Mebrest Plus Tablet

Mebeverine (135mg)+ Chlordiazepoxide (5mg)

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Mebrest Plus Tablet is used to treat irritable bowel syndrome (symptoms include abdominal pain, cramping, bloating, and diarrhea or constipation). It prevents the sudden spasm of muscles to relieve stomach pain and cramps. It also promotes easy passage of gas to reduce stomach discomfort.

Written By Dr. Syeda Aafia, MBA, BDS,
Reviewed By Dr. Rajeev Sharma, MBA, MBBS,
Last updated on 31 Mar 2026 | 02:32 PM (IST)

₹135 MRP ₹149.069% off

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General Information

Contains

Mebeverine (135mg)+ Chlordiazepoxide (5mg)

Marketer

Matteo Healthcare Pvt Ltd

Storage

Store below 30°C

The content is shown in English

Product introduction

Mebrest Plus Tablet is taken without food in a dose and duration as advised by the doctor. The dose you are given will depend on your condition and how you respond to the medicine. You should keep taking this medicine for as long as your doctor recommends. If you stop treatment too early your symptoms may come back and your condition may worsen. Let your healthcare team know about all other medications you are taking as some may affect, or be affected by this medicine.

There is limited data on the side effects of Mebrest Plus Tablet. Let your doctor know if you experience any symptoms while taking the medicine. They can suggest ways to treat or manage the side effects.

Before you start Mebrest Plus Tablet, let your doctor know if you have any medical conditions. Let your doctor also know about all the medications you are taking, as some medicines may interact with Mebrest Plus Tablet. Pregnant or breastfeeding women should consult their doctor before taking Mebrest Plus Tablet to ensure safety.

Uses of Mebrest Plus Tablet

Irritable bowel syndrome

Benefits of Mebrest Plus Tablet

Irritable bowel syndrome
Irritable Bowel Syndrome (IBS) is a chronic condition that causes abdominal pain, bloating, gas, and irregular bowel movements. Mebrest Plus Tablet offers dual relief: It relaxes the intestinal muscles to ease cramps, discomfort, and helps reduce anxiety, which often worsens IBS symptoms. This medicine improves digestive comfort and helps restore regular bowel habits, making daily life more manageable.

Side effects of Mebrest Plus Tablet

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Mebrest Plus

Limited data available

How to use Mebrest Plus Tablet

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Mebrest Plus Tablet may be taken with or without food.

How Mebrest Plus Tablet works

Mebrest Plus Tablet is a combination of two medicines: Mebeverine and Chlordiazepoxide.

Quick tips

You have been prescribed Mebrest Plus Tablet for the treatment of pain and other discomfort associated with irritable bowel syndrome.
Do not take Mebrest Plus Tablet at least 2 hours before or after taking other medicines as it may interact with other medicines.
Inform your doctor if you have an enlarged prostate gland, glaucoma, or trouble passing urine.
To lower the chance of feeling dizzy or passing out, rise slowly if you have been sitting or lying down.

Safety advice

Alcohol

CONSULT YOUR DOCTOR

It is not known whether it is safe to consume alcohol with Mebrest Plus Tablet. Please consult your doctor.

Pregnancy

CONSULT YOUR DOCTOR

Information regarding the use of Mebrest Plus Tablet during pregnancy is not available. Please consult your doctor.

Breast feeding

CONSULT YOUR DOCTOR

Mebrest Plus Tablet may be unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby. It should be used only if the expected benefit outweighs the potential risk. Please consult your doctor.

Driving

CONSULT YOUR DOCTOR

It is not known whether Mebrest Plus Tablet alters the ability to drive. Do not drive if you experience any symptoms that affect your ability to concentrate and react. Please consult your doctor.
As Mebrest Plus Tablet may make you feel drowsy or affect your concentration and this may affect your ability to drive.

Kidney

CONSULT YOUR DOCTOR

There is limited data available on the use of Mebrest Plus Tablet in patients with kidney disease. Please consult your doctor.
Caution is advised in patients with severe kidney disease.

Liver

CONSULT YOUR DOCTOR

There is limited data available on the use of Mebrest Plus Tablet in patients with liver disease.
Caution is advised in patients with severe liver disease.

Frequently asked questions

Can Mebrest Plus Tablet cause withdrawal symptoms?

Yes, Mebrest Plus Tablet may cause withdrawal symptoms. Do not stop taking Mebrest Plus Tablet all of a sudden. Stopping Mebrest Plus Tablet suddenly can cause seizures, shaking, stomach and muscle cramps, vomiting and sweating. Consult with your doctor before stopping Mebrest Plus Tablet.

Can I drink alcohol while taking Mebrest Plus Tablet?

No, avoid drinking alcohol while you are taking Mebrest Plus Tablet. Drinking alcohol can increase the risk of side effects like drowsiness or sleepiness.

Can the use of Mebrest Plus Tablet cause sleepiness or drowsiness?

Yes, Mebrest Plus Tablet may make you feel drowsy or sleepy. Avoid driving, operating any machines, working at heights or participating in potentially dangerous activities at the start of your treatment. Inform your doctor if you experience such episodes while taking this medicine.

What precautions do I need to take while using Mebrest Plus Tablet?

Mebrest Plus Tablet should not be taken along with opioid-like substances as it contains chlordiazepoxide. Use of opioids along with chlordiazepoxide may cause excessive sedation (state of calm or sleep), respiratory depression and eventually coma or death. Inform your doctor about all the medicines that you are taking if you are advised to take Mebrest Plus Tablet.

What are the symptoms of overdose of Mebrest Plus Tablet?

Both Mebeverine and Chlordiazepoxide show different symptoms of overdose. Chlordiazepoxide can cause sleepiness, reflexes, confusion and coma. Whereas, Mebeverine can cause CNS excitability which is mild and reversible. Inform the doctor in case you take a higher dose and any of these symptoms appear.

Can the use of Mebrest Plus Tablet cause constipation?

Yes, the use of Mebrest Plus Tablet can cause constipation. Eat high-fiber foods like vegetables, fruits and cereals, and drink plenty of water. Exercise regularly by engaging in activities like swimming, jogging or taking a walk. Consult a doctor if the constipation persists for a long duration.

What are the instructions for storage and disposal of Mebrest Plus Tablet?

Keep this medicine in the container it came in, tightly closed. Store it according to the instructions mentioned on the pack or label. Dispose of the unused medicine. Make sure it is not consumed by pets, children and other people.

Fact Box

Habit Forming

Yes

Therapeutic Class

GASTRO INTESTINAL

Related lab tests

Complete Blood Count

References

Daniluk J, Malecka-Wojciesko E, Skrzydlo-Radomanska B, et al. The Efficacy of Mebeverine in the Treatment of Irritable Bowel Syndrome-A Systematic Review. J Clin Med. 2022;11(4):1044. [Accessed 22 Nov. 2025]. Available from:

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Disclaimer

Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: Matteo Healthcare Pvt Ltd
Address: 101-104 GCP Business centre opp. Memnagar fire station Vijay cross road Memnagar , Ahmedabad-380014 India.

Vendor Details

Country of origin: India

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Why we need a prescription?

Mebrest Plus Tablet

Save more with additional offers

General Information

Contains

Marketer

Storage

Product introduction

Uses of Mebrest Plus Tablet

Benefits of Mebrest Plus Tablet

Side effects of Mebrest Plus Tablet

How to use Mebrest Plus Tablet

How Mebrest Plus Tablet works

Quick tips

Safety advice

Alcohol

Pregnancy

Breast feeding

Driving

Kidney

Liver

Frequently asked questions

Can Mebrest Plus Tablet cause withdrawal symptoms?

Can I drink alcohol while taking Mebrest Plus Tablet?

Can the use of Mebrest Plus Tablet cause sleepiness or drowsiness?

What precautions do I need to take while using Mebrest Plus Tablet?

What are the symptoms of overdose of Mebrest Plus Tablet?

Can the use of Mebrest Plus Tablet cause constipation?

What are the instructions for storage and disposal of Mebrest Plus Tablet?

Fact Box

Habit Forming

Therapeutic Class

Related lab tests

Complete Blood Count

References

Want to know more

Have issue with the content

Disclaimer

Marketer details

Vendor Details

Lab tests offered by us

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