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Migrasaf Tablet is a prescription medicine used in the treatment of migraine. It prevents pain signals and fever associated with migraine. It also blocks certain substances in the brain that trigger nausea or vomiting during migraine headaches.

Written By Dr. Lipika Khurana, PGDHHM, BDS,
Reviewed By Dr. Mekhala Chandra, MD, MBBS,
Last updated on 25 Nov 2025 | 03:07 PM (IST)
₹85.5 MRP ₹93.759% off 
As per Ministry of Health and Family Welfare
Gurgaon
 
 
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General Information

Contains

Domperidone (10mg)+ Flunarizine (5mg)+ Paracetamol (325mg)

Marketer

SAF Fermion Ltd

Storage

Store below 30°C
The content is shown in English
Migrasaf Tablet image
Migrasaf Tablet image

Product introduction

Migrasaf Tablet is taken without food in a dose and duration as advised by the doctor. The dose you are given will depend on your condition and how you respond to the medicine. You should keep taking this medicine for as long as your doctor recommends. If you stop treatment too early your symptoms may come back and your condition may worsen. Let your healthcare team know about all other medications you are taking as some may affect, or be affected by this medicine.

The most common side effects are weight gain, and dryness in the mouth. These are temporary and usually resolve with time. Contact your doctor straight away if you are at all concerned about any of these side effects. It may also cause drowsiness, so do not drive or do anything that requires mental focus until you know how this medicine affects you. Avoid drinking alcohol while taking this medicine as it can worsen your drowsiness.

Migraine attacks can be managed by identifying migraine-causing triggers which may be red wine, caffeine withdrawal, stress, and skipped meals, etc. You can identify personal triggers by maintaining a diary of what you are doing, what you are eating, and any stressful activity happened before migraine attack. Before taking this medicine, you should tell your doctor if you are pregnant, planning pregnancy or breastfeeding. You should also tell your doctor if you have any liver diseases.

Uses of Migrasaf Tablet

Benefits of Migrasaf Tablet

Migraine
Migrasaf Tablet is a combination of medicines that treat and prevent migraine headaches. It changes the electrical activity in the brain, blocks chemicals responsible for pain sensation and also blocks signals that cause nausea/vomiting associated with migraines. By preventing and reducing the frequency of migraine headaches, it can help you carry out your daily activities and have a better quality of life.

Side effects of Migrasaf Tablet

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Migrasaf
  • Weight gain
  • Drowsiness
  • Dryness in mouth

How to use Migrasaf Tablet

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Migrasaf Tablet is to be taken on an empty stomach.

How Migrasaf Tablet works

Migrasaf Tablet is a combination of three medicines: Domperidone, Flunarizine and Paracetamol which prevent migraine accompanied by nausea/vomiting. Domperidone is an antiemetic and prokinetic which blocks the action of a dopamine (a chemical messenger) in the brain which causes nausea and vomiting. Flunarizine is a calcium channel blocker which works by preventing the narrowing of blood vessels in the head thereby preventing migraine headache. Paracetamol is an analgesic (pain reliever) and antipyretic (fever reducer). It blocks the release of certain chemical messengers in the brain that are responsible for pain.

Quick tips

  • Migrasaf Tablet helps to ease the pain you feel during a migraine headache as well as helps to stop you from feeling sick.
  • It can make you feel dizzy, rise slowly if you have been sitting or lying down for a long time.
  • Dry mouth may occur as a side effect. Frequent mouth rinses, good oral hygiene, increased water intake and sugarless candy may help.
  • Migrasaf Tablet can only decrease the number and severity of attacks but may not completely stop them.
  • Some tips that may help avoid a migraine attack:
    1. Have your meals at the same time every day.
    2. Avoid bright lights and extreme temperatures.
    3. Avoid loud music and noisy places.
    4. Avoid chocolates,  cheese, processed food, alcohol, and smoking.
    5. f) Get sufficient sleep and avoid stress.

Safety advice

Alcohol

Alcohol

UNSAFE
It is unsafe to consume alcohol with Migrasaf Tablet
Pregnancy

Pregnancy

CONSULT YOUR DOCTOR
The safety of Migrasaf Tablet during pregnancy has not been established. There are no adequate and well-controlled studies in pregnant women, and animal data on reproductive toxicity are insufficient. Your doctor will weigh the benefits and any potential risks before prescribing.
Breast feeding

Breast feeding

CONSULT YOUR DOCTOR
Information regarding the use of Migrasaf Tablet during breastfeeding is not available. Please consult your doctor.
Driving

Driving

UNSAFE
Migrasaf Tablet may decrease alertness, affect your vision, or make you feel sleepy and dizzy. Do not drive if these symptoms occur.
Kidney

Kidney

SAFE IF PRESCRIBED
Migrasaf Tablet is probably safe to use in patients with kidney disease. Limited data suggest dose adjustment may not be needed.
Liver

Liver

CAUTION
Migrasaf Tablet should be used with caution in patients with liver disease. Dose adjustment may be needed.
However, the use of Migrasaf Tablet is not recommended in patients with severe liver disease and active liver disease.

Frequently asked questions

Migrasaf Tablet is used in the treatment of migraine attack. This medicine should be continued as advised by the doctor.
No, you should not drink alcohol using Migrasaf Tablet. Drinking alcohol while taking Migrasaf Tablet can make you feel very drowsy and sleepy.
Yes, the use of Migrasaf Tablet can cause dry mouth. If you experience dry mouth, drink plenty of water. Take regular sips during the day and keep some water by your bed at night. You may use lip balm if your lips are also dry. Try to avoid foods that are acidic (like lemons), spicy and salty.
Certain physical or environmental factors, such as foods, hormonal changes, weather, and stress, can lead to or “trigger” a migraine. However, it’s important to remember that triggers are different for everyone. That’s why, to help prevent migraine attacks, you need to figure out which triggers affect you and which ones don’t. Keeping a headache diary is an effective way to track triggers, and it will help you talk to your healthcare professional about your condition.
No, taking higher than recommended dose of Migrasaf Tablet can lead to increased side effects. If you are experiencing increased severity of migraine attacks, which are not relieved by the recommended doses, please consult your doctor for re-evaluation.
Keep this medicine in the packet or container it came in, tightly closed. Store it as mentioned on the pack or label. Dispose of the unused medicine. Make sure it is not consumed by pets, children, and other people.
Migrasaf Tablet can cause sleepiness, dizziness or drowsiness. If you have these symptoms, do not drive a car, use machinery, or do anything where you need to be alert.

Fact Box

Habit Forming

No

Therapeutic Class

NEURO CNS

References

  1. Domperidone maleate. South Ruislip, Middlesex: Aurobindo Pharma - Milpharm Ltd.; 2017. [Accessed 15 Feb. 2019] (online) Available from:
  2. ScienceDirect. Flunarizine. [Accessed 12 Apr. 2019] (online) Available from:
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User feedback

Once A Day
56%
Twice A Day
33%
Thrice A Day
11%
Migraine
75%
Headache
25%
Average
47%
Poor
33%
Excellent
20%
No Side Effect
43%
Dryness in mouth
29%
Weight gain
14%
Drowsiness
14%
With food
75%
With or without food
25%
Average
58%
Expensive
25%
Not Expensive
17%
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Disclaimer

Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: SAF Fermion Ltd
Address: Millennium City Information Technology Park, Tower-II, Plot No. 62, Block-DN, Sector V, 8th floor, Salt Lake, Kolkata: 700 091

Vendor Details

Country of origin: India

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