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MRP: Rs. 153.85 for 1 vial(s) (1 injection each)
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Composition for MEGAZONE S

Cefoperazone(500 mg),Sulbactam(500 mg)

food interaction for MEGAZONE S

alcohol interaction for MEGAZONE S

pregnancy interaction for MEGAZONE S

lactation interaction for MEGAZONE S

There is no data available. Please consult doctor before consuming the drug.
Megazone s 500mg/500mg injection may cause symptoms such as flushing, increased heartbeat, nausea, thirst, chest pain and low blood pressure with alcohol (Disulfiram reactions).
Megazone s 500mg/500mg injection is probably safe to use during pregnancy.
Either animal studies have shown no adverse effect on the fetus, but there is no human studies or animal studies have shown an adverse effect that was not confirmed in human studies. Please consult your doctor.
Unknown. Human and animal studies are not available. Please consult your doctor.


Cefoperazone(500 mg)


Cefoperazone is used to treat bacterial infection of the respiratory tract, the abdomen and abdominal wall (peritonitis), the urinary tract, the female genital tract (endometritis, pelvic inflammatory disease), the blood (septicemia), and the skin and soft tissues. 

How it works

Cefoperazone belongs to group of medicines called third-generation cephalosporin antibiotics. It kills the bacteria by interrupting the bacterial cell wall (outer coating of bacteria) formation. As a result, the bacterial cell wall is weakened and ruptures, thereby killing the bacteria. 

Common side effects

Nausea, Increased creatine level in blood, Increased urea nitrogen level in blood, Liver enzyme increased, Allergic reaction, Decreased haemoglobin level in blood, Diarrhoea, Inflammation of vein, Drug fever, Decreased white blood cell count, Decreased white blood cell count (eosinophils), Vomiting
Sulbactam(500 mg)


Sulbactam is used in combination with other antibiotics for treating certain bacterial infections. It is used to treat intraabdominal, gynecological, skin or soft tissue, and surgal infections, especially those developed in the hospital.

How it works

Sulbactam belongs to group of medicines called betalactamase Inhibitor with very weak action against bacteria.  Beta-lactamase inhibitors are available only in fixed combinations with specific penicillins (beta-lactam antibiotics) such as amoxicillin, ampicillin, piperacillin, and ticarcillin. It works by preventing destruction of beta-lactam antibiotics from chemicals released from bacteria and extends their spectrum of activity.

Common side effects

Vomiting, Nausea, Diarrhoea, Abdominal pain, Jaundice, Abnormal liver function tests, Allergic reaction, Hives, Redness of skin, Ankle swelling, Limb swelling, Difficulty in swalloing, Shortness of breath, Facial swelling, Skin swelling, Tongue swelling, Throat swelling, Injection site bruising, Injection site bleeding, Stomach cramp, Wheezing


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Expert advice for MEGAZONE S

Cefoperazone is usually given by a doctor or a nurse as an injection directly into the vein or muscle. Tell your doctor if you are taking cefoperazone and undergoing any blood or urine test, as it may affect the result. Do not start or continue the cefoperazone and consult your doctor:
  • If you have history of allergy due to cefoperazone or any other cephalosporin or penicillin antibiotics.
  • If you experience severe and persistent diarrhea after taking antibiotics.
  • If you are already taking any other antibiotic like aminoglycosides or other cephalosporins as it may cause kidney toxicity.

Frequently asked questions for MEGAZONE S


Q. What is cefoperazone sulbactam?
Combination of cefoperazone and sulbactam (beta lactamase inhibitor) are used for the treatment of intra-abdominal infections.
Q. Is cefoperazone nephrotoxic?
No, cefoperazona is not a nephrotoxic drug when given alone, but when given along with aminoglycosides (gentamicin, tobramycin) or other cephalosporins antibiotics, it may increase nephrotoxicity. Please consult your doctor before taking the drug.
Q. Is cefoperazone safe?
Cefoperazone is safe if used at prescribed doses for the prescribed duration as advised by your doctor.


Q. Is sulbactam a sulfa (sulfonamide) drug?
Sulbactam does not contain sulfa. It is a semisynthetic beta lactamase Inhibitor.
Q. What is sulbactam sodium?
Sulbactam is a beta-lactamase inhibitor used as the sodium salt to increase the antibacterial activity of penicillins.
Q. Is sulbactam safe?
Sulbactam is relatively safe if used at prescribed doses for the prescribed duration as advised by your doctor.


Content on this page was last updated on 19 December, 2014, by Dr. Varun Gupta (MD Pharmacology)