Overview
Uses and benefits
Side effects
How to use
How drug works
Safety advice
Missed dose
All substitutes
Quick tips
Fact box
Patient concerns
FAQs

Author Details

Written By

Dr. Mayank

Pharm.D

Reviewed By

Dr. Sachin Gupta

MD Pharmacology, MBBS

Last updated

21 Sep 2025 | 10:29 PM (IST)

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MDS-O 200mg Tablet

Prescription Required

Marketer

Adley Formulations

SALT COMPOSITION

Azacitidine (200mg)

Storage

Store below 30°C

View available alternative with same salt composition

Click here to view all substitutes

Product introduction

MDS-O 200mg Tablet is used in the treatment of some kinds of blood cancer. It is used for the treatment of adult patients with all subtypes of Myelodysplastic Syndrome (MDS). It may be also used to treat other conditions, as determined by the doctor.

MDS-O 200mg Tablet can be taken with or without food, but better to have it same time every day. Your doctor will decide what dose is necessary and how often you need to take it. This will depend on what you are being treated for and may change from time to time. You should take it exactly as your doctor has advised. Taking it in the wrong way or taking too much can cause very serious side effects. It may take several weeks or months for you to see or feel the benefits but do not stop taking it unless your doctor tells you to.

The most common side effects of this medicine include vomiting, weakness, nausea, and fever. If these bother you or appear serious, let your doctor know. There may be ways of reducing or preventing them. You must inform your doctor before taking any vaccination while on treatment with this medicine. Regular blood tests are required to check your blood cells along with the heart, liver, and kidney.

Before taking it, tell your doctor if you have liver, or kidney problems or are taking any medicines to treat infections. Many other medicines can affect, or be affected by, this medicine so let your doctor know all medications you are using. This medicine is not recommended during pregnancy or while breastfeeding.

Uses of MDS-O Tablet

Benefits of MDS-O Tablet

In Blood cancer

Blood cancer, also called leukemia, is a cancer of the blood-forming tissues, that decreases the body's ability to fight infection. MDS-O 200mg Tablet kills or stops the growth of cancer cells and also prevents the multiplication of cancer cells. It is a potent and very toxic medicine and you should discuss the risks and benefits with your doctor. You should avoid drinking alcohol while having this treatment and drink plenty of water to stay hydrated.

In Treatment of Myelodysplastic syndrome

MDS-O 200mg Tablet is used to treat myelodysplastic syndrome, a group of conditions in which the bone marrow produces blood cells that are abnormal in structure and function, and does not produce enough healthy blood cells. MDS-O 200mg Tablet kills or stops the growth of cancer cells and also prevents the multiplication of cancer cells. It is an effective, yet very toxic medicine and you should discuss the risks and benefits with your doctor. You should avoid drinking alcohol while having this treatment and drink plenty of water to stay hydrated.

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Side effects of MDS-O Tablet

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of MDS-O

Vomiting
Weakness
Nausea
Decreased potassium level in blood
Bruise
Fever
Chills
Diarrhea
Constipation

How to use MDS-O Tablet

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. MDS-O 200mg Tablet may be taken with or without food, but it is better to take it at a fixed time.

How MDS-O Tablet works

MDS-O 200mg Tablet is an anticancer medication. It works by interfering with the growth of genetic material (DNA and RNA) of the cancer cells in leukaemia. This kills the cancer cells and helps in normal maturation and growth of young blood cells in the bone marrow.

Safety advice

Alcohol

CONSULT YOUR DOCTOR

It is not known whether it is safe to consume alcohol with MDS-O 200mg Tablet. Please consult your doctor.

Pregnancy

CONSULT YOUR DOCTOR

MDS-O 200mg Tablet is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. However, the doctor may rarely prescribe it in some life-threatening situations if the benefits are more than the potential risks. Please consult your doctor.

Breast feeding

UNSAFE

MDS-O 200mg Tablet is unsafe to use during breastfeeding. Data suggests that the drug may cause toxicity to the baby.

Driving

UNSAFE

MDS-O 200mg Tablet may cause side effects which could affect your ability to drive.
MDS-O 200mg Tablet can cause side effects such as tiredness and this may affect your ability to drive.

Kidney

CAUTION

MDS-O 200mg Tablet should be used with caution in patients with kidney disease. Dose adjustment of MDS-O 200mg Tablet may be needed. Please consult your doctor.

Liver

CAUTION

MDS-O 200mg Tablet should be used with caution in patients with liver disease. Dose adjustment of MDS-O 200mg Tablet may be needed. Please consult your doctor.
Use of MDS-O 200mg Tablet is not recommended in patients with advanced liver cancer.

What if you forget to take MDS-O Tablet?

If you miss a dose of MDS-O 200mg Tablet, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.

All substitutes

For informational purposes only. Consult a doctor before taking any medicines.

MDS-O 200mg Tablet

₹476.93/Tablet

Xpreza 200mg Tablet

Natco Pharma Ltd

₹750/tablet

57% costlier

Azacytin 200mg Tablet

Dr Reddy's Laboratories Ltd

₹835.07/tablet

75% costlier

BD-Zadine 200 Tablet

BDR Pharmaceuticals Internationals Pvt

₹1075.79/tablet

126% costlier

Quick tips

Use a reliable contraceptive method to prevent pregnancy while you are taking this medicine.
Inform your doctor immediately if you notice any signs of infection such as fever, sore throat, rash or severe diarrhea.

Fact Box

Chemical Class

Pyrimidine Nucleoside Analogue

Habit Forming

Therapeutic Class

ANTI NEOPLASTICS

Action Class

Antimetabolites

Patient concerns

My PATIENT having cancer in urinary bladder, now it is removed and histopathology lab report says the disease is not there any more in body no kemo is required. But the further medicine given for 3 month are very costly which are only for vitamin. Need the genuine ans and generic medicine. As there is no condition to take so much expensive medicine. Bcoz operation has done with the help of charity and trust.

Dr. Vijay Sharnangat

Medical Oncology and Hematology

Yes o please share details

My teeth is pain regulary since last 1 month

Dr. Rajesh Aduri

Paediatric and Preventive Dentistry

Meet a good dentist preferably MDS near you and get an X ray done

The patient is my mother who was suffering from pancytopenia for more than a year. She got her bone marrow test and biopsy done last month the MDS FISH panel and cytogenetics reports were negative but the gave a provisional diagnosis of MDS. .her platelets are 58000. .Please advise if it is MDS or something else as the says we need to just monitor her CBC and wait till the platelets drop to 20000 then some injections can be given. I am attaching all her reports please advise what should we do

Dr. Vijay Sharnangat

Medical Oncology and Hematology

I would suggest to go for repeat bone marrow aspiration previous sample contain only peripheral blood, do it at good centre and preferably by DM MEDICAL ONCOLOGIST.

Is MDS-O 200mg Tablet a vesicant?

MDS-O 200mg Tablet is not a vesicant and is not known to cause severe local tissue damage upon extravasation (leaking of injected MDS-O 200mg Tablet into the surrounding tissues from the site of administration) when injected

Does MDS-O 200mg Tablet cause hair loss?

No, MDS-O 200mg Tablet is not known to cause hair los

Is MDS-O 200mg Tablet chemotherapy?

Yes. MDS-O 200mg Tablet is chemotherapy and a cytotoxic drug used in the treatment of various cancers. It is toxic to cancer cells and interferes with the cell's DNA synthesis, thus slowing down or stopping its growth and multiplication (cytotoxic effect)

Is MDS-O 200mg Tablet a cytotoxic drug?

Yes. MDS-O 200mg Tablet is a cytotoxic drug.

Related lab tests

Bone Marrow Smear Microscopy Examination

Complete Blood Count

Peripheral Smear Examination

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Disclaimer:

Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

References

Chabner BA, Bertino J, Cleary J, et al. Cytotoxic Agents. In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. 12th ed. New York, New York: McGraw-Hill Medical; 2011. p. 1700.
Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 112-13.