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Naprosyn ES Tablet DR

Written By Dr. Swati Mishra, BDS
Reviewed By Dr. Rajeev Sharma, MBA, MBBS
Last updated on 10 Mar 2026 | 11:05 AM (IST)
Naprosyn ES Tablet DR is a combination medicine which helps in relieving pain. It is used to relieve pain and inflammation in conditions like rheumatoid arthritis, ankylosing spondylitis, and osteoarthritis. It is also used to relieve muscle pain, back pain, toothache, or pain in the ear and throat.
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General Information

Contains

Naproxen (500mg)+ Esomeprazole (20mg)

Marketer

RPG Life Sciences Ltd

Storage

Store below 25°C
The content is shown in English
Naprosyn ES Tablet DR image
Naprosyn ES Tablet DR image

Product introduction

Naprosyn ES Tablet DR should be taken with food. This will prevent you from getting an upset stomach. The dose will depend on what you are taking it for and how well it helps your symptoms. You should take it as advised by your doctor. Do not take more or use it for longer duration than recommended by the doctor.

The most common side effects of this medicine include headache, nausea, vomiting, diarrhea, indigestion, flatulence, and stomach pain. If any of these side effects bother you or get worse, you should speak to your doctor. Your doctor may be able to suggest ways of preventing or reducing the side effects.

Before taking it, you should let your doctor know if you have a history of ulcer or bleeding in your stomach, high blood pressure, or have any trouble with your heart, kidneys, or liver. Let your doctor also know about all the other medicines you are taking because they may affect, or be affected by, this medicine.

Pregnant or breastfeeding women should consult their doctor before starting treatment. You should also avoid drinking alcohol while you are taking this medicine, as alcohol can cause excessive drowsiness.

Uses of Naprosyn ES Tablet DR

Benefits of Naprosyn ES Tablet DR

Pain relief
Naprosyn ES Tablet DR relieves pain, reduce swelling and ease inflammation in conditions like rheumatoid arthritis and osteoarthritis. It also gives relief from muscle and back pain, toothache, or pain in the ear and throat. It works by reducing substances in the body that cause pain and swelling. Naprosyn ES Tablet DR contains an antacid which prevents acidity that might have occur due to this medicine.

Side effects of Naprosyn ES Tablet DR

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Naprosyn ES
  • Headache
  • Nausea
  • Vomiting
  • Diarrhea
  • Indigestion
  • Flatulence
  • Stomach pain
  • Flu-like symptoms

How to use Naprosyn ES Tablet DR

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Naprosyn ES Tablet DR should be taken with or after food.

How Naprosyn ES Tablet DR works

Naprosyn ES Tablet DR is a combination of two medicines: Naproxen and Esomeprazole which relieve pain. Naproxen is a non-steroidal anti-inflammatory drug (NSAID) which works by blocking the release of certain chemical messengers that cause fever, pain and inflammation (redness and swelling). Esomeprazole is a proton-pump inhibitor.which reduces the amount of acid in the stomach and prevents damage to the stomach lining caused by Naproxen.

Quick tips

  • Naprosyn ES Tablet DR is used to treat various painful conditions.
  • Take it with a glass of milk in order to prevent side effects such as indigestion.
  • If you have asthma, symptoms such as wheeze or breathlessness might get worse Naprosyn ES Tablet DR. In such a case see your doctor right away.
  • Inform your doctor if you have or ever had ulcers in your stomach or intestines.
  • Inform your doctor if you are planning to have an operation (even a minor one, such as tooth extraction) since Naprosyn ES Tablet DR increases the risk of bleeding.

Safety advice

Alcohol

Alcohol

CONSULT YOUR DOCTOR
It is not known whether it is safe to consume alcohol with Naprosyn ES Tablet DR. Please consult your doctor.
Pregnancy

Pregnancy

UNSAFE
Naprosyn ES Tablet DR is highly unsafe during pregnancy. It can cause serious harm to the unborn baby, including birth defects and pregnancy loss. Do not use this medicine if you are pregnant or planning to become pregnant.
Breast feeding

Breast feeding

UNSAFE
Naprosyn ES Tablet DR is unsafe to use during breastfeeding. Data suggests that the drug may cause toxicity to the baby.
Driving

Driving

CONSULT YOUR DOCTOR
It is not known whether Naprosyn ES Tablet DR alters the ability to drive. Do not drive if you experience any symptoms that affect your ability to concentrate and react. Please consult your doctor.
Naprosyn ES Tablet DR may make you feel dizzy, depressed, sleepy, tired, or make it difficult to sleep. It may also affect your vision. This may affect your driving ability.
Kidney

Kidney

CAUTION
Naprosyn ES Tablet DR should be used with caution in patients with kidney disease. Dose adjustment may be needed.
Liver

Liver

CAUTION
Naprosyn ES Tablet DR should be used with caution in patients with severe liver disease. Dose adjustment may be needed.

Frequently asked questions

Naprosyn ES Tablet DR is used to relieve pain and inflammation in conditions like arthritis. Naproxen in Naprosyn ES Tablet DR helps relieve pain, and esomeprazole in Naprosyn ES Tablet DR helps protect the stomach lining from ulcers that naproxen alone might cause.
Individuals should not take Naprosyn ES Tablet DR if they are allergic to naproxen, esomeprazole, aspirin, or other NSAIDs, or if they have had asthma, hives, or serious allergic reactions after using pain relievers. It should not be used by people with a history of stomach bleeding caused by NSAIDs.
Yes, naproxen in Naprosyn ES Tablet DR may increase the risk of serious heart conditions such as heart attack or stroke, especially with long-term use or in people with existing heart disease.
Before using Naprosyn ES Tablet DR, tell your doctor if you have high blood pressure, high cholesterol, diabetes, heart disease, kidney disease, liver disease, or if you smoke. These conditions may increase your risk of serious side effects.
Yes, naproxen in Naprosyn ES Tablet DR can cause stomach ulcers and bleeding. The esomeprazole in Naprosyn ES Tablet DR helps reduce this risk, but it does not completely prevent it. Watch for warning signs like black stools, vomiting blood, or severe stomach pain.
Serious side effects of Naprosyn ES Tablet DR include heart attack, stroke, kidney failure, liver injury, severe allergic reactions, and bleeding in the stomach or intestines. Get immediate medical help if you notice chest pain, shortness of breath, sudden weakness, or yellowing of the skin.
Stop taking Naprosyn ES Tablet DR and call your doctor if you develop chest pain, sudden weakness, shortness of breath, black stools, vomiting blood, unexplained weight gain, swelling of the body, or severe skin reactions.
Long-term use of Naprosyn ES Tablet DR can increase the risk of serious heart, kidney, and stomach problems. Doctors usually prescribe the lowest effective dose for the shortest time needed to reduce risks.

Fact Box

Habit Forming

No

Therapeutic Class

PAIN ANALGESICS

References

  1. Naproxen. Nutley, New Jersey: Roche Laboratories Inc. [Accessed 02 Apr. 2019] (online) Available from:
  2. ScienceDirect. Naproxen. [Accessed 23 Apr. 2019] (online) Available from:
  3. Esomeprazole. Wilmington, Delaware: AstraZeneca Pharmaceuticals; 1989 [revised Dec. 2014]. [Accessed 28 Mar. 2019] (online) Available from:
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User feedback

Twice A Day
53%
Once A Day
43%
Alternate Day
3%
Pain relief
100%
Average
78%
Excellent
22%
No Side Effect
67%
Vomiting
33%
With food
100%
Average
44%
Expensive
33%
Not Expensive
22%
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Disclaimer

Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: RPG Life Sciences Ltd
Address: 463, 4 th Floor, RPG HOUSE, Dr. Annie Besant Road, Worli, Mumbai – 400 030. Maharashtra, INDIA

Vendor Details

Country of origin: India

Lab tests offered by us

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Most medicines cannot be sold without a valid prescription, as per the Drugs and Cosmetics Act, 1940 and Rules, 1945
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