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Lupizep Plus 25 mg/0.5 mg Tablet

Prescription Required
Manufacturer
Storage
Store at room temperature (10-30°C)

Overview

Introduction

Lupizep Plus 25 mg/0.5 mg Tablet is a prescription medicine used to treat depression. It is a combination medicine which works by increasing the level of chemical messengers in the brain that improves mood. It also calms the brain by decreasing the abnormal and excessive activity of the nerve cells.

Lupizep Plus 25 mg/0.5 mg Tablet can be taken with or without food. It is advised to take it at a fixed time each day to maintain a consistent level of medicine in the blood. Take this medicine in the dose and duration advised by your doctor as it has habit-forming potential. Try to never skip any doses, but if you miss a dose of this medicine, take it as soon as you remember. Finish the full course of treatment even if you feel better. It is important not to stop taking this medicine suddenly as it may result in withdrawal symptoms.

Some common side effects of this medicine include nausea, vomiting, confusion, memory impairment, low sexual desire, confusion, and delayed ejaculation. It may cause dizziness and sleepiness. So, do not drive or do anything that requires mental focus until you know how this medicine affects you.  It is important to inform your doctor if you develop any unusual changes in mood or depression as this medicine may cause suicidal thoughts.

Take caution while taking medicine if you are suffering from liver disease. Your doctor should also know about all other medicines you are taking as many of these may make this medicine less effective or change the way it works. Inform your doctor if you are pregnant, planning pregnancy or breastfeeding.

Uses of Lupizep Plus Tablet

Side effects of Lupizep Plus Tablet

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Lupizep Plus

  • Nausea
  • Vomiting
  • Diarrhea
  • Confusion
  • Memory impairment
  • Uncoordinated body movements
  • Drowsiness
  • Tiredness
  • Anorgasmia (decreased orgasm)
  • Low sexual desire
  • Delayed ejaculation

How to cope with side effects?

The occurrence of side effects varies from person to person. The following are a few ways of dealing with some of the common side effects. However, consult your doctor if these persist.

  • Coping with Nausea
    You can help yourself by eating small, frequent meals rather than large ones and drinking plenty of fluids. Eat slowly. Avoid fatty, fried, spicy and very sweet foods. Eat cold or slightly warm food if the smell of cooked or cooking food makes you feel sick. Get plenty of fresh air. You could also try chewing ginger or drinking ginger tea. Eat bananas to replace potassium in your blood which can drop if you are sick (vomit). Use oral rehydration salts to replace vitamins and minerals lost through being sick. There are some medicines that can help you stop from feeling sick. Speak to your doctor if your condition does not improve.
  • Coping with Vomiting
    You can help yourself by eating small, frequent meals rather than large ones and drinking plenty of fluids. Eat slowly. Avoid fatty, fried, spicy and very sweet foods. Eat cold or slightly warm food if the smell of cooked or cooking food makes you feel sick. Get plenty of fresh air. You could also try chewing ginger or drinking ginger tea. Eat bananas to replace potassium in your blood which can drop if you are sick (vomit). Use oral rehydration salts to replace vitamins and minerals lost through being sick. There are some medicines that can help you stop feeling sick. Speak to your doctor if your condition does not improve.
  • Coping with Diarrhea
    Keep up your intake of fluids and electrolytes (sugars and salts) to avoid getting dehydrated. Eat less fiber (avoid raw fruits, fruit juice and vegetables). Talk to your doctor about possible medication to manage diarrhea. Ask about reducing the dosage of your drug or other suitable treatments.
  • Coping with Confusion
    If this medicine makes you feel this way, stop what you are doing and sit or lie down until you feel better. If the feeling does not go away or troubles you, do not take any more medicine and speak to a pharmacist or your doctor.
  • Coping with Memory impairment
    There is a lot you can do to improve your memory. Keep active and take regular exercise to improve blood flow to your whole body, including your brain. Eat a healthy diet so your brain gets the nutrients it needs. Some foods containing omega-3 fatty acids (such as oily fish) may benefit brain health. Keep mentally active. It is important to socialize, so stay in contact with friends and family. Stay organised – keep a diary for things you have to do, keep things you need regularly (such as keys, purse and spectacles) in a set place and do not try to do too many things at once. Make sure you get good sleep, make it a priority. Drinking alcohol can lead to confusion and memory loss, so try to cut down or stop. Also, stop smoking because it reduces the amount of oxygen that gets to your brain. If you are worried about memory loss, talk to your doctor, especially if it affects your ability to live your daily life.
  • Coping with Drowsiness
    If the medicine is making you drowsy during the day, stop what you are doing and sit or lie down until you feel better. You can also consider taking a nap. Physical exercises such as walking may be helpful. Do not drink alcohol, as it will make you feel more tired. Avoid driving or operating heavy equipment when you are feeling drowsy. This problem usually goes away as your body gets used to the medicine. However, if it does not, ask your doctor if you can take your medicine at bedtime or whether the dose can be reduced.
  • Coping with Tiredness
    Make sure you rest and drink plenty of fluids. Eat a well-balanced diet to keep your energy levels up. Do not drink too much alcohol. Do not drive or use tools or machinery until you feel better. Other things that can help include doing some gentle exercise every day, prioritizing and pacing your activities and having a short nap if you need to. If you are still having problems after a week, speak to your doctor, as they may want to change you to a different type of medicine.
  • Coping with Delayed ejaculation
    Speak to your doctor as they may be able to change your medicine or offer other treatments that might help with the problem. Making healthy lifestyle changes and eating a healthy balanced diet can help. Lose weight if you are overweight. Exercise daily and try to reduce stress and anxiety. Avoid the use of alcohol, cigarettes or recreational drugs such as marijuana which can also affect sexual function. Counselling or psychotherapy can also be helpful.

How to use Lupizep Plus Tablet

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Lupizep Plus 25 mg/0.5 mg Tablet may be taken with or without food, but it is better to take it at a fixed time.

How Lupizep Plus Tablet works

Lupizep Plus 25 mg/0.5 mg Tablet is a combination of two medicines: Paroxetine and Clonazepam which has mood-enhancing and anxiety-lowering effects. Paroxetine is selective serotonin reuptake inhibitor (SSRI) which increases the levels of serotonin, a chemical messenger that improves mood. Clonazepam is a benzodiazepine (BZD) which increases the action of GABA, a chemical messenger that suppresses the abnormal activity of the nerve cells in the brain.

Safety Advice

Alcohol
UNSAFE
It is unsafe to consume alcohol with Lupizep Plus 25 mg/0.5 mg Tablet.
Pregnancy
UNSAFE
Lupizep Plus 25 mg/0.5 mg Tablet is highly unsafe to use during pregnancy. Seek your doctor's advice as studies on pregnant women and animals have shown significant harmful effects to the developing baby.
Breastfeeding
CONSULT YOUR DOCTOR
Lupizep Plus 25 mg/0.5 mg Tablet is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.
Driving
UNSAFE
Lupizep Plus 25 mg/0.5 mg Tablet may cause side effects which could affect your ability to drive.
Kidney
SAFE IF PRESCRIBED
Lupizep Plus 25 mg/0.5 mg Tablet is probably safe to use in patients with kidney disease. Limited data available suggests that dose adjustment of Lupizep Plus 25 mg/0.5 mg Tablet may not be needed in these patients. Please consult your doctor.
Use of Lupizep Plus 25 mg/0.5 mg Tablet can cause excessive sleepiness in patients with end stage kidney disease.
Liver
CAUTION
Lupizep Plus 25 mg/0.5 mg Tablet should be used with caution in patients with liver disease. Dose adjustment of Lupizep Plus 25 mg/0.5 mg Tablet may be needed. Please consult your doctor.

Alternate Brands

For informational purposes only. Consult a doctor before taking any medicines.
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Fact Box

Habit Forming
Yes

Patient Concerns

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I am suffering depression from 20 year I am consuming depsonil 25 mg and Trinicalm plus 10 mg but now days there is not good sleep is there any side effect on my health due to consuming medicine for long period
Dr. Jyoti Kapoor Madan
Psychiatry
All long term medicines need regular monitoring to identify if there are any side effects. The effects and sude effects have to be rationally balanced. Don't continue medicines without follow up with the prescribing psychiatrist for proper monitoring. If you are having trouble sleeping, you may need a change of medication.
I am using climaxing p.if I change Citico plus 500 mg/400 mg
Dr. Vikas Sharma
Neurology
u can if it is same salt
arrow
Do you have any questions related to Lupizep Plus 25 mg/0.5 mg Tablet ?

FAQs

Q. Are there any important warnings associated with the use of Lupizep Plus?

Lupizep Plus may increase the suicidal thoughts or actions in some patients, in the first few months of the treatment. Patients having mood or behavioral disorder have a high risk of suicidal thoughts and actions. You should pay close attention and report your doctor of any changes in behavior or mood. Make sure that you visit the doctor for the follow-up appointments as scheduled.

Q. Can I stop taking Lupizep Plus when my symptoms are relieved?

No, you should continue taking Lupizep Plus even if you feel well. If you stop Lupizep Plus suddenly, serious withdrawal symptoms may occur. Your doctor will probably decrease your dose gradually.

Q. How to manage weight gain associated with the use of Lupizep Plus?

There are reports that suggest that the use of Lupizep Plus can cause weight gain. If you keep good eating habits and exercise regularly, you might not gain any weight. It is important to remember that it is easier to stop weight gain than losing increased weight.

Q. Can the use of Lupizep Plus cause sleepiness?

Yes, Lupizep Plus can make you feel sleepy. Avoid driving, operating machinery, working at heights or participating in potentially dangerous activities till you know how this medicine affects you.

Q. Can the use of Lupizep Plus affect my sex life?

The use of Lupizep Plus can affect the sexual life of both men and women. Different sexual problems can occur due to Lupizep Plus like decreased sexual desire, erectile dysfunction (inability to develop or maintain erection during the sexual activity) and inability to reach orgasm. It can also cause a decrease in satisfaction and cause discomfort during intercourse. If you experience these problems, discuss with your doctor.

Q. Can I drink alcohol while taking Lupizep Plus?

No, do not drink alcohol while taking Lupizep Plus. Drinking alcohol can increase the severity of drowsiness or sleepiness caused by Lupizep Plus.

Q. How long does Lupizep Plus take to work?

Everybody responds differently to treatment. In general, it can take several weeks to feel the full benefits of Lupizep Plus, although some people may start to feel better sooner. When taking Lupizep Plus, it is important to give it time to work.

Q. What are the instructions for the storage and disposal of Lupizep Plus?

Keep this medicine in the packet or the container it came in, tightly closed. Store it according to the instructions mentioned on the pack or label. Dispose of the unused medicine. Make sure it is not consumed by pets, children and other people.

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1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover all possible side effects, drug interactions or warnings or alerts. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

References

  1. Paroxetine. Miami, Florida:Noven Therapeutics; 2003 [revised 06-2013]. [Accessed 23 Apr. 2019] (online) Available from:External Link
  2. Clonazepam. Boucherville, Québec: Sandoz Canada Inc.; 2018. [Accessed 23 Apr. 2019] (online) Available from:External Link
  3. Paroxetine. South Ruislip, Middlesex: Aurobindo Pharma - Milpharm Ltd.; 2008 [revised 25 Nov. 2018]. [Accessed 23 Apr. 2019] (online) Available from:External Link
  4. Clonazepam. Boucherville, Québec: Sandoz Canada Inc.; 2018. [Accessed 23 Apr. 2019] (online) Available from:External Link

Manufacturer/Marketer Address

Lupin Ltd, 3rd floor Kalpataru Inspire, Off. W E Highway, Santacruz (East), Mumbai 400 055. India
NOT FOR SALE
We do not facilitate sale of this product at present

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