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Composition for KEPHAZON TZ


food interaction for KEPHAZON TZ

alcohol interaction for KEPHAZON TZ

pregnancy interaction for KEPHAZON TZ

lactation interaction for KEPHAZON TZ

There is no data available. Please consult doctor before consuming the drug.
Kephazon tz 1000mg/125mg injection may cause symptoms such as flushing, increased heartbeat, nausea, thirst, chest pain and low blood pressure with alcohol (Disulfiram reactions).
Kephazon tz 1000mg/125mg injection is probably safe to use during pregnancy.
Either animal studies have shown no adverse effect on the fetus, but there is no human studies or animal studies have shown an adverse effect that was not confirmed in human studies. Please consult your doctor.
Unknown. Human and animal studies are not available. Please consult your doctor.




Cefoperazone is used to treat bacterial infection of the respiratory tract, the abdomen and abdominal wall (peritonitis), the urinary tract, the female genital tract (endometritis, pelvic inflammatory disease), the blood (septicemia), and the skin and soft tissues. 

How it works

Cefoperazone belongs to group of medicines called third-generation cephalosporin antibiotics. It kills the bacteria by interrupting the bacterial cell wall (outer coating of bacteria) formation. As a result, the bacterial cell wall is weakened and ruptures, thereby killing the bacteria. 

Common side effects

Nausea, Increased creatine level in blood, Increased urea nitrogen level in blood, Liver enzyme increased, Allergic reaction, Decreased haemoglobin level in blood, Diarrhoea, Inflammation of vein, Drug fever, Decreased white blood cell count, Decreased white blood cell count (eosinophils), Vomiting


Tazobactam is an antibiotic used in  combination with another antibiotic called piperacillin to treat many infections caused by bacteria, such as urinary tract infections, bone and joint infections, severe vaginal infections, stomach infections, skin infections, and pneumonia. It is also used to treat complicated intra-abdominal infections including inflammation of the membrane which lines the inside of the abdomen and the entire internal organs It is also used to treat decrease in white blood cells (neutropenia) with fever due to bacterial infection. 

How it works

Tazobactam belongs to group of medicines called beta lactamase Inhibitor  It works by preventing destruction of beta-lactam antibiotics from chemicals released from bacteria and extends their spectrum of activity.

Common side effects

Liver enzyme increased, Bruise, Bleeding, Constipation, Diarrhoea, Altered taste, Shortness of breath, Flatulence, Headache, Insomnia, Itching, Skin rash, Stomach upset, Vomiting


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Expert advice for KEPHAZON TZ

Cefoperazone is usually given by a doctor or a nurse as an injection directly into the vein or muscle. Tell your doctor if you are taking cefoperazone and undergoing any blood or urine test, as it may affect the result. Do not start or continue the cefoperazone and consult your doctor:
  • If you have history of allergy due to cefoperazone or any other cephalosporin or penicillin antibiotics.
  • If you experience severe and persistent diarrhea after taking antibiotics.
  • If you are already taking any other antibiotic like aminoglycosides or other cephalosporins as it may cause kidney toxicity.

Frequently asked questions for KEPHAZON TZ


Q. What is cefoperazone sulbactam?
Combination of cefoperazone and sulbactam (beta lactamase inhibitor) are used for the treatment of intra-abdominal infections.
Q. Is cefoperazone nephrotoxic?
No, cefoperazona is not a nephrotoxic drug when given alone, but when given along with aminoglycosides (gentamicin, tobramycin) or other cephalosporins antibiotics, it may increase nephrotoxicity. Please consult your doctor before taking the drug.
Q. Is cefoperazone safe?
Cefoperazone is safe if used at prescribed doses for the prescribed duration as advised by your doctor.


Q. Is tazobactam a sulfa (sulfonamide) drug?
Sulbactam does not contain sulfa. It is a beta lactamase Inhibitor.
Q. What is tazobactam sodium?
Tazobactam is a beta-lactamase inhibitor used as the sodium salt to increase the antibacterial activity of piperacillin.
Q. What is tazact 4.5?
Tazact 4.5 is the brand name for combination of tazobactam and piperacillin.
Q. What organisms does tazobactam/piperacillin cover?
Tazobactam in combination with piperacillin is mainly effective against anaerobes and enterococcus, listeria, staphylococcus, citrobacter, haemophilus, moraxella and proteus species but methicillin-resistant staphylococci are resistant to tazobactam/piperacillin.
Q. Is tazobactam safe?
Tazobactam is safe if used at prescribed doses for the prescribed duration as advised by your doctor.


Content on this page was last updated on 15 September, 2016, by Dr. Varun Gupta (MD Pharmacology)