in the morning with breakfast to avoid getting up at night to urinate.
  • It may cause dizziness or sleepiness. Don't drive or do anything requiring concentration until you know how it affects you.
  • It may cause you to feel lightheaded or weak especially when you stand up (orthostatic hypotension).  Rise slowly if you have been sitting or lying down.
  • It may cause dehydration. Drink plenty of fluids and Inform your doctor if you develop extreme thirst, muscle weakness or very dry mouth.
  • Your doctor may regularly monitor your blood pressure, kidney function and the levels of salts such as potassium in your blood while you are taking this medicine.

Safety advice

Alcohol

Alcohol

UNSAFE
It is unsafe to consume alcohol with Natrilam 5 Tablet SR
Pregnancy

Pregnancy

CONSULT YOUR DOCTOR
The safety of Natrilam 5 Tablet SR during pregnancy has not been established. There are no adequate and well-controlled studies in pregnant women, and animal data on reproductive toxicity are insufficient. Your doctor will weigh the benefits and any potential risks before prescribing.
Breast feeding

Breast feeding

CONSULT YOUR DOCTOR
Natrilam 5 Tablet SR may be unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby. It should be used only if the expected benefit outweighs the potential risk. Please consult your doctor.
Driving

Driving

UNSAFE
Natrilam 5 Tablet SR may cause side effects that could affect your ability to drive.
Natrilam 5 Tablet SR may cause side effects such as dizziness, headaches, nausea or tiredness, all of which could affect your ability to concentrate and drive.
Kidney

Kidney

CAUTION
Natrilam 5 Tablet SR should be used with caution in patients with severe kidney disease. Dose adjustment may be needed.
Liver

Liver

CAUTION
Natrilam 5 Tablet SR should be used with caution in patients with liver disease. Dose adjustment may be needed.

Frequently asked questions

Natrilam 5 Tablet SR is used to treat high blood pressure (hypertension) in adults. Amlodipine in Natrilam 5 Tablet SR relaxes blood vessels to improve blood flow, while indapamide in Natrilam 5 Tablet SR helps the body remove excess fluid and reduces blood pressure.
Individuals should not take Natrilam 5 Tablet SR if they are allergic to amlodipine, indapamide, or if they have severe liver problems, low potassium levels, or untreated heart failure.
Yes, Natrilam 5 Tablet SR can sometimes cause a drop in blood pressure, leading to dizziness or fainting. This is more likely if you are dehydrated or taking other medicines for high blood pressure.
Caution is needed if you have kidney disease, as Natrilam 5 Tablet SR can affect kidney function. Your doctor may monitor kidney tests during treatment.
Yes, Natrilam 5 Tablet SR can lower potassium or sodium levels in the blood. This can cause muscle weakness, cramps, or irregular heartbeat, so regular blood tests may be needed.
Natrilam 5 Tablet SR may cause fluid retention in the legs or ankles. If swelling is severe or sudden, inform your doctor.
People with certain heart conditions, such as unstable angina or a recent heart attack, need close monitoring, as Natrilam 5 Tablet SR can sometimes worsen chest pain in the early stages of treatment.
Yes, Natrilam 5 Tablet SR can make your skin more sensitive to sunlight, increasing the risk of sunburn. Use sun protection while taking this medicine.
Yes, Natrilam 5 Tablet SR can raise uric acid levels in the blood, which may trigger gout in some people.
Rarely, Natrilam 5 Tablet SR can cause liver-related side effects. Seek medical help if you develop yellowing of the skin or eyes, dark urine, or unexplained fatigue.
While taking Natrilam 5 Tablet SR, regular check-ups help track your blood pressure, kidney function, and blood electrolyte levels to ensure the medicine works safely and effectively.

Fact Box

Habit Forming

No

Therapeutic Class

CARDIAC

Related lab tests

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User feedback

Once A Day
100%
Hypertension (high blood pressure)
95%
Others
2%
Angina (heart-related chest pain)
2%
Average
49%
Excellent
41%
Poor
10%
No Side Effect
70%
Headache
20%
Sleepiness
10%
With food
80%
Empty stomach
10%
With or without food
10%
Expensive
47%
Average
30%
Not Expensive
23%
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Disclaimer

Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: Servier India Private Limited
Address: 1703, 17th Floor, Parinee Crescenzo, 'B' Wing, Plot No. 38 & 39 G Block behind MCA, MKC Bandra East, Mumbai 40051

Vendor Details

Country of origin: India
A licensed vendor partner from your nearest location will deliver Natrilam 5 Tablet SR. Once the pharmacy accepts your order, the details of the pharmacy will be shared with you. Acceptance of your order is based on the validity of your doctor's ℞ and the availability of this medicine.

In case of any issues, contact us

Email ID: [email protected]
Phone Number: 0124-4166666
Address: 5th Floor Tower - B of the Presidency Building, 46/4 Mehrauli Gurgaon Road, Sector 14, Gurugram, Haryana-122001, India
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