Natfost 500mg Injection

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Natco Pharma Ltd

Composition for Natfost 500mg Injection

iconPrescription Required

Primarily used for

Dryness in the mouth after radio therapy of head and neck cancer
93.35
1 Injection in 1 vial
SOLD OUT

Medicine Overview of Natfost Injection

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Uses of Natfost Injection

Natfost 500mg Injection is used to prevent dryness in the mouth after radio therapy of head and neck cancer
It is also used to reduce the harmful effect of chemotherapy on the kidneys during treatment with cisplatin.
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Side effects of Natfost Injection

Common

Nausea, Vomiting, Decreased blood pressure, Hiccup, Sleepiness, Dizziness, Flushing (sense of warmth in the face, ears, neck and trunk), Fever, Chills.

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How to use Natfost Injection

Your doctor or nurse will give you this medicine. Kindly do not self administer.

How Natfost Injection works

Natfost 500mg injection works by removing free radical, harmful elements produced by cisplatin (a medicine used to treat cancer) or radiation therapy in tissues.

In Depth Information on Natfost Injection

Expert advice for Natfost Injection

  • Inform your doctor if you suffer from cardiovascular or cerebrovascular conditions such as ischemic heart disease (chest pain, discomfort or frank heart attack), arrhythmias (irregular heartbeats), heart failure, or have a history of stroke or transient ischemic attacks (mini stroke).
  • You need to be adequately hydrated prior to the amifostine infusion.
  • Frequent monitoring of blood pressure is required during infusion and use of antihypertensive drugs 24 hr prior to start of amifostine infusion should be avoided.
  • Tell your doctor if you are or planning to become pregnant or are breastfeeding.
  • Inform your doctor immediately if you develop any skin reaction or reactions in and around the mouth, any time following amifostine administration. 
  • Amifostine is not recommended for use in elderly.
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Warnings
Special precautions for Natfost 500mg Injection
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Alcohol
Interaction with alcohol is unknown. Please consult your doctor.
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Pregnancy
WEIGH RISKS VS BENEFITS
Natfost 500mg Injection may be unsafe to use during pregnancy.

Animal studies have shown adverse effects on the foetus, however, there are limited human studies. The benefits from use in pregnant women may be acceptable despite the risk. Please consult your doctor.
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Lactation
Natfost 500mg Injection is probably safe to use during lacta
tion. Limited human data suggests that the drug does not represent a significant risk to the baby.
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Driving
It is not known whether Natfost 500mg Injection alters the a
bility to drive. Do not drive if you experience any symptoms that affect your ability to concentrate and react.
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Kidney
Natfost 500mg Injection is probably safe to use in patients
with kidney disease. Limited data available suggests that dose adjustment of Natfost 500mg Injection may not be needed in these patients. Please consult your doctor.
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Liver
There is limited information available on the use of Natfost
500mg Injection in patients with liver disease. Please consult your doctor.
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Patient Concerns

Frequently asked questions for Natfost 500mg Injection

Frequently asked questions for Amifostine

Yes, it is FDA an approved drug
Natfost is used to reduce toxicity to kidneys associated with cisplatin therapy in patients with advanced ovarian cancer, and in prevention of dry mouth (xerostomia) during radiotherapy for head and neck cancer
It protects the normal cells against the harmful effects of chemotherapy medications and radiation treatment by producing a chemical ‘thiol' that binds to and detoxifies the harmful compounds produced by cisplatin. Natfost does not interfere with the action of cisplatin.

Substitutes for Natfost Injection

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