
INSTREL GEL
Written By Dr. Sakshi Jain, MS, BDS
Reviewed By Dr. Sachin Gupta, MD Pharmacology, MBBS
Last updated on 09 Mar 2026 | 10:46 AM (IST)
INSTREL GEL is a pain relieving medicine. It is used in the treatment of pain and inflammation. It helps relieve pain and swelling in postoperative wounds and other inflammatory diseases.
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General Information
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Product introduction
INSTREL GEL is for external use only. It may be prescribed alone or in combination with other medicines. You should use it as advised by your doctor. You should not use it on skin which is broken, bruised, or blistered. If it gets into your eyes, nose, or mouth, vagina, immediately rinse with plenty of water.
The medicine is well-tolerated with little or no side effects. However, if you experience any side effects which you feel is caused by the medicine, let your doctor know. Your doctor may be able to suggest ways of preventing or reducing the symptoms.
Although medicines used on the skin are not normally affected by other medicines you should let your doctor know if you are taking any other medicine to be safe. Ask your doctor for advice if you are pregnant or breastfeeding.
The medicine is well-tolerated with little or no side effects. However, if you experience any side effects which you feel is caused by the medicine, let your doctor know. Your doctor may be able to suggest ways of preventing or reducing the symptoms.
Although medicines used on the skin are not normally affected by other medicines you should let your doctor know if you are taking any other medicine to be safe. Ask your doctor for advice if you are pregnant or breastfeeding.
Uses of Instrel Gel
Benefits of Instrel Gel
Pain relief
INSTREL GEL gives relief in inflammatory conditions that affect muscles and joints such as rheumatoid arthritis and osteoarthritis. It also helps reduce pain and swelling after surgery. It blocks chemical messengers in the brain that are responsible for pain sensation. Along with painkillers, this medicine also contains an active ingredient called Serratiopeptidase, which is an enzyme that promotes the overall healing process and speeds up recovery. Apply INSTREL GEL 2-3 times in a day or as prescribed by the doctor. Once you see some improvement, you can start doing therapy exercises (such as walking or breathing exercises) that will help you get your strength back more quickly.
INSTREL GEL gives relief in inflammatory conditions that affect muscles and joints such as rheumatoid arthritis and osteoarthritis. It also helps reduce pain and swelling after surgery. It blocks chemical messengers in the brain that are responsible for pain sensation. Along with painkillers, this medicine also contains an active ingredient called Serratiopeptidase, which is an enzyme that promotes the overall healing process and speeds up recovery. Apply INSTREL GEL 2-3 times in a day or as prescribed by the doctor. Once you see some improvement, you can start doing therapy exercises (such as walking or breathing exercises) that will help you get your strength back more quickly.
Side effects of Instrel Gel
Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Instrel
- No common side effects seen
How to use Instrel Gel
This medicine is for external use only. Use it in the dose and duration as advised by your doctor. Check the label for directions before use. Clean and dry the affected area and apply the gel. Wash your hands after applying, unless hands are the affected area.
How Instrel Gel works
INSTREL GEL is a combination of three medicines: Tramadol, Paracetamol and Serratiopeptidase. Tramadol is an opoid analgesic (pain reliever) which works by blocking transmission of pain signals to the brain to lower pain perception. Paracetamol is an analgesic and anti-pyretic (fever reducer) which works by blocking the release of certain chemical messengers that cause pain and fever. Serratiopeptidase is an enzyme which works by breaking down abnormal proteins at the site of inflammation, and promotes healing.
Quick tips
- INSTREL GEL is prescribed to get relief from pain.
- Apply 2-3 times daily or as prescribed by the doctor.
- Do not apply this medicine to large areas of skin or near sensitive areas such as private parts or on broken or injured skin.
- Avoid using INSTREL GEL right after bathing or shaving. Using this medication on freshly shaved skin areas can cause severe skin irritation.
- Consult your doctor if you get excessive skin irritation or other unwanted effects.
Safety advice

Alcohol
No interaction found/established

Pregnancy
CONSULT YOUR DOCTOR
INSTREL GEL is not recommended during pregnancy as there is positive evidence of fetal risk based on animal studies. However, it may still be prescribed by a doctor in situations where the benefits outweigh the risks.

Breast feeding
CONSULT YOUR DOCTOR
Information regarding the use of INSTREL GEL during breastfeeding is not available. Please consult your doctor.

Driving
No interaction found/established

Kidney
No interaction found/established

Liver
No interaction found/established
Fact Box
Habit Forming
No
Therapeutic Class
PAIN ANALGESICS
References
- Schumacher MA, Basbaum AI, Way WL. Opioid Analgesics & Antagonists. In: Katzung BG, Masters SB, Trevor AJ (Editors). Basic and Clinical Pharmacology. 11th ed. New Delhi, India: Tata McGraw Hill Education Private Limited; 2009. pp. 531-552.
- Grosser T, Smyth EM, FitzGerald GA. Pharmacotherapy of Inflammation, Fever, Pain, and Gout. In: Brunton LL, Hilal-Dandan R, Knollmann BC (Editors). Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. 13th ed. New York, NY: McGraw-Hill Education; 2018. pp. 685-709.
- Yaksh T, Wallace M. Opioids, Analgesia, and Pain Management. In: Brunton LL, Hilal-Dandan R, Knollmann BC (Editors). Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. 13th ed. New York, NY: McGraw-Hill Education; 2018. pp. 355-387.
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Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.
Marketer details
Name: Dr Reddy's Laboratories Ltd
Address: Dr. Reddy's Laboratories Ltd., Village Malpur, P.O.Bhud, Baddi, Dist. Solan, H.P.
Address: Dr. Reddy's Laboratories Ltd., Village Malpur, P.O.Bhud, Baddi, Dist. Solan, H.P.
Vendor Details
Country of origin: India
Lab tests offered by us
- CBC (Complete Blood Count)
- FBS (Fasting Blood Sugar)
- Thyroid Profile Total (T3, T4 & TSH)
- HbA1c (Glycosylated Hemoglobin)
- PPBS (Postprandial Blood Sugar)
- Lipid Profile
- Vitamin D (25-Hydroxy)
- Urine R/M (Urine Routine & Microscopy)
- Coronavirus Covid -19 test- RT PCR
- LFT (Liver Function Test)
- KFT (Kidney Function Test)
- TSH (Thyroid Stimulating Hormone) Ultrasensitive
- ESR (Erythrocyte Sedimentation Rate)
- Uric Acid, Serum
- Vitamin B12
- CRP (C-Reactive Protein), Quantitative
- Urine C/S (Urine Culture and Sensitivity)
- Serum Electrolytes
- Serum Calcium
- Serum Creatinine
- Diabetes Screening (HbA1C & Fasting Sugar)
- KFT with Electrolytes (Kidney Function Test with Electrolytes)
- Cholesterol - Total
- Hb (Hemoglobin)
- Complete Hemogram (CBC & ESR)
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