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Lofen MR Tablet is a combination medicine which helps in relieving muscle pain. It relieves muscle stiffness or spasm and improves the movement of muscles. It works by blocking the release of certain chemical messengers that cause pain, inflammation, and fever.

Written By Dr. Sakshi Jain, MS, BDS,
Reviewed By Dr. Rajeev Sharma, MBA, MBBS,
Last updated on 23 Jan 2026 | 11:54 PM (IST)
₹31.8 MRP ₹35.1610% off 
Gurgaon
 
 
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General Information

Contains

Diclofenac (50mg)+ Paracetamol (500mg)+ Chlorzoxazone (250mg)+ Magnesium Trisilicate (100mg)

Marketer

Medix Laboratories

Storage

Store below 30°C
The content is shown in English
Lofen MR Tablet image
Lofen MR Tablet image

Product introduction

Lofen MR Tablet may be prescribed alone or in combination with another medicine. You should take it regularly as advised by your doctor. It should be taken with food. This will prevent you from getting an upset stomach. Do not take more or use it for longer than recommended by your doctor.

Using this medicine may cause few common side effects such as nausea, vomiting, heartburn, stomach pain, and diarrhea. If any of these side effects do not resolve with time or get worse, you should let your doctor know. Your doctor may help you with ways to reduce or prevent them.

The medicine may not be suitable for everybody. Before taking it, let your doctor know if you have any problems with your heart, kidneys, and liver. Let your doctor also know about all the other medicines you are taking to make sure it is safe for you. Pregnant and breastfeeding mothers should consult their doctors before using this medicine.

Uses of Lofen MR Tablet

  • Treatment of Muscle pain

Benefits of Lofen MR Tablet

Treatment of Muscle pain
Lofen MR Tablet treats muscle pain by relaxing stiff muscles. It also reduces swelling in the muscles. Altogether, it helps in easy movement and reduces discomfort. Once you see some improvement, you can start doing therapy exercises (such as walking or breathing exercises) that will help you get your strength back more quickly. Magnesium Trisilicate, an inorganic salt present in Lofen MR Tablet prevents acidity that may occur due to the painkillers.

Side effects of Lofen MR Tablet

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Lofen MR
  • Nausea
  • Vomiting
  • Stomach pain
  • Loss of appetite
  • Sleepiness

How to use Lofen MR Tablet

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Lofen MR Tablet should be taken with or after food.

How Lofen MR Tablet works

Lofen MR Tablet is a combination of four medicines: Diclofenac, Paracetamol, Chlorzoxazone and Magnesium Trisilicate which relieve pain and relax the muscles. Diclofenac is a non-steroidal antiinflammatory drug (NSAID) and Paracetamol is an antipyretic (fever reducer). They work by blocking the release of certain chemical messengers in the brain that cause pain and fever. Chlorzoxazone is a muscle relaxant. It works on the centers in the brain and spinal cord to relieve muscle stiffness or spasm and to improve pain and movement of muscles. Magnesium Trisilicate is an inorganic salt that neutralizes the excess acid in the stomach.

Quick tips

  • You have been prescribed Lofen MR Tablet to get relief from pain and stiffness in the muscles.
  • Along with taking Lofen MR Tablet, your doctor might advise you to undergo physiotherapy to get relief from pain.
  • You might experience nausea, ask your doctor to prescribe you an antiemetic (anti-sickness medicine) if it troubles you.
  • Inform your doctor if you have a history of seizures, heart disease, or stroke.
  • Liver problems may occur while you are using this medicine. Stop using this medicine and check with your doctor right away if you are having more than one of these symptoms: abdominal pain, clay-colored stools, dark urine, fever, itching, loss of appetite, tiredness, or yellow eyes or skin.

Safety advice

Alcohol

Alcohol

CAUTION
Alcohol should be used with caution while taking Lofen MR Tablet.
Pregnancy

Pregnancy

UNSAFE
Lofen MR Tablet is highly unsafe during pregnancy. It can cause serious harm to the unborn baby, including birth defects and pregnancy loss. Do not use this medicine if you are pregnant or planning to become pregnant.
Breast feeding

Breast feeding

CONSULT YOUR DOCTOR
Lofen MR Tablet may be unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby. It should be used only if the expected benefit outweighs the potential risk. Please consult your doctor.
Driving

Driving

CONSULT YOUR DOCTOR
It is not known whether Lofen MR Tablet alters the ability to drive. Do not drive if you experience any symptoms that affect your ability to concentrate and react. Please consult your doctor.
Kidney

Kidney

CAUTION
Lofen MR Tablet should be used with caution in patients with severe kidney disease. Dose adjustment may be needed.
Liver

Liver

UNSAFE
Lofen MR Tablet is unsafe to use in patients with liver disease and should be avoided.
However, the use of Lofen MR Tablet is not recommended in patients with severe liver disease and active liver disease.

Fact Box

Habit Forming

No

Therapeutic Class

PAIN ANALGESICS

References

  1. Schreijenberg M, Luijsterburg PA, Van Trier YD, et al. Efficacy of paracetamol, diclofenac and advice for acute low back pain in general practice: design of a randomized controlled trial (PACE Plus). BMC Musculoskelet Disord. 2017 Feb 1;18(1):56. [Accessed 23 Jan. 2026]. Available from:
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User feedback

Others
100%
Average
100%
Sleepiness
33%
Nausea
33%
Stomach pain
33%
With or without food
50%
With food
50%
Average
67%
Expensive
33%
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Disclaimer

Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: Medix Laboratories
Address: 17, 1st Floor, Palika Bazar Complex, G. T. Road Ghaziabad, Uttar Pradesh

Vendor Details

Country of origin: India

Lab tests offered by us

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