Naproflex 375mg/20mg Tablet

Reviewed By Dr. Rajeev Sharma, MBA, MBBS

Last updated on 22 Sep 2025 | 01:52 PM (IST)

Naproflex 375mg/20mg Tablet is a combination medicine which helps in relieving pain. It is used to relieve pain and inflammation in conditions like rheumatoid arthritis, ankylosing spondylitis, and osteoarthritis. It is also used to relieve muscle pain, back pain, toothache, or pain in the ear and throat.

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General Information

Contains

Naproxen (375mg)+ Esomeprazole (20mg)

Marketer

Zap Healthcare Pvt Ltd

Storage

Store below 30°C

The content is shown in English

Product introduction

Naproflex 375mg/20mg Tablet should be taken with food. This will prevent you from getting an upset stomach. The dose will depend on what you are taking it for and how well it helps your symptoms. You should take it as advised by your doctor. Do not take more or use it for longer duration than recommended by the doctor.

The most common side effects of this medicine include headache, nausea, vomiting, diarrhea, indigestion, flatulence, and stomach pain. If any of these side effects bother you or get worse, you should speak to your doctor. Your doctor may be able to suggest ways of preventing or reducing the side effects.

Before taking it, you should let your doctor know if you have a history of ulcer or bleeding in your stomach, high blood pressure, or have any trouble with your heart, kidneys, or liver. Let your doctor also know about all the other medicines you are taking because they may affect, or be affected by, this medicine.

Pregnant or breastfeeding women should consult their doctor before starting treatment. You should also avoid drinking alcohol while you are taking this medicine, as alcohol can cause excessive drowsiness.

Uses of Naproflex Tablet

Pain relief

Benefits of Naproflex Tablet

Pain relief
Naproflex 375mg/20mg Tablet relieves pain, reduce swelling and ease inflammation in conditions like rheumatoid arthritis and osteoarthritis. It also gives relief from muscle and back pain, toothache, or pain in the ear and throat. It works by reducing substances in the body that cause pain and swelling. Naproflex 375mg/20mg Tablet contains an antacid which prevents acidity that might have occur due to this medicine.

Side effects of Naproflex Tablet

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Naproflex

Headache
Nausea
Vomiting
Diarrhea
Indigestion
Flatulence
Stomach pain
Flu-like symptoms

How to use Naproflex Tablet

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Naproflex 375mg/20mg Tablet is to be taken with food.

How Naproflex Tablet works

Naproflex 375mg/20mg Tablet is a combination of two medicines: Naproxen and Esomeprazole which relieve pain. Naproxen is a non-steroidal anti-inflammatory drug (NSAID) which works by blocking the release of certain chemical messengers that cause fever, pain and inflammation (redness and swelling). Esomeprazole is a proton-pump inhibitor.which reduces the amount of acid in the stomach and prevents damage to the stomach lining caused by Naproxen.

Quick tips

Naproflex 375mg/20mg Tablet is used to treat various painful conditions.
Take it with a glass of milk in order to prevent side effects such as indigestion.
If you have asthma, symptoms such as wheeze or breathlessness might get worse Naproflex 375mg/20mg Tablet. In such a case see your doctor right away.
Inform your doctor if you have or ever had ulcers in your stomach or intestines.
Inform your doctor if you are planning to have an operation (even a minor one, such as tooth extraction) since Naproflex 375mg/20mg Tablet increases the risk of bleeding.

Safety advice

Alcohol

UNSAFE

It is unsafe to consume alcohol with Naproflex 375mg/20mg Tablet.

Pregnancy

CONSULT YOUR DOCTOR

Naproflex 375mg/20mg Tablet may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.

Breast feeding

SAFE IF PRESCRIBED

Naproflex 375mg/20mg Tablet is safe to use during breastfeeding. Human studies suggest that the drug does not pass into the breastmilk in a significant amount and is not harmful to the baby.

Driving

UNSAFE

Naproflex 375mg/20mg Tablet may cause side effects which could affect your ability to drive.
Naproflex 375mg/20mg Tablet may make you feel dizzy, depressed, sleepy, tired, or make it difficult to sleep. It may also affect your vision. This may affect your driving ability.

Kidney

CAUTION

Naproflex 375mg/20mg Tablet should be used with caution in patients with kidney disease. Dose adjustment of Naproflex 375mg/20mg Tablet may be needed. Please consult your doctor.

Liver

CAUTION

Naproflex 375mg/20mg Tablet should be used with caution in patients with liver disease. Dose adjustment of Naproflex 375mg/20mg Tablet may be needed. Please consult your doctor.

Frequently asked questions

What is Naproflex 375mg/20mg Tablet used for?

Naproflex 375mg/20mg Tablet is used to relieve pain and inflammation in conditions like arthritis. Naproxen in Naproflex 375mg/20mg Tablet helps relieve pain, and esomeprazole in Naproflex 375mg/20mg Tablet helps protect the stomach lining from ulcers that naproxen alone might cause.

Who should not take Naproflex 375mg/20mg Tablet?

Individuals should not take Naproflex 375mg/20mg Tablet if they are allergic to naproxen, esomeprazole, aspirin, or other NSAIDs, or if they have had asthma, hives, or serious allergic reactions after using pain relievers. It should not be used by people with a history of stomach bleeding caused by NSAIDs.

Can Naproflex 375mg/20mg Tablet increase the risk of heart problems?

Yes, naproxen in Naproflex 375mg/20mg Tablet may increase the risk of serious heart conditions such as heart attack or stroke, especially with long-term use or in people with existing heart disease.

What precautions should I take before using Naproflex 375mg/20mg Tablet?

Before using Naproflex 375mg/20mg Tablet, tell your doctor if you have high blood pressure, high cholesterol, diabetes, heart disease, kidney disease, liver disease, or if you smoke. These conditions may increase your risk of serious side effects.

Can Naproflex 375mg/20mg Tablet cause stomach bleeding?

Yes, naproxen in Naproflex 375mg/20mg Tablet can cause stomach ulcers and bleeding. The esomeprazole in Naproflex 375mg/20mg Tablet helps reduce this risk, but it does not completely prevent it. Watch for warning signs like black stools, vomiting blood, or severe stomach pain.

Are there any serious side effects of Naproflex 375mg/20mg Tablet?

Serious side effects of Naproflex 375mg/20mg Tablet include heart attack, stroke, kidney failure, liver injury, severe allergic reactions, and bleeding in the stomach or intestines. Get immediate medical help if you notice chest pain, shortness of breath, sudden weakness, or yellowing of the skin.

What signs should I watch for that mean I should stop Naproflex 375mg/20mg Tablet immediately?

Stop taking Naproflex 375mg/20mg Tablet and call your doctor if you develop chest pain, sudden weakness, shortness of breath, black stools, vomiting blood, unexplained weight gain, swelling of the body, or severe skin reactions.

Is long-term use of Naproflex 375mg/20mg Tablet safe?

Long-term use of Naproflex 375mg/20mg Tablet can increase the risk of serious heart, kidney, and stomach problems. Doctors usually prescribe the lowest effective dose for the shortest time needed to reduce risks.

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Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: Zap Healthcare Pvt Ltd
Address: FF-26, Block C, Omaxe Mall, Sector 48, Sohna Road, Gurgaon 122003.

Vendor Details

Country of origin: India

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