Macrogol Sachet

Potassium Chloride (46.6mg)+ Sodium Chloride (350.7mg)+ Sodium Bicarbonate (178.5mg)+ Polyethylene Glycol (13.125gm)

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Macrogol Sachet is a combination medicine used in the treatment of constipation and Intestine preparation before any surgery. The medicine works by drawing water into the intestines and softening the stool, which promotes bowel movements. It also helps in maintaining electrolyte balance.

Written By Dr. Subita Alagh, BDS,
Reviewed By Dr. Rajeev Sharma, MBA, MBBS,
Last updated on 30 Apr 2026 | 06:05 PM (IST)

₹36.6 MRP ₹44.5318% off

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General Information

Contains

Potassium Chloride (46.6mg)+ Sodium Chloride (350.7mg)+ Sodium Bicarbonate (178.5mg)+ Polyethylene Glycol (13.125gm)

Marketer

Ajanta Pharma Limited

Storage

Store below 30°C

The content is shown in English

Product introduction

Take Macrogol Sachet in the dose and duration as advised by the doctor. The dose you are given will depend on the severity of your condition and how you respond to the medicine. You should keep taking this medicine for as long as your doctor recommends. If you stop treatment too early your symptoms may come back and your condition may worsen.

The medicine is usually safe with little or no side effects. However, let your doctor know if you experience any symptoms on taking the medicine. Lifestyle modifications like having a fiber-rich diet, increasing fluid intake, and regular exercise can help you to get better results.

Before taking this medicine, let your doctor know about all other medications you are taking as some may affect, or be affected by this medicine. You should also tell your doctor if you have any liver diseases so that your doctor can prescribe a suitable dose for you. Macrogol Sachet is generally considered safe to be used during pregancy or breastfeeding.

Uses of Macrogol Oral Solution

Treatment of Constipation

Benefits of Macrogol Oral Solution

Treatment of Constipation
Macrogol Sachet provides relief from constipation by softening the stool, increasing its volume, and facilitating easier passage through the intestines. Use it in the exact dose and duration advised by the doctor for maximum benefits.

Side effects of Macrogol Oral Solution

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Macrogol

Nausea
Abdominal cramp
Bloating
Vomiting
Anal irritation

How to use Macrogol Oral Solution

Take this medicine in the dose and duration as advised by your doctor. Check the label for directions before use. Measure it with a measuring cup and take it by mouth. Shake well before use. Macrogol Sachet may be taken with or without food.

How Macrogol Oral Solution works

Macrogol Sachet contains potassium chloride, sodium chloride, sodium bicarbonate, and polyethylene glycol. Potassium chloride works by raising potassium levels in your blood. Sodium chloride is a purified salt solution which works by replenishing salt and electrolyte levels in the body. Sodium bicarbonate is an alkalizer. It works by increasing the pH of blood and urine, thereby correcting metabolic acidosis (high acid levels in the body). It also speeds up the removal of toxic substances from the body in certain types of poisoning. In case of excessive fluid loss (such as in diarrhea), it works by replenishing salt and electrolyte levels. Polyethylene glycol works by drawing water into the intestine through osmosis, which makes the stool soft and easier to pass. It also helps clean out the intestines prior to medical procedures or examination.

All substitutes for Macrogol Sachet

For information purposes only. Consult a doctor before taking any medicine.

Movicol Liquid One Dose Orange

by Win-Medicare Pvt Ltd

₹51.56/oral solution

16% costlier

Quick tips

Mix Macrogol Sachet freshly each time and use immediately. Do not store any leftover prepared medicine, as it may lose its effectiveness or become unsafe to consume.
Do not take Macrogol Sachet if you have kidney, heart problems, high blood pressure or high blood potassium level.
Macrogol Sachet is usually taken once a day as needed for up to 2 weeks. Take it exactly as prescribed by the doctor.
Take Macrogol Sachet at least 2 hours after taking other medicines, as it may interfere with the absorption of other medicines.
Inform your doctor if you have a history of stomach disorders such as appendicitis or a blockage in your bowel.

Safety advice

Alcohol

CONSULT YOUR DOCTOR

It is not known whether it is safe to consume alcohol with Macrogol Sachet. Please consult your doctor.

Pregnancy

CONSULT YOUR DOCTOR

The safety of Macrogol Sachet during pregnancy has not been established. There are no adequate and well-controlled studies in pregnant women, and animal data on reproductive toxicity are insufficient. Your doctor will weigh the benefits and any potential risks before prescribing.

Breast feeding

SAFE IF PRESCRIBED

Available human data suggest that the drug does not pass into breast milk in clinically significant amounts and is unlikely to harm the infant.

Driving

CONSULT YOUR DOCTOR

It is not known whether Macrogol Sachet alters the ability to drive. Do not drive if you experience any symptoms that affect your ability to concentrate and react. Please consult your doctor.

Kidney

CAUTION

Macrogol Sachet should be used with caution in patients with kidney disease. Dose adjustment may be needed.

Liver

CAUTION

Macrogol Sachet should be used with caution in patients with liver disease. Dose adjustment may be needed.

Frequently asked questions

What is Macrogol Sachet used for?

Macrogol Sachet is used as a bowel cleanser for colonoscopy procedures, certain bowel surgeries, and other bowel examinations. It helps empty the intestines by causing watery stools, making it easier for doctors to examine the colon.

How should I take Macrogol Sachet for colonoscopy preparation?

You must mix the Macrogol Sachet with lukewarm water to make 4 liters of clear solution. Drink 240 mL (about 1 glass) every 10 minutes until the full volume is consumed or your stool becomes watery and clear. The solution should never be taken as dry powder or mixed with flavored drinks unless advised by the doctor.

Can I take my regular medicines with this colon preparation Macrogol Sachet?

No. Do not take other oral medications within 1 hour of drinking the Macrogol Sachet, as they may not be absorbed properly. Inform your doctor about all medications, especially those that affect kidneys, heart rhythm, or fluid balance.

Who should not take Macrogol Sachet?

Individuals should not take Macrogol Sachet if they have intestinal blockage (ileus), bowel perforation, toxic colitis, severe kidney or heart problems, or known allergy to PEG or any of the ingredients present in Macrogol Sachet.

Can I eat or drink before taking Macrogol Sachet for colonoscopy?

Yes, you may have a light breakfast and clear liquids earlier in the day before you consume Macrogol Sachet. Avoid red or purple-colored drinks, dairy, or solid foods. After starting the prep, drink only clear fluids up to 2 hours before the colonoscopy.

How long does Macrogol Sachet take to start working?

You may have your first bowel movement within 1 hour after drinking Macrogol Sachet. Continue drinking the solution until your stool is clear and watery, which means your bowel is fully cleaned.

Can Macrogol Sachet cause dehydration or electrolyte imbalance?

Yes. Macrogol Sachet can cause loss of body fluids and essential salts, leading to dehydration, kidney problems, or irregular heartbeat. Drink plenty of clear fluids during the prep, and stop if you feel faint, dizzy, or very weak.

What should I do if I vomit after taking the Macrogol Sachet?

If you vomit and cannot keep drinking Macrogol Sachet, stop drinking temporarily. Try again after a short break. If vomiting continues, contact your doctor as you may need an alternative preparation method.

Fact Box

Habit Forming

Therapeutic Class

GASTRO INTESTINAL

References

Swartz ML. NuLYTELY (PEG 3350, sodium chloride, sodium bicarbonate and potassium chloride for oral solution). Gastroenterol Nurs. 1992 Feb;14(4):200-3. [Accessed 02 Jan. 2026]. Available from:

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Disclaimer

Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: Ajanta Pharma Limited
Address: Ajanta House, Charkop, Kandivli West, Mumbai 400 067, India

Vendor Details

Country of origin: India

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Why we need a prescription?

Macrogol Sachet

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General Information

Contains

Marketer

Storage

Product introduction

Uses of Macrogol Oral Solution

Benefits of Macrogol Oral Solution

Side effects of Macrogol Oral Solution

How to use Macrogol Oral Solution

How Macrogol Oral Solution works

All substitutes for Macrogol Sachet

Movicol Liquid One Dose Orange

Quick tips

Safety advice

Alcohol

Pregnancy

Breast feeding

Driving

Kidney

Liver

Frequently asked questions

What is Macrogol Sachet used for?

How should I take Macrogol Sachet for colonoscopy preparation?

Can I take my regular medicines with this colon preparation Macrogol Sachet?

Who should not take Macrogol Sachet?

Can I eat or drink before taking Macrogol Sachet for colonoscopy?

How long does Macrogol Sachet take to start working?

Can Macrogol Sachet cause dehydration or electrolyte imbalance?

What should I do if I vomit after taking the Macrogol Sachet?

Fact Box

Habit Forming

Therapeutic Class

References

User feedback

Patients taking Macrogol Sachet

Want to know more

Have issue with the content

Disclaimer

Marketer details

Vendor Details

Lab tests offered by us

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