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Grenil Tablet

Written By Dr. Swati Mishra, BDS
Reviewed By Dr. Mekhala Chandra, MD, MBBS
Last updated on 25 Nov 2025 | 03:07 PM (IST)
Grenil Tablet is a prescription medicine used in the treatment of migraine. It prevents pain signals to reach the brain to reduce pain. It also blocks certain substances in the brain that trigger nausea or vomiting during migraine headaches.
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General Information

Contains

Domperidone (20mg)+ Paracetamol (500mg)

Marketer

Karnataka Antibiotics & Pharmaceuticals Ltd

Storage

Store below 25°C
The content is shown in English
Grenil Tablet image
Grenil Tablet image
Grenil Tablet image
Grenil Tablet image

Product introduction

Grenil Tablet is taken without food in a dose and duration as advised by the doctor. The dose you are given will depend on your condition and how you respond to the medicine. You should keep taking this medicine for as long as your doctor recommends. If you stop treatment too early your symptoms may come back and your condition may worsen. Let your healthcare team know about all other medications you are taking as some may affect, or be affected by this medicine.

The most common side effect is dryness in mouth. This is temporary and usually resolve with time. Contact your doctor straight away if you are at all concerned about these side effects. Migraine attacks can be managed by identifying migraine-causing triggers which may be red wine, caffeine withdrawal, stress, and skipped meals, etc. You can identify personal triggers by maintaining a diary of what you are doing, what you are eating, and any stressful activity happened before migraine attack.

Before taking this medicine, you should tell your doctor if you are pregnant, planning pregnancy or breastfeeding. You should tell your doctor if you have any kidney or liver diseases so that your doctor can prescribe a suitable dose for you.

Uses of Grenil Tablet

Benefits of Grenil Tablet

Treatment of Migraine
Grenil Tablet is a combination of medicines that helps prevent migraine by changing the way that your nerves receive pain signals. It also blocks the action of chemicals in the body that can make you feel or be sick. This treats as well as prevents nausea or vomiting effectively. By preventing and reducing the frequency of headaches, it can help you carry out your daily activities and have a better quality of life.

Side effects of Grenil Tablet

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Grenil
  • Dryness in mouth

How to use Grenil Tablet

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Grenil Tablet is to be taken on an empty stomach.

How Grenil Tablet works

Grenil Tablet is a combination of two medicines: Domperidone and Paracetamol. Domperidone is a prokinetic which works on the region in the brain that controls vomiting. It also increases the movement of the stomach and intestines, allowing food to move more easily through the stomach. This prevents nausea and vomiting caused due to migraine. Paracetamol is an analgesic (pain reliever) and an anti-pyretic (fever reducer) which blocks the release of certain chemical messengers that cause pain and fever associated with migraine.

All substitutes for Grenil Tablet

For information purposes only. Consult a doctor before taking any medicine.

Diike 20mg/500mg Tablet

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₹3.14/tablet
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<h3 class=bodySemiBold>Diike 20mg/500mg Tablet</h3>

Pacidom P 20mg/500mg Tablet

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₹5.06/tablet
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<h3 class=bodySemiBold>Pacidom P 20mg/500mg Tablet</h3>

Quick tips

  • Grenil Tablet helps to ease the pain you feel during a migraine headache as well as helps to stop you from feeling sick.
  • Dry mouth may occur as a side effect. Frequent mouth rinses, good oral hygiene, increased water intake and sugarless candy may help.
  • Inform your doctor if you are taking any pain relief medicine.
  • Grenil Tablet can only decrease the number and severity of attacks but may not completely stop them.
  • Some tips that may help avoid a migraine attack:
    1. Have your meals at the same time every day.
    2. Avoid bright lights and extreme temperatures.
    3. Avoid loud music and noisy places.
    4. Avoid chocolates,  cheese, processed food, alcohol, and smoking.
    5. Get sufficient sleep and avoid stress.
  • Grenil Tablet helps to ease the pain you feel during a migraine headache as well as helps to stop you from feeling sick.
  • Dry mouth may occur as a side effect. Frequent mouth rinses, good oral hygiene, increased water intake and sugarless candy may help.
  • Inform your doctor if you are taking any pain relief medicine.
  • Grenil Tablet can only decrease the number and severity of attacks but may not completely stop them.
  • Some tips that may help avoid a migraine attack:
    1. Have your meals at the same time every day.
    2. Avoid bright lights and extreme temperatures.
    3. Avoid loud music and noisy places.
    4. Avoid chocolates,  cheese, processed food, alcohol, and smoking.
    5. Get sufficient sleep and avoid stress.

Safety advice

Alcohol

Alcohol

UNSAFE
It is unsafe to consume alcohol with Grenil Tablet
Pregnancy

Pregnancy

CONSULT YOUR DOCTOR
The safety of Grenil Tablet during pregnancy has not been established. There are no adequate and well-controlled studies in pregnant women, and animal data on reproductive toxicity are insufficient. Your doctor will weigh the benefits and any potential risks before prescribing.
Breast feeding

Breast feeding

SAFE IF PRESCRIBED
Available human data suggest that the drug does not pass into breast milk in clinically significant amounts and is unlikely to harm the infant.
Driving

Driving

UNSAFE
Grenil Tablet may decrease alertness, affect your vision, or make you feel sleepy and dizzy. Do not drive if these symptoms occur.
Kidney

Kidney

CAUTION
Grenil Tablet should be used with caution in patients with kidney disease. Dose adjustment may be needed.
Liver

Liver

CAUTION
Grenil Tablet should be used with caution in patients with liver disease. Dose adjustment may be needed.
However, the use of Grenil Tablet is not recommended in patients with severe liver disease and active liver disease.

Frequently asked questions

Grenil Tablet is a combination of two medicines: Domperidone and Paracetamol/Acetaminophen. Domperidone helps to control vomiting. It also increases the movement of the stomach and intestines, allowing food to move more easily through the stomach. This prevents nausea and vomiting caused due to migraine. Paracetamol/Acetaminophen is an analgesic (pain reliever) and an anti-pyretic (fever reducer) which blocks the release of certain chemical messengers that cause pain and fever associated with migraine.
No, taking a higher than the recommended dose of Grenil Tablet can increase the risks of side effects and liver damage. If you are experiencing increased severity of symptoms that are not relieved by the recommended doses, please consult your doctor for re-evaluation.
No, there is no report of any patient getting addicted to Grenil Tablet.
Yes, Grenil Tablet can cause harm to the liver especially in the doses above the recommended level. Also, avoid drinking alcohol while taking this medicine, as it may further increase your risk of liver damage. Use of this medicine should preferably be avoided in patients with the underlying liver disease.
Keep this medicine in the container or the pack it came in, tightly closed. Store it according to the instructions mentioned on the pack or label. Dispose of the unused medicine. Make sure it is not consumed by pets, children and other people.

Fact Box

Habit Forming

No

Therapeutic Class

NEURO CNS

References

  1. Domperidone maleate. South Ruislip, Middlesex: Aurobindo Pharma - Milpharm Ltd.; 2003 [revised 14 Nov. 2017]. [Accessed 15 Apr. 2019] (online) Available from:
  2. ScienceDirect. Domperidone. [Accessed 15 Apr. 2019] (online) Available from:
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User feedback

Once A Day
80%
Thrice A Day
20%
Migraine
41%
Headache
38%
Others
12%
Fever
7%
Pain during menstruation
2%
Average
40%
Excellent
33%
Poor
27%
Dryness in mouth
52%
No Side Effect
35%
Allergic reaction
9%
Boils
4%
With food
70%
With or without food
21%
Empty stomach
10%
Not Expensive
35%
Average
34%
Expensive
31%
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Disclaimer

Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: Karnataka Antibiotics & Pharmaceuticals Ltd
Address: Dr. Rajkumar Road Rajajinagar, 1st Stage Bangalore- 560 010 India

Vendor Details

Country of origin: India
A licensed vendor partner from your nearest location will deliver Grenil Tablet. Once the pharmacy accepts your order, the details of the pharmacy will be shared with you. Acceptance of your order is based on the validity of your doctor's â„ž and the availability of this medicine.

In case of any issues, contact us

Email ID: [email protected]
Phone Number: 0124-4166666
Address: 5th Floor Tower - B of the Presidency Building, 46/4 Mehrauli Gurgaon Road, Sector 14, Gurugram, Haryana-122001, India

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